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29

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8581	Flecainide hydrochloride	Others	Others
	Flecainide hydrochloride 是一种用于预防和治疗异常快速心率的药物。这包括室性和室上性心动过速。
T21652	RN-1 dihydrochloride	Histone Demethylase; MAO	Chromatin/Epigenetic; Metabolism; Neuroscience
	RN-1 dihydrochloride 是血脑屏障通透性的、不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 选择性抑制剂，IC50为 70 nM，对 LSD1 的选择性高于 MAO-A 和 MAO-B，IC50分别为 0.51 μM 和 2.785 μM。
T4996	Atosiban 阿托西班,RWJ22164,RW22164	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Atosiban (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。
T2445	FG-2216 YM-311,FG2216,FG 2216	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	FG-2216 (YM-311) 是一种有效的、口服具有活力的HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂，IC50=3.9 nM。它在体内能够诱导促红细胞生成素生成和胎儿血红蛋白的表达。
T5148	Atosiban acetate RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Atosiban acetate (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。
T19583	TN1	Others	Others
	TN1 是一种有效的胎儿型血红蛋白 (HbF) 诱导剂。
T40380	17α-Hydroxyprogesterone acetate	Others	Others
	17α-Hydroxyprogesterone acetate 具有孕激素活性和抗炎活性。
T19739	Simazine Tafazine,Aquazine,Radocon,Herbex,西玛津	Others	Others
	Simazine (Tafazine) 是三嗪类除草剂，普遍用于农业、盆栽植物和树木的生产。它具有植物毒性，但对土壤微生物和藻类毒性较低。
T4100	AS8351 NSC51355,AS-8351,AS 8351	Histone Demethylase	Chromatin/Epigenetic
	AS8351 (NSC51355) 是一种组蛋白去甲基化酶抑制剂，可以诱导人胎儿肺成纤维细胞重编程为功能性心肌细胞。
T60898	HbF inducer-1
	HbF inducer-1 是一种胎儿血红蛋白诱导剂，具有口服生物活性。
T34639	Sigetin
	Sigetin affects the transport of calcium and magnesium in uterine smooth muscle and can be used in fetal development.
TP2339	Goralatide
	Goralatide, isolated from fetal calf bone marrow, exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells.
T36920	16α-hydroxy Dehydroepiandrosterone
	16α-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone .116α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosteronevia16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol .2 1.Miller, K.K.M., Cai, J., Ripp, S.L., et al.Stereo- and regioselectivity account for the diversity of dehydro...
T70000	Ebopiprant HCl
	Ebopiprant, also known as OBE-022, is an Oral and Selective Prostaglandin F 2α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor. OBE022 exhibits potent tocolytic effects on human tissues ex vivo and animal models in vivo without causing the adverse fetal side effects seen with indomethacin.
T80480	αA-Conotoxin OIVA αA-OIVA
	αA-Conotoxin OIVA（αA-OIVA）作为一种多肽，源自芋螺毒素，它是一种选择性nAChR拮抗剂，针对哺乳动物胎儿肌肉nAChR展现出56 nM的IC50值，具备麻痹肌肉的能力。
T35774	HC Toxin
	HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.
T80486	αA-Conotoxin PIVA
	αA-Conotoxin PIVA是选择性针对小鼠肌肉nAChR的抑制剂，对成年和胎儿型小鼠肌肉nAChR的IC50分别为2.3 nM及22 nM。该化合物可应用于神经系统疾病研究领域。
T38045	Cholesterol β-D-Glucoside
	Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity...
T37409	DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 (trifluoroacetate salt)
	DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants...
T37004	Estradiol 3-sulfate 17β-Glucuronide (potassium salt)
	Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol , and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma. Sulfated estrogens, including estradiol 3-sulfate, can be converted back to the parent compound by sulfatases. Estradiol 3-sulfate 17β-glucuronide is a metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase. Glucuronidation of estrogens enhances their utilization by anion transporters, most com...
T36385	Ansatrienin A
	Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl...
T80167	αC-Conotoxin PrXA αC-PrXA
	αC-Conotoxin PrXA为麻痹肽类神经毒素，亦是竞争性nAChR拮抗剂，对α1β1εδ（成人型）和α1β1γδ（胎儿型）nAChR的IC50值分别为1.8 nM和3.0 nM。该化合物通过与α-bungarotoxin竞争nAChR的α/δ及α/γ亚基界面，展现出对神经肌肉型nAChR的高度特异性。
T37210	5-hydroxy Indomethacin
	5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes. 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytesPediatr. Res.15(11)1406-1410(1981)
T36350	Cho-Arg (trifluoroacetate salt)
	Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul...
T36359	Dios-Arg (trifluoroacetate salt)
	Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...
T34030	Phosphatidyl choline (from egg yolk) Azolectin,PC. Phosphatidyl choline,L-α-Lecithin
	Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from w
T38100	Betamethasone 21-phosphate (sodium salt hydrate)
	Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top...
T36418	O-Desmethyl-N-deschlorobenzoyl Indomethacin
	O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ...

