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Search Results for " complex ii "

47

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19245	Cobalt phthalocyanine Cobaltous phthalocyanine,酞菁钴,Phthalocyanine cobalt complex,Cobalt(II) phthalocyanine	Others	Others
	Cobalt phthalocyanine (Phthalocyanine cobalt complex) 是氧化还原反应的催化剂，已经成功催化醛和酮从醛肟和酮肟中的有氧再生。
T9714	Atpenin A5	Potassium Channel	Membrane transporter/Ion channel
	Atpenin A5 是高度特异性的complex II 抑制剂，IC50为 ~10 nM。Dolastatin 10也是有效的mKATP 通道激动剂，具有心脏保活的作用。
T64624	RuPhos Pd G1 Methyl t-Butyl Ether Adduct
	Chloro(2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) 2-methoxy-2-methylpropane complex 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64624。
T1523	Teniposide 替尼泊苷,NSC 122819,替尼泊甙,VM26	Topoisomerase	DNA Damage/DNA Repair
	Teniposide (VM26) 是鬼臼毒素的半合成衍生物，具有抗肿瘤活性，通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成。
T77615	ND-011992 ND011992	Mitochondrial Metabolism; Antibacterial	Metabolism; Microbiology/Virology
	ND-011992 是一种靶向醌还原酶 (quinone reductases) 和醌氧化酶 (quinol oxidases)的喹唑啉类抑制剂，具有可逆性和选择性。ND-011992 对大肠杆菌 BL21Δcyo 呼吸复合体I (respiratory complex* I) 、 bo3 氧化酶(bo3 oxidase)、 bd-I 氧化酶 (bd-I oxidases) 和 bd-II 氧化酶 (bd-II oxidases)具有抑制作用，IC50 分别为 0.12、2.47、0.63 和 1.3 μM。ND-011992 可以用于研究肺结核。
T73133	FGF22-IN-1	Others	Others
	FGF22-IN-1 是一种潜在的 CD4 N-末端免疫球蛋白可变区样结构域（CD4 D1）抑制剂。FGF22-IN-1 可抑制CD4 与主要组织相容性复合体（MHC） II 类蛋白之间的相互作用，抑制免疫应答。
T15771	Lobaplatin D-19466,络铂	DNA Alkylation	DNA Damage/DNA Repair
	Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物，是一种有前途的抗肿瘤化疗药物，在多种肿瘤类型的患者中具有活性。
T36141	Boscalid	Mitochondrial Metabolism	Metabolism
	Boscalid 是一种广谱羧酰胺类杀菌剂，通过与线粒体复合物 II/琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。
TP1573L	CLIP 86-100 acetate(648881-58-7 free base)	Others	Others
	CLIP 86-100 acetate(648881-58-7 free base) 这是称为 CLIP 的 II 类相关不变链肽的氨基酸 86 至 100 片段。主要组织相容性复合物 II 类分子显示外源蛋白的肽片段，以触发免疫系统的防御反应。在将外源肽插入结合槽之前，去除一个占位肽 CLIP。这是通过分子 DM 实现的，它被证明可以增加 CLIP 肽与 II 类的解离速率。
T1184	Rivaroxaban BAY 59-7939,利伐沙班	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Rivaroxaban (BAY 59-7939) 是高效选择性的凝血因子 Xa (FXa) 直接抑制剂，IC50=0.7 nM，Ki 为 0.4 nM。
T68002	Naroparcil	Thrombin	Proteases/Proteasome
	Naroparcil 是一种可口服的硫代苷类化合物，是一种 4-甲基伞形 β-D-木糖苷类似物，在静脉血栓形成（颈静脉）的Wessler淤滞模型中显示出抗血栓形成作用。Naroparcil 增强了凝血酶/肝素辅因子II复合物的形成，诱导了处理兔血浆中硫酸皮肤素样物质的出现，但减少了与（125I）-人α-凝血酶孵育的血浆中的凝血酶/抗凝血酶III复合物的形成。
T38164	MnTBAP chloride Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) 是一种具有细胞渗透性的超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂，能使SOD-大肠杆菌的加倍时间减少了2倍。 MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导展现抗炎作用。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
T9543	Syk Inhibitor II hydrochloride	Others	Others
	Syk Inhibitor II hydrochloride 信号传导的影响在狼疮中可能很突出。
TP2158	TRV-120027 TFA TRV-120027 TFA (1234510-46-3 free base)	RAAS; Arrestin	Endocrinology/Hormones; GPCR/G Protein
	TRV-120027 TFA 是一种血管紧张素 II 介导的血管收缩抑制剂，可增加心肌细胞的收缩力。它是一种偏向 β-arrestin-1 的 AT1R 激动剂，可与 ß-arrestins 结合，同时阻断 G 蛋白信号传导。它通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌，并促进在质膜上形成由 AT1R-β-arrestin-1-TRPC3-PLCγ 组成的大分子复合物。
TP1158	Copper tripeptide [N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu	Others; Endogenous Metabolite	Metabolism; Others
	Copper tripeptide (GHK-Cu) 是天然存在的三肽，首先从人血浆中分离，但也能够在唾液和尿液中发现。它能够提高成纤维细胞中胶原蛋白，弹性蛋白，蛋白多糖和糖胺聚糖中信使 RNA 的产生。在伤口愈合期间，它能够通过蛋白水解从现有的细胞外蛋白质中除去，并且用作炎性和内皮细胞的化学引诱物。它是皮肤再生中多种细胞途径的天然调节剂。
T16867	SEC inhibitor KL-1 KL-1	Others	Others
	SEC inhibitor KL-1 (KL-1) 是一种拟肽先导化合物，是一种有效的选择性SEC 抑制剂，能够剂量依赖性地抑制 AFF4-CCNT1 相互作用。它能够破坏 SEC 支架蛋白 AFF4 和 P-TEFb 之间的相互作用，导致 Pol II 从启动子近端暂停位点的释放受损，并且进行性转录延伸的平均速率降低。
T16868	SEC inhibitor KL-2 KL-2	Others	Others
	SEC inhibitor KL-2 (KL-2) (KL-2) 是一种拟肽先导化合物，有效的选择性 SEC 抑制剂，通过破坏 SEC 支架蛋白 AFF4 和 P-TEFb 之间的相互作用，导致 Pol II 从启动子近端暂停位点的释放受损并且进行性转录延伸的平均速率降低。SEC inhibitor KL-2 剂量依赖性地抑制 AFF4-CCNT1 相互作用，Ki 值为 1.50 μM。
T17733	ATRA-hydroxyimino CRABP-II ligand 1	Others	Others
	ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifically Bestatin, through a linker, resulting in the formation of a complex called SNIPER. The purpose of this complex is to degrade CRABP-II within IMR-32 cells[1].
