fetal

FG-2216 (YM-311) 是一种有效的、口服具有活力的HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂，IC50=3.9 nM。它在体内能够诱导促红细胞生成素生成和胎儿血红蛋白的表达。

Allocholic acid 是一种胆汁酸，在脊椎动物中发现，在肝脏再生和致癌过程中会重新出现，也是成熟嗅觉系统的特定性刺激物。

RN-1 dihydrochloride 是血脑屏障通透性的、不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 选择性抑制剂，IC50为 70 nM，对 LSD1 的选择性高于 MAO-A 和 MAO-B，IC50分别为 0.51 μM 和 2.785 μM。

Fetuin, Fetal Bovine Serum is a glycoprotein weighing 64 kDa that is secreted by the liver and obtained from fetal bovine serum. It acts as an inhibitor of trypsin activity and facilitates cellular attachment, growth, and differentiation.

Vasicinol (6-Hydroxypeganine) 是一种可从Adhatoda vasica （L.）， Nees 中分离出来的吡咯喹唑啉生物碱，是蔗糖酶抑制剂，抑制大鼠肠道α-葡萄糖苷酶的蔗糖水解活性，Ki值为183μM。Vasicinol 是一种 HbF 诱导剂，可用研究代谢紊乱和糖尿病。

Atosiban (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。

Atosiban acetate (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。

Flecainide hydrochloride 是一种用于预防和治疗异常快速心率的药物。这包括室性和室上性心动过速。

Simazine (Tafazine) 是三嗪类除草剂，普遍用于农业、盆栽植物和树木的生产。它具有植物毒性，但对土壤微生物和藻类毒性较低。

17α-Hydroxyprogesterone acetate 具有孕激素活性和抗炎活性。

AS8351 (NSC51355) 是一种组蛋白去甲基化酶抑制剂，可以诱导人胎儿肺成纤维细胞重编程为功能性心肌细胞。

Benzoylaconine (Isaconitine) 是一种中药附子生物碱。

Estetrol(Donesta) 是可口服且具有选择性核雌激素受体 (estrogen receptor) 调节剂,是一种在怀孕期间由人类胎儿肝脏合成的天然雌激素。Estetrol 对子宫内膜或中枢神经系统有作用，但对乳房有拮抗作用。Estetrol 在低浓度时可能有助于降低血栓形成。Estetrol 可用于缓解更年期症状。

TN1 是一种有效的胎儿型血红蛋白 (HbF) 诱导剂。

UNC0638 hydrate 作为一种化合物，主要通过选择性抑制G9a和GLP组蛋白甲基转移酶达到其生物活性，其半抑制浓度(IC50)分别为15 nM和19 nM。在体外实验中，此化合物有效抑制TNBC（三阴性乳腺癌）细胞的侵袭与迁移。同时，作为EHMT1 2的抑制剂，它能在人红细胞祖细胞的培养中诱导胎儿血红蛋白(HbF)的表达。此外，UNC0638 hydrate 对FMDV（口蹄疫病毒）和VSV（水疱性口炎病毒）均显示出抗病毒活性，展现了其在多种表观遗传和非表观遗传靶标上的高效力和选择性。

ASP8731 作为一种选择性的BACH1抑制剂，能有效抑制炎症和血管闭塞，同时在镰状细胞病治疗中诱导胎儿血红蛋白的生成。

Diallyl phthalate (NSC 7667) 是一种广泛使用的不饱和聚酯交联剂，在一定浓度下可引起胎儿中毒。

2-Ethylhexyl diphenyl phosphate 是一种有机磷阻燃剂 (OPFRs) 及PPARG激动剂 (EC20：2.04 µM)，能抑制ERRγ的转录活性 (IC50：1.3 µM)，并可上调3β-HSD1、人绒毛膜促性腺激素 (hCG) 和progesterone的分泌。该化合物适用于女性生殖和胎儿发育的研究。

DS79932728 是一种口服有效的G9a和GLP抑制剂，IC50值分别为12.6 nM和75.7 nM。它通过诱导γ-珠蛋白 (γ-globin) 的产生来提高胎儿血红蛋白 (HbF) 水平。在食蟹猴模型中，DS79932728 增加了F-网织红细胞 (F-rets) 的比例，并表现出了良好的口服吸收特性。

Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from w

Sigetin affects the transport of calcium and magnesium in uterine smooth muscle and can be used in fetal development.

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It is cytotoxic to H1299 cells (IC50 = 88.5 μg/ml).

Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It has been used, coupled to 1,2-dioleoyl-sn-glycero-3-PE , to bind siRNA and plasmid DNA to form cationic lipid nanoparticles for intracellular transport. Dios-Arg is cytotoxic to H1299 and HeLa cells (IC50s = 83.5 and 74.1 μg/ml, respectively).