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33

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T83679	Parasin I (catfish) TFA
	Parasin I是来自鲶鱼(P. asotus)组蛋白H2A N端区域的一种抗微生物肽片段，参与宿主防御。它通过在受伤P. asotus的皮肤黏膜中的cathepsin D从组蛋白H2A形成。Parasin I对多种革兰氏阳性和阴性细菌以及真菌具有活性（MICs分别为1-2, 1-4, 和1-2 µg/ml）。
T83666	Kisspeptin-10 (zebrafish) TFA Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10
	Kisspeptin-10是一种在斑马鱼的大脑、卵巢和睾丸中表达的神经肽，参与性腺发育和类固醇表达。在10 ng/ml的浓度下使用时，能提高孤立的斑马鱼卵巢滤泡中编码黄体生成素(luteinizing hormone, Lh)受体，以及孕酮受体a (Progestin receptor a, Pra)和Prb的mRNA水平。在0.1和1 µg/g的剂量下给予时，Kisspeptin-10能在雌性金鱼中增加黄体生成素的血清水平，但在雄性金鱼中则不会。
T20812	Azamethiphos 甲基吡啶磷,唑啶磷	AChE	Neuroscience
	Azamethiphos 是有机磷杀虫剂和神经毒性物质，能够抑制乙酰胆碱酯酶的活性。
T0305	Erythrosine B Erythrosine I,Erythrosin extra bluish,Erythrosin B,赤藓红B	Others	Others
	Erythrosine B (Erythrosine I) 是一种已被用于开发动物模型的新型光敏剂，在食品和纺织工业的人造染料中具有广泛的应用。
T0578	Erythrosin B Iodeosin,Tetraiodofluorescein,藻红B	Others	Others
	Erythrosin B (Iodeosin) 是一种四碘荧光素，在某些食物（樱桃、鱼）中用作红色色素，用作某些细胞类型的染色剂，以及用作牙菌斑的披露物。其分子结构与甲状腺素相似。
T7556	Fadrozole hydrochloride CGS 16949A,盐酸法倔唑	Aromatase	Endocrinology/Hormones
	Fadrozole hydrochloride (CGS 16949A) 是一种选择性的、有效，和非甾体类的芳香化酶抑制剂(IC50:6.4 nM)。
T21483	Tricaine methanesulfonate 3-氨基苯甲酸乙酯甲基磺酸盐,MS-222	Others	Others
	Tricaine methanesulfonate (MS-222) 常用于固定鱼的标记和运输，并能抑制入侵过程中的感觉系统。
T37514	Hydroxy Dimetridazole	Drug Metabolite	Metabolism
	Hydroxy Dimetridazole 是Dimetridazol 的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物，可用于对抗原生动物感染。
T34563	Scaritoxin
	Scaritoxin is a potent toxic substance isolated from poisonous fish.
T31931	Gizzerosine
	Gizzerosine exists in the overheated fish meal that causes gizzard erosion in chicks.
T13866	Retinyl glucoside Retinyl β-D-glucoside	Others	Others
	Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, and are found in fish and mammals.
T35620	Ethoxyquin Dimer
	Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2
T30173	Aspartyllysine Asp-lys
	Aspartyllysine is a hydrophilic dipeptide widely distributed in nature. It is present in wheat, fish, and other nutrients. It is excreted by the kidney-specific high-affinity H+/peptide cotransport system.
T39546	Fluorescein tyramide
	Fluorescein tyramide is a widely utilized green fluorescent reagent (λ abs : 494 nm; λ em : 517 nm), primarily employed for tyramide signal amplification (TSA) in low-abundance IHC, ICC, in situ hybridization (FISH), and flow cytometry (FCM) applications.
T76593	(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)
	'(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)' 为一种GnRH类似物，主要用于诱导养殖鱼类排卵和/或产卵。
T37990	15-keto Prostaglandin F1α 15-keto Prostaglandin F1α
	15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.
T80443	ω-Conotoxin MVIID SNX-238	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ω-Conotoxin MVIID (SNX-238) 是芋螺肽，能抑制ω-Conotoxin-GVIA敏感的高阈值Ca2+电流于鱼类视网膜神经节细胞。
