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T0001
|
Iron(II) fumarate
Ferrous fumarate,Iron Fumarate,富马酸铁 (II),富马酸亚铁
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Others |
Others |
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Iron(II) fumarate (Ferrous fumarate) 是一种口服活性膳食补充剂，是一种富马酸的铁 (II) 盐，可用于研究缺铁性贫血。 |
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T0490
|
Chlorpropamide
Diabinese,氯磺丙脲
|
ATPase;
ABC |
Membrane transporter/Ion channel |
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Chlorpropamide (Diabinese) 是口服降糖剂，可用于研究非胰岛素依赖型糖尿病。 |
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T1593
|
Ezetimibe
依泽替米贝,SCH 58235
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Others;
Nrf2;
NPC1L1;
Autophagy |
Autophagy;
Immunology/Inflammation;
Membrane transporter/Ion channel;
Others |
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Ezetimibe (SCH 58235) 是一种膳食胆固醇吸收抑制剂。它是一种NPC1L1抑制剂，是有效的Nrf2激活剂。 |
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T7593
|
Levomefolate calcium
左旋甲状腺素钙,L-5-甲基四氢叶酸钙
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Antifolate |
Cell Cycle/Checkpoint |
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Levomefolate calcium 是一种人工形式的叶酸。它是叶酸的一种辅酶形式，是膳食补充剂中生物利用度更高的替代品。 |
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T26551
|
Acetyl-L-carnitine
RO 447190,L-Acetylcarnitine,LAC,L-O-Acetylcarnitine,ALCAR,Acetyl L carnitine
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Endogenous Metabolite |
Metabolism |
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Acetyl-L-carnitine(RO 447190) 是一种可透过血脑屏障的氨基酸左旋肉碱，常作为膳食补充剂，对神经炎症有益。Acetyl-L-carnitine 具有神经保护作用，可用以研究像阿尔茨海默病类的神经疾病。 |
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T6344
|
Sevelamer hydrochloride
Sevelamer HCl
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FXR;
Autophagy |
Autophagy;
Metabolism |
|
Sevelamer hydrochloride (Sevelamer HCl) 是一种磷酸盐结合药物，用于通过与膳食磷酸盐结合并阻止其吸收来治疗高磷血症。 |
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T20062
|
Thiamine disulfide
二硫化硫胺,TDS,Daiomin,Algoneurina
|
HIV Protease;
Endogenous Metabolite |
Metabolism;
Microbiology/Virology;
Proteases/Proteasome |
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Thiamine disulfide (Algoneurina) 是一种存在于食物中的维生素，可作为膳食补充剂和药物生产。 它还充当许多中枢代谢酶的辅助因子。 |
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T6267
|
Lomitapide
AEGR-733,洛美他派,BMS-201038
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CETP |
Metabolism |
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Lomitapide (AEGR-733) 是一种高效的微粒体甘油三酯转移蛋白(MTP)抑制剂，体内试验的IC50值为8 nM。 |
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T13730
|
Hydroxocobalamin acetate
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Others |
Others |
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Hydroxocobalamin acetate 是可注射的天然维生素 B12，其不良反应特征良好，可用于研究维生素 B12 缺乏症 (包括恶性贫血) 。 |
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T71704
|
Navamepent
RX-10045
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Others |
Others |
|
Navamepent (RX-10045) 是 resolvin E1 (一种膳食-3多不饱和脂肪酸代谢物)的类似物，具有强大的抗炎活性，可减少角膜炎症、上皮损伤，加速角膜组织修复。Navamepent 可抑制角膜上皮细胞释放几种关键促炎介质。Navamepent 对干眼和杯状细胞损失非常有效，可加速泪液的产生。 |
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T36126
|
TMP-153
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Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals. TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals. At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduc... |
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T26273
|
Thioquinapiperifil
KF-31327,KF 31327,KF-31327 free base,KF31327
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|
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Thioquinapiperifil is a type of phosphodiesterase-5 (PDE-5) inhibitor found in dietary supplements. |
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T19528
|
Propionylcarnitine
Propionyl carnitine
|
Others |
Others |
|
Propionylcarnitine (Propionyl carnitine) 是一种被广泛使用的膳食补充剂，有青光眼和难道破裂有关。 |
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T29689
|
AFB1-N7-guanine
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|
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|
In epidemiological studies, Aflatoxin B1-N7-guanine serum albumin adducts have been established as biomarkers of dietary aflatoxin exposure. |
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T37383
|
1,2,3-Trilinoelaidoyl-rac-glycerol
|
|
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1,2,3-Trilinoelaidoyl-rac-glycerol is a triacylglycerol that contains linoelaidic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trilinoelaidoyl-rac-glycerol (0.6-6.3% w/w) lowers serum levels of thromboxane B2 , prostaglandin F2 (PGF2), and PGE in rats.1
|1. Bruckner, G., Goswami, S., and Kinsella, J.E. Dietary trilinoelaidate: Effects on organ fatty acid composition, prostanoid biosynthesis and platelet function in rats. J. Nutr. 114(1), 58-67 (1984). |
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T37120
|
1,2,3-Triundecanoyl Glycerol
|
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1,2,3-Triundecanoyl glycerol is a triacylglycerol that contains undecanoic acid at thesn-1,sn-2, andsn-3 positions. Dietary administration of a 7:3 (w/w) mixture of 1,2,3-triundecanoyl glycerol and corn oil prevents fasting-induced decreases in plasma glucose, alanine, and insulin levels, as well as the ratio of insulin to glucagon, in rats compared with dietary administration of corn oil alone.1