化合物

Flecainide hydrochloride

Cat.No: T8581

Target: Others

RN-1 dihydrochloride

Cat.No: T21652

Target: Histone Demethylase, MAO

Cat.No: T4996

Synonym: 阿托西班,RWJ22164,RW22164

Target: Oxytocin Receptor, Vasopressin Receptor

Cat.No: T2445

Synonym: YM-311,FG2216,FG 2216

Target: HIF/HIF Prolyl-Hydroxylase

Atosiban acetate

Cat.No: T5148

Synonym: RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班

Target: Oxytocin Receptor, Vasopressin Receptor

Cat.No: T19583

Target: Others

17α-Hydroxyprogesterone acetate

Cat.No: T40380

Target: Others

Cat.No: T19739

Synonym: Tafazine,Aquazine,Radocon,Herbex,西玛津

Target: Others

Cat.No: T4100

Synonym: NSC51355,AS-8351,AS 8351

Target: Histone Demethylase

Cat.No: T60898

Cat.No: T34639

Cat.No: TP2339

16α-hydroxy Dehydroepiandrosterone

Cat.No: T36920

Cat.No: T70000

αA-Conotoxin OIVA

Cat.No: T80480

Synonym: αA-OIVA

Cat.No: T35774

αA-Conotoxin PIVA

Cat.No: T80486

Cholesterol β-D-Glucoside

Cat.No: T38045

DPC-AJ1951 (trifluoroacetate salt)

Cat.No: T37409

Synonym: DPC-AJ1951 (trifluoroacetate salt)

Estradiol 3-sulfate 17β-Glucuronide (potassium salt)

Cat.No: T37004

Cat.No: T36385

αC-Conotoxin PrXA

Cat.No: T80167

Synonym: αC-PrXA

5-hydroxy Indomethacin

Cat.No: T37210

Cho-Arg (trifluoroacetate salt)

Cat.No: T36350

Cat.No: T36650

Dios-Arg (trifluoroacetate salt)

Cat.No: T36359

Phosphatidyl choline (from egg yolk)

Cat.No: T34030

Synonym: Azolectin,PC. Phosphatidyl choline,L-α-Lecithin

Betamethasone 21-phosphate (sodium salt hydrate)

Cat.No: T38100

O-Desmethyl-N-deschlorobenzoyl Indomethacin

Cat.No: T36418

Cat. No.	Product Name	Target	Signaling Pathways
T41033	Fetuin, Fetal Bovine Serum
	Fetuin, Fetal Bovine Serum is a glycoprotein weighing 64 kDa that is secreted by the liver and obtained from fetal bovine serum. It acts as an inhibitor of trypsin activity and facilitates cellular attachment, growth, and differentiation.
T19189	Allocholic acid	Others	Others
	Allocholic acid 是一种胆汁酸，在脊椎动物中发现，在肝脏再生和致癌过程中会重新出现，也是成熟嗅觉系统的特定性刺激物。
T41335	cis-Vaccenic acid cis-11-Octadecenoic acid,Asclepic acid,(Z)-octadec-11-enoic acid	Antiviral	Immunology/Inflammation
	cis-Vaccenic acid (Asclepic acid) 是来自 Rhodopseudomonas capsulate 的抗病毒提取物，是 Rhodopseudomonas capsulate 的主要活性成分，cis-Vaccenic acid 可用作潜在的胎儿血红蛋白诱导剂。
T6S1880	Benzoylaconine 苯甲酰乌头原碱,Pikraconitin,Isaconitine,Benzoylaconitine	Others	Others
	Benzoylaconine (Isaconitine) 是一种中药附子生物碱。
T15248	Estetrol Donesta	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estetrol(Donesta) 是可口服且具有选择性核雌激素受体 (estrogen receptor) 调节剂,是一种在怀孕期间由人类胎儿肝脏合成的天然雌激素。Estetrol 对子宫内膜或中枢神经系统有作用，但对乳房有拮抗作用。Estetrol 在低浓度时可能有助于降低血栓形成。Estetrol 可用于缓解更年期症状。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
TN5245	Vitexolide D	Antifection	Microbiology/Virology
	Vitexolide D shows moderate antibacterial activity against a panel of 46 Gram-positive strains. It also shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line (1 < IC50s < 10 uM).

天然产物

Fetuin, Fetal Bovine Serum

Cat.No: T41033

Allocholic acid

Cat.No: T19189

Target: Others

cis-Vaccenic acid

Cat.No: T41335

Synonym: cis-11-Octadecenoic acid,Asclepic acid,(Z)-octadec-11-enoic acid

Target: Antiviral

Cat.No: T6S1880

Synonym: 苯甲酰乌头原碱,Pikraconitin,Isaconitine,Benzoylaconitine

Target: Others

Cat.No: T15248

Synonym: Donesta

Target: Estrogen Receptor/ERR, Endogenous Metabolite

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

Cat.No: TN5245

Target: Antifection

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