T37532	Docosahexaenoyl Glycine
	The ω-3 polyunsaturated fatty acids (PUFAs) found in fish oils provide cardiovascular benefits. Docosahexaenoic acid (DHA), a C22:6 PUFA, is the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. It can be synthesized from other dietary ω-3 PUFAs or taken as a nutritional supplement. Docosahexaenoyl glycine consists of DHA with glycine attached at its carboxy terminus.
T37242	(±)5(6)-DiHETE
	Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils. EPA is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite produced from EPA following epoxidation of the α-5 double bond. The biological activity of (±)5(6)-DiHETE has not been documented.
T35681	MeIQx
	MeIQx (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3
T74905	ODN 2007
	ODN 2007是一种B类CpG ODN(寡脱氧核苷酸)，兼具Toll样受体(TLR)配体功能。作为免疫调节剂和疫苗佐剂，它能够增强哺乳动物、鱼类及人类的免疫反应。其序列为5'-TCGTCGTTGTCGTTTTGTCGTT-3'。
T71302	Norfluoxetine-d5 HCl
	Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewa...
T37634	17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
	Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T37632	TFM
	TFM is a piscicide.1It is toxic to sea lamprey (P. marinus) with LC50values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. TFM (50 μM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively.2Formula...
T80378	Tilapia piscidin 3
	Tilapia piscidin 3 是具抗菌谱广的肽类化合物，有效对抗多种革兰氏阳性菌与阴性菌，其对 V. vulnificus 204、V. alginolyticus、S. agalactiae 819、E. faecalis BCRC 10066、S. agalactiae BCRC 10787 的最小抑菌浓度 (MIC) 分别为 2.44、2.44、9.78、19.55、0.61 μg/mL。同時，Tilapia piscidin 3 对鱼红细胞显示出溶血性。
T35437	(-)-Viriditoxin
	(-)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml). (-)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MI...
T38208	Heneicosapentaenoic Acid
	Heneicosapentaenoic Acid (HPA) is a 21:5 ω-3 fatty acid present in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the δ6 position. HPA can be used to study the significance of the position of the double bonds in ω-3 fatty acids. It incorporates into phospholipids and into triacylglycerol in vivo with the same efficiency as EPA and...
T38127	pNPS-DHA
	pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) in mice. 1.Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al.Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivoJ. Med. Chem.62(21)9576-9592(2019)
T83705	BING TFA Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria
	BING是一种来源于日本稻田鱼(O. laptipes)的抗菌肽，由液泡蛋白质分选相关蛋白13D样(Vps13D)衍生而来。对包括耐甲氧西林的金黄色葡萄球菌(MRSA; MICs = 4-64 µg/ml)在内的各种革兰氏阴性和革兰氏阳性细菌都有活性。与氨苄西林、阿莫西林和新霉素共同使用时，对抗铜绿假单胞菌(P. aeruginosa)表现出协同效应，并能抑制大肠杆菌(E. coli)对卡那霉素和氨苄西林的抗药性发展。在体内，BING提高了被鳗弧菌(E. tarda)感染的O. laptipes的生存率。
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T35790	Palmitic acid-1,2,3,4-13C4 Palmitic Acid-13C (C1, C2, C3, and C4 labeled)
	Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...