1.Pi-Sunyer, F.X., Conway, J.M., Lavau, M., et al.Glucagon, insulin, and gluconeogenesis in fasted o... |
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T81472
|
Phytochelatin 6 TFA
PC 6 TFA
|
|
|
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Phytochelatin 6 TFA为植物合成的金属结合化合物，具有降低如镉等膳食有毒金属的生物可利用性的潜能。 |
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T20016
|
Diuron
HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron
|
|
|
|
Diuron is a Phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (25 nM/ml) decreases total respiration in roots of wheat by 50% and ground respiration by 100%. Diuron (2,500 ppm, dietary) increases the inc |
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T25496
|
Hexaglutamate folate
Pteglu6
|
|
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Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube |
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T36300
|
Uridine-5’-monophosphate (sodium salt hydrate)
|
|
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Uridine-5’-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5’-monophosphate (5’-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during nucleic acid biosynthesis. Formulations containing UMP have been used as dietary supplements.
1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002) |
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T37371
|
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic Acid
|
|
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4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 . While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits. |
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T81474
|
Phytochelatin 5 TFA
PC 5 TFA
|
|
|
|
Phytochelatin 5 TFA为植物合成的金属结合化合物，有潜在降低食物中有毒金属（例如镉）生物可利用性的作用。 |
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T35620
|
Ethoxyquin Dimer
|
|
|
|
Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2 |
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T81473
|
Phytochelatin 6
PC 6
|
|
|
|
Phytochelatin 6是一种植物所产生的金属结合化合物，其可能降低（如镉）等膳食有毒金属的生物利用度。 |
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T37125
|
1,3-Dipalmitoyl-2-Eicosapentaenoyl-rac-glycerol
|
|
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1,3-Dipalmitoyl-2-eicosapentaenoyl-rac-glycerol is a triacylglycerol that contains palmitic acid at the sn-1 and sn-3 positions and eicosapentaenoic acid at the sn-2 position. Dietary administration of 1,3-dipalmitoyl-2-eicosapentaenoyl-rac-glycerol decreases hepatic triacylglycerol levels in mice. |
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T36765
|
Palmitelaidic Acid methyl ester
|
|
|
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Palmitoleic acid is a common constituent of the triglycerides of human adipose tissue. Palmitoleic acid-based diets raise low-density lipoprotein cholesterol and diminish high-density lipoprotein cholesterol, even when dietary intake of cholesterol is maintained at a low level. Palmitelaidic acid is the trans isomer of the 16:1 fatty acid palmitoleic acid. While its effects on cholesterol levels are poorly studied, palmitelaidic acid can have very different effects from those of palmitoleic acid... |
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T81475
|
Phytochelatin 5
PC 5
|
|
|
|
Phytochelatin 5为植物合成的金属结合化合物，具有可能降低如镉等膳食有毒金属的生物利用度。 |
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T36230
|
C2 Ceramide (d14:1/2:0)
C2 Ceramide (d14:1/2:0)
|
|
|
|
C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid. Dietary administration of C2 ceramide (d14:1/2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fractional shortening and the number of normal cardiac contractile events in Drosophila. |
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T38259
|
Phenelfamycin E
|
|
|
|
Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens. |
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T1129
|
Benfotiamine
Benzoylthiamine monophosphate,S-Benzoylthiamine O-monophosphate,苯磷硫胺
|
Others |
Others |
|
Benfotiamine (S-Benzoylthiamine O-monophosphate) 是维生素 B1 的类似物，其吸收率和生物利用度比维生素B1高，具有直接抗氧化能力，可防止DNA 损伤。它常用作糖尿病并发症的食品补充剂。 |
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T37229
|
(±)8,9-DiHETE
|
|
|
|
(±)8,9-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid .[1] It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases. Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.[2] |
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T75328
|
Hydroxocobalamin hydrochloride
|
|
|
|
Hydroxocobalamin hydrochloride 是天然维生素B12的可注射形式，因其优良的安全性质，被用于研究维生素B12缺乏症（包括恶性贫血）相关治疗。 |
|
T37532
|
Docosahexaenoyl Glycine
|
|
|
|
The ω-3 polyunsaturated fatty acids (PUFAs) found in fish oils provide cardiovascular benefits. Docosahexaenoic acid (DHA), a C22:6 PUFA, is the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. It can be synthesized from other dietary ω-3 PUFAs or taken as a nutritional supplement. Docosahexaenoyl glycine consists of DHA with glycine attached at its carboxy terminus. |
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T35603
|
Oleic Acid-2,6-diisopropylanilide
|
|
