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Cat. No. | Product Name | Target | Signaling Pathways |
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T67628 |
DiSC3(5)
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T25045 |
Aleurodiscal
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Aleurodiscal is used as an antifungal sesterterpenoid. | |||
T126016 |
Discodermide
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Discodermide 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126016。 | |||
T25342 | Discobahamin A | ||
Discobahamin A is a bioactive peptide isolated from a new species of the Bahamian deep water marine sponge Discodermia. It is a growth of Candida albicans inhibitor. | |||
T25343 | Discobahamin B | ||
Discobahamin B is a bioactive peptide isolated from a new species of the Bahamian deep water marine sponge Discodermia. It is a growth of Candida albicans inhibitor. | |||
T30077 |
Anisperimus
LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195 |
Caspase | Apoptosis; Proteases/Proteasome |
Anisperimus (LF 15-0195) 是一种免疫抑制剂,通过促进 DISC 水平的 caspase-8 和 caspase-10 激活来增强激活诱导的 T 细胞死亡,通过促进表达 Foxp3 的调节性 CD4 T 细胞的发育来预防中枢神经系统自身免疫。 | |||
T36048 |
Linearmycin A
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Linearmycin A is a polyene antibiotic that has been found inStreptomyces.1It is active against the bacteriaS. aureusandE. coli(MICs = 3.1 and 1.6 μg/disc, respectively), the fungiS. cerevisiaeandC. albicans(MICs = 0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungusA. nigerin disc assays (MIC = 0.2 μg/disc). Linearmycin A induces lysis and degradation ofB. subtilisas a component ofStreptomycesMg1 extract.2 1.Sakuda, S., Guce-Bigol, U., Itoh, M., et al.Novel linear polyene antibiot... | |||
T35485 |
6-Prenylindole
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6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg/ml).2 |1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity o... | |||
T38274 |
Papyracillic Acid
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Papyracillic acid is a fungal metabolite and a derivative of penicillic acid originally isolated fromL. papyraceumand has antibiotic, antifungal, and phytotoxic activities.1,2It is active against the bacteriaX. campestrisandB. subtilisand the fungusC. tropicalisin a disc assay when used at a concentration of 5 μg/disc.2Papyracillic acid (1 mg/ml) induces necrotic lesion formation in a panel of 10 plants. 1.Shan, R., Anke, H., Stadler, M., et al.Papyracillic acid, a new penicillic acid analogue f... | |||
T37674 | Aspyrone | ||
Aspyrone is a polyketide fungal metabolite that has been found inAspergillusand has diverse biological activities.1,2It is active against a panel of 13 fungi when used at a concentration of 20 μg/ml and a panel of 21 bacteria in a disc assay when used at a concentration of 100 μg per disc.1Aspyrone (10-1,000 mg/L) is nematocidal againstP. penetrans.2 1.Torres, M., Balcells, M., Sala, N., et al.Bactericidal and fungicidal activity of Aspergillus ochraceus metabolites and some derivativesPestic. S... | |||
T37730 |
Saccharocarcin A
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Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/ml. | |||
T36875 | Sartorypyrone D | ||
Sartorypyrone D is a fungal metabolite that has been found inN. fischeri.1It inhibits NADH fumarate reductase (NFRD; IC50= 1.7 μM inA. suummitochondria) and NADH oxidase (IC50= 3 μM in bovine heart mitochondria). Sartorypyrone is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andM. smegmatisin disc assays. 1.Kaifuchi, S., Mori, M., Nonaka, K., et al.Sartorypyrone D: A new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897J. Antibiot. (Tokyo)68(6)403-4... | |||
T36477 |
Urdamycin A
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Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilisand strains ofArthrobacterandStreptomyces, but not the fungusS. cerevisiae, in a disc assay when used at a concentration of 1 mg/ml.2Urdamycin A is cytotoxic to L1210 and HT-29, but not A549, cancer cells (IC50s = 7.5, 5, and >10 μg/ml, respectively).1 | |||
T35692 |
Myxochelin A
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Myxochelin A is a microbial metabolite that has been found inA. disciformisand has diverse biological activities.1It is active against Gram-positive bacteria, includingB. cereus,S. aureus, andM. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50value of 1.9 μM for the recombinant human enzyme.2It is cytotoxic to 26-L5 colon cancer cells when used at a concentratio... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3849 |