化合物

Parasin I (catfish) TFA

Cat.No: T83679

Kisspeptin-10 (zebrafish) TFA

Cat.No: T83666

Synonym: Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10

Cat.No: T20812

Synonym: 甲基吡啶磷,唑啶磷

Target: AChE

Cat.No: T0305

Synonym: Erythrosine I,Erythrosin extra bluish,Erythrosin B,赤藓红B

Target: Others

Cat.No: T0578

Synonym: Iodeosin,Tetraiodofluorescein,藻红B

Target: Others

Fadrozole hydrochloride

Cat.No: T7556

Synonym: CGS 16949A,盐酸法倔唑

Target: Aromatase

Tricaine methanesulfonate

Cat.No: T21483

Synonym: 3-氨基苯甲酸乙酯甲基磺酸盐,MS-222

Target: Others

Hydroxy Dimetridazole

Cat.No: T37514

Target: Drug Metabolite

Cat.No: T34563

Cat.No: T31931

Retinyl glucoside

Cat.No: T13866

Synonym: Retinyl β-D-glucoside

Target: Others

Ethoxyquin Dimer

Cat.No: T35620

Cat.No: T30173

Synonym: Asp-lys

Fluorescein tyramide

Cat.No: T39546

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)

Cat.No: T76593

15-keto Prostaglandin F1α

Cat.No: T37990

Synonym: 15-keto Prostaglandin F1α

ω-Conotoxin MVIID

Cat.No: T80443

Synonym: SNX-238

Target: Calcium Channel

Docosahexaenoyl Glycine

Cat.No: T37532

(±)5(6)-DiHETE

Cat.No: T37242

Cat.No: T35681

Cat.No: T74905

Norfluoxetine-d5 HCl

Cat.No: T71302

17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Cat.No: T37634

Cat.No: T37632

Tilapia piscidin 3

Cat.No: T80378

(-)-Viriditoxin

Cat.No: T35437

Heneicosapentaenoic Acid

Cat.No: T38208

Cat.No: T38127

Cat.No: T83705

Synonym: Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria

Cat.No: T35881

Palmitic acid-1-13C

Cat.No: T35789

Palmitic acid-1,2,3,4-13C4

Cat.No: T35790

Synonym: Palmitic Acid-13C (C1, C2, C3, and C4 labeled)