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|
AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM. When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%. |
|
T80951
|
Trevogrumab
REGN-1033
|
|
|
|
Trevogrumab (REGN-1033) 是针对GDF8（即生长分化因子8，亦称为肌肉生长抑制素）的单克隆抗体。该化合物目前主要用于研究包括废用性萎缩、慢性疾病以及饮食及营养摄入变化等原因引起的肌肉减少症。 |
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T37754
|
Avilamycin A
|
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|
Avilamycin A is an antibiotic.1 It is active against veterinary isolates of C. perfringens (MICs = ≤0.06-0.5 mg/L) and B. hyodysenteriae (MICs = 12.5-100 μg/ml).1,2 Dietary administration of avilamycin A (15 and 30 ppm) reduces mortality in a broiler cockerel model of C. perfringens infection.3 Formulations containing avilamycin A have been used in the prevention of necrotic enteritis in livestock.
|1. Watkins, K.L., Shryock, T.R., Dearth, R.N., et al. In-vitro antimicrobial susceptibility of Cl... |
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T35881
|
Resolvin E2
|
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Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m... |
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T37119
|
1,2,3-Trioctanoyl-rac-glycerol-13C3
1,2,3-Trioctanoyl-rac-glycerol-13C3
|
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1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl-rac-glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomo... |
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T37554
|
Oleyl Anilide
|
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AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleyl analide (OA) is a weak inhibitor of acylCoA:cholesterol acyltransferase (ACAT) with an IC50 of 26 μM. OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a syndrome of eosinophilia, excessive T-cell activation, and elevated interleukin-4 (IL-4), soluble IL-2R, and IL-5. The clinical consequences are an acute pulm... |
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T35997
|
22-HDHA
|
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22-HDHA is an oxidation product of docosahexaenoic acid . In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans. |
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TP2190
|
vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus]
|
Others |
Others |
|
Vitamin D-binding protein is a multifunctional, highly expressed, polymorphic serum protein. These range from the transport of vitamin D metabolites to possible roles in the immune system and host defense. The molecular weight range, the time course of ap |
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T79919
|
S-Adenosyl-L-methionine (1,4-butanedisulfonate)
Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate)
|
Endogenous Metabolite |
Metabolism |
|
S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate 作为一种口服活性的甲基供体，它是一种膳食补充剂，对抗抑郁和缓解疼痛具有显著功效。此化合物在癌症治疗中显示了抗增殖、促进凋亡和阻止转移的潜在作用。同时，S-Adenosyl-L-methionine 1,4-butanedisulfonate 也用于肝病和骨关节炎的相关研究。 |
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T71305
|
Clofibric Acid-d4
|
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Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxal... |
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T37224
|
(±)5(6)-EpETE methyl ester
|
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(±)5(6)-EpETE methyl ester is a derivative of 5(6)-EpETE which is stable enough to ship and handle routinely.(±) 5(6)-EpETE methyl ester is a chemically less reactive derivative of 5(6)-EpETE. The active free acid can be generated from the methyl ester by careful base hydrolysis. Epoxy eicosatetraenoic acids (EpETEs) are the epoxygenase metabolites of EPA. A number of vicinal diol metabolites of EpETEs have been detected in the plasma of patients on marine oil dietary supplementation, while in s... |
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T35993
|
Epitalon (acetate)
|
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|
Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni... |
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T36384
|
DL-Tyrosine-13C9,15N
L-Tyrosine-13C9,15N
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L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3Plasma, skeletal muscle, and... |
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T35497
|
(±)7(8)-EpDPA
|
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Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids. (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting ... |
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T35790
|
Palmitic acid-1,2,3,4-13C4
Palmitic Acid-13C (C1, C2, C3, and C4 labeled)
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Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula... |
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T36947
|
Pyrithiamine (hydrobromide)
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Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner.... |
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T38187
|
6-Aminophenanthridine
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6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz . 6-Aminophenanthridine (300 μM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive w... |
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