Kinsenoside
金线莲苷,(+)-Kinsenoside |
Apoptosis; Nrf2 | Apoptosis; Immunology/Inflammation |
Kinsenoside ((+)-Kinsenoside) 是从金盏花属植物中分离得到的主要活性成分,以 Nrf2 依赖的方式保护髓核细胞在氧化应激下的生存能力,防止细胞凋亡、衰老和线粒体功能障碍。它显示出显着的抗肝毒性和抗炎活性。 | |||
T79973 |
Dehydrodiscretamine chloride
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Dehydrodiscretamine chloride作为AChE和BChE的双重抑制剂,展现了其抑制效力,其中对AChE的IC50为17.8 μM,对BChE的IC50为118.8 μM。此外,该化合物具备抗氧化活性,并可被应用于阿尔茨海默病相关研究。 | |||
TN3396 |
Alpinumisoflavone acetate
4'-O-Acetylalpinumisoflavone |
Others | Others |
Alpinumisoflavone acetate (4'-O-Acetylalpinumisoflavone) 是一种新的alpinumisoflavone 衍生物。Alpinumisoflavone 在0.63 ug/disc 时强烈抑制生殖管生长。 | |||
TN1213 |
2-(Hydroxymethyl)anthraquinone
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Anti-infection | Microbiology/Virology |
2-(Hydroxymethyl)anthraquinone 是光可清除保护基团,在结构上可以阻碍性信息素释放。 | |||
TN1833 |
Karacoline
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NF-κB | NF-κB |
Karacoline 是发现于植物Aconitum kusnezoffii 中的一种二萜生物碱,通过 NF-κB 信号通路,抑制椎间盘退变中细胞外基质的降解。 | |||
T36473 |
trans-Nerolidol
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trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re... | |||
T64812 |
Collagenase Type I
Collagenase I,Collagenase Type I (From microorganisms) |
Others | Others |
Collagenase Type I 是一种蛋白水解酶,能分解胶原蛋白中的肽键(胶原蛋白是结缔组织的主要结构蛋白)。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质,从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组,潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。 | |||
TN3783 |
Deacetylsalannin
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Others | Others |
Deacetylsalannin shows antifeedant activity against Reticulitermes speratus Kolbe (95% protective concentration or PC95 = 1373.1 ug/disc). | |||
T36044 |
17-hydroxy Venturicidin A
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17-hydroxy Venturicidin A is a macrolide fungal metabolite originally isolated from Streptomyces. It has antibiotic activity against M. luteus, B. subtilis, and S. aureus and antifungal activity against V. dahlia, Fusarium, and C. tropicalis in a disc assay. | |||
T38104 |
Deoxyfusapyrone
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Deoxyfusapyrone is an α-pyrone fungal metabolite originally isolated from F. semitectum and has antifungal activity. It is active against C. neoformans, A. fumigatus, A. niger, and A. flavus human mycoses (MICs = 1.56-6.25 μg/ml). Deoxyfusapyrone is also active against a variety of filamentous fungi, but not yeast or the bacterium B. megaterium, in a disc assay. | |||
T36815 | Chevalone C | ||
Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells. | |||
TN1864 |
Licoisoflavone B
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Antifection | Microbiology/Virology |
Licoisoflavone B is an inhibitor of germ tube growth in the arbuscular mycorrhizal (AM) fungus Gigaspora margarita, it can strongly inhibit germ tube growth at 0.63 ug/disc. | |||
TN2219 |
Sophoraisoflavone A
鲁冰花,砂生槐异黄酮 A |
MRP; Antifection | Immunology/Inflammation; Microbiology/Virology |
Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tube growth at 1.25 ug/disc. Sophoraisoflavone A shows inhibitory effects on copper-induced prot | |||
TN5119 | Taxoquinone | Tyrosinase; Antifection | Microbiology/Virology; Proteases/Proteasome |
Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens. It (100 ug/disc) displays potential anticandidal effect against Candia albica | |||
T36992 |
Monocerin
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Monocerin is a fungal metabolite that has been found inF. larvarumand has diverse biological activities.1,2,3It is active against the bacteriaE. coliandB. megaterium, the phytopathogenic fungusM. violaceum, and the algaC. fuscain an agar diffusion assay when used at a concentration of 50 μg/disc.1Monocerin (17.5 μg/ml) induces mortality in adultC. erythrocephala.2It reduces root elongation in pre-germinatedS. halepenseseeds when used at a concentration of 33 ppm.3 1.Zhang, W., Krohn, K., Draeger... | |||
T36489 |
Malformin A
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Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati... | |||
T35752 |
Xanthoquinodin A1
Xanthoquinodin A1 |
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Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg/ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cance... |