Palmitic acid-13C

Cat.No: T35791

Cat. No.	Product Name	Target	Signaling Pathways
T5613	Squalane 角鲨烷,Dodecahydrosqualene,Perhydrosqualene	Others	Others
	Squalane (Perhydrosqualene) 是某些鱼油 (尤其是鲨鱼肝油) 和某些植物油中存在的脂质。它具有抗癌，抗氧化作用，可用作皮肤保湿和润肤剂。
T19284	Dimethylmalonic acid 2,2-Dimethylmalonic acid	Endogenous Metabolite	Metabolism
	Dimethylmalonic acid（2,2-Dimethylmalonic acid）是人血清中的短链二羧酸，可用于预防或延缓鱼肌动球蛋白在冷冻缓冲溶液（pH 7）中的变性。
T20091	Stearamide Stearic acid amide,NSC 66462,NSC66462,NSC-66462
	Stearamide(Stearic acid amide)是一种初级脂肪酸酰胺，具有细胞毒性和鱼类毒性,可用于增加纳米颗粒的性能。
T22291	Chitin Chitin (From shrimp and crab shells)	Others	Others
	Chitin 是一种大型的结构多糖，存在于真菌的细胞壁、昆虫的外骨骼以及鱼类和无脊椎动物的某些坚硬结构中。
T65269	L-Aspartic acid potasium salt Aspartic acid potasium salt,Potassium L-aspartate	Others	Others
	L-aspartic acid potasium salt（VX-548）是一种广泛存在于动植物体内的氨基酸。L-aspartic acid potasium salt驱动氮氧化物的产生，从而促进吞噬作用，有助于提高鱼类的成活率。L-aspartic acid potasium salt 可对抗生素产生刺激，刺激作用可能与参与天冬氨酸-4-半醛生物合成的前体有关。
TJO2742	DL-Methionine 蛋氨酸,methionine,DL-蛋氨酸,Acimetion,Racemethionine	Parasite	Microbiology/Virology
	DL-Methionine (Acimetion) 存在于肉类、鱼类和奶制品中，是可用于动物的天然饲料，还可杀死马铃薯上的金线虫。它是一种含有硫的必需氨基酸，具有氧化应激防御作用。
T4775	Arachidic acid eicosanoic acid,Icosanoic Acid,花生酸	Others; Endogenous Metabolite	Metabolism; Others
	Arachidic acid (Icosanoic Acid) 是一种存在于所有哺乳动物细胞中的长链脂肪酸，通常酯化为膜磷脂，是人体组织中丰富的多不饱和脂肪酸之一。
T4827	Trimethylammonium chloride 三甲胺盐酸盐,Trimethylamine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Trimethylammonium chloride (Trimethylamine hydrochloride) 是动植物分解的产物。它是造成鱼腥味的主要物质，通常与脏鱼、细菌性阴道感染和口臭有关。它也与服用大剂量胆碱有关。三甲胺尿是一种遗传性疾病，身体无法从食物中代谢三甲胺。食用富含胆碱的食物后，患者的汗液、尿液和呼吸中会出现特有的鱼腥味。三甲胺尿症是一种常染色体隐性遗传病，涉及三甲胺氧化酶缺乏症。三甲氨基尿症在罗德岛红鸡中也有发现，这种鸡产的蛋有腥味。尿液中的 Trimethylammonium chloride 是食用豆类的生物标志物。
T2A2498	L-Lysine Aminutrin,Lysine Acid,lysine,L-赖氨酸,赖氨酸	Virus Protease; Endogenous Metabolite; Antifection	Metabolism; Microbiology/Virology
	L-Lysine (Aminutrin) 是一种人类必需氨基酸，能增加钙吸收，减少糖尿病相关疾病和改善肠道健康，可用于疱疹的研究。
T3138	Astaxanthin β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin,虾青素	Reactive Oxygen Species; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB
	Astaxanthin (trans-Astaxanthin) 是可从雨生红球藻等多种海洋生物中提取得到的红色类胡萝卜素，是过氧化物酶体增殖物活化受体γ 的调节剂，具有抗增殖、神经保护作用和抗炎活性。它是一种抗氧化剂，有用于癌症和心血管疾病的研究潜力，作为颜色添加剂用于动物食品中。
TN6872	Trypsin	Protease-activated Receptor	GPCR/G Protein
	Trypsin 是一种可从鱼类分离出的丝氨酸蛋白酶，可水解赖氨酸或精氨酸羧基侧蛋白质。Trypsin 具有抗炎活性，可通过 PDCoV 的 S 糖蛋白与 pAPN 的相互作用诱导 PDCoV 感染的细胞膜融合，可激活 PAR2 和 PAR4，促进细胞增殖和分化。Trypsin 可用于促进伤口愈合和研究神经源性炎症。
T30451	Biliatresone
	Biliatresone is a very rare natural isoflavone-related 1, 2-diaryl-2-allenone found in Dysphania Glomulifera and D. littoralis. It has been found to cause extrahepatic biliary atresia in zebra fish models.

天然产物

Cat.No: T5613

Synonym: 角鲨烷,Dodecahydrosqualene,Perhydrosqualene

Target: Others

Dimethylmalonic acid

Cat.No: T19284

Synonym: 2,2-Dimethylmalonic acid

Target: Endogenous Metabolite

Cat.No: T20091

Synonym: Stearic acid amide,NSC 66462,NSC66462,NSC-66462

Cat.No: T22291

Synonym: Chitin (From shrimp and crab shells)

Target: Others

L-Aspartic acid potasium salt

Cat.No: T65269

Synonym: Aspartic acid potasium salt,Potassium L-aspartate

Target: Others

Cat.No: TJO2742

Synonym: 蛋氨酸,methionine,DL-蛋氨酸,Acimetion,Racemethionine

Target: Parasite

Cat.No: T4775

Synonym: eicosanoic acid,Icosanoic Acid,花生酸

Target: Others, Endogenous Metabolite

Trimethylammonium chloride

Cat.No: T4827

Synonym: 三甲胺盐酸盐,Trimethylamine hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T2A2498

Synonym: Aminutrin,Lysine Acid,lysine,L-赖氨酸,赖氨酸

Target: Virus Protease, Endogenous Metabolite, Antifection

Cat.No: T3138

Synonym: β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin,虾青素

Target: Reactive Oxygen Species, PPAR

Cat.No: TN6872

Target: Protease-activated Receptor

Cat.No: T30451

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