T31971	Glycyllysine Gly-lys,Glycyl-L-lysine
	Glycyllysine is a dipeptide. It can be used to study the interactions of the lysine side chain with copper in Glycyl-L-lysine-copper(II) complex.
T69936	NK314
	NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. The DNA breaks occurred within 1h after treatment with NK314 even without digestion of topoisomerase II by proteinase K, whereas etoposide required digestion of the enzyme protein in cleavable complex to detect DNA breaks. Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and suramin, reduc...
T40792	Cu(II)GTSM
	Cu(II)GTSM, a cell-permeable copper-complex, effectively inhibits GSK3β and shows inhibitory effects against Amyloid-β oligomers (AβOs) while reducing tau phosphorylation. Additionally, Cu(II)GTSM decreases the abundance of Amyloid-β trimers. With its potential as an anticancer and antimicrobial agent, Cu(II)GTSM exhibits promising therapeutic capabilities.
TP1126	InsB 9-23 Insulin B chain (9-23)
	InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7.
T72199	Antiproliferative agent-10
	Antiproliferative agent-10 是一种抗肿瘤钌(II)-三吡唑基甲烷复合物，可通过抑制线粒体钙摄入抑制癌细胞的生长。
TP2270	MHC class II antigen (45-57) [Homo sapiens]	Others	Others
	MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and l
T74921	Antiproliferative agent-12
	Antiproliferative agent-10 (compound 1) 是一种钌(II)-三吡唑基甲烷抗肿瘤复合物，能够通过阻断线粒体钙吸收来抑制癌细胞增殖。
TP1573	CLIP (86-100) CLIP 86-100
	CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide called CLIP. The major histocompatibility complex class II molecule displays peptide fragments of foreign proteins to trigger a defensive reaction from the immune system. Before insertion of the foreign peptides into the binding groove, a place-holding peptide CLIP is removed. CLIP (86-100) is accomplished by the molecule DM, which is shown to increase the dissociation rate of a CLIP peptide from class...
T79756	Beclin1-ATG14L interaction inhibitor 1	Autophagy	Autophagy
	Beclin1-ATG14L interaction inhibitor 1 (com 19) 作为一种选择性抑制剂，特定抑制脂质激酶VPS34的复合物 I 中Beclin1与ATG14L的相互作用，而对Beclin 1-UVRAG作用重要的VPS34复合物 II 无影响。由此，其阻断VPS34复合物 I 形成，抑制自噬过程，但不干扰复合物 II 介导的囊泡运输。
T36822	Benzovindiflupyr
	Benzovindiflupyr is a fungicide.1It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH; IC50= 5.2 nM), and mycelial growth ofS. sclerotiorum(EC50= 0.011 μg/ml). Benzovindiflupyr (60 μg/ml) completely protects eggplant leaves fromS. sclerotioruminfection. Formulations containing benzovindiflupyr have been used to control various fungal diseases in agriculture. 1.Gao, Y., He, L., Zhu, J., et al.The relationship between features enabling SDHI fungicide binding to the Sc-S...
T36784	Filipin II
	Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3]
T36116	Concanamycin B
	Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell su...
T26817	Bim-BLK-A Bim Blocker A,Compound A,Bim BLK A,BimBLKA
	Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer
T74225	ROS-ERS inducer 1
	ROS-ERS inducer 1 是一种基于4,5-二芳基咪唑的Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物，属于 II 型免疫原性细胞死亡(ICD)诱导剂。它能促使内质网应激(ERS)并伴随活性氧(ROS)的生成，进而在HCC细胞中触发损伤相关分子模式(DAMP)的释放。相比Cisplatin，ROS-ERS inducer 1 表现出更高的抗癌效能。
T68091	ledoxantrone
	Ledoxantrone 是一种新型化学类苯并吡喃吲哚类的合成插层剂，具有良好的临床前活性。其作用机制被认为是稳定DNA 与拓扑异构酶II 的可切割复合物，以及阻断DNA 解旋酶。
T72200	Antiproliferative agent-11
	Antiproliferative agent-11 是一种具有抗增殖活性和选择性的 Ruthenium(II)-Tris-pyrazolylmethane 复合物。Antiproliferative agent-11 对 MCF-7，HeLa，518A2，HCT116 和 RD 细胞具有抗增殖活性，其 IC50值分别为 6，10，6.8，6.7 和 6 μM。Antiproliferative agent-11 可用于癌症的研究。
T36485	Becatecarin
	Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.
T76598	H-Ser-Tyr-OH
	H-Ser-Tyr-OH是一种由谷氨酸、甘氨酸和组氨酸组成的二肽。它能与铜离子形成的铜（II）配合物生成，表现出较强的自由基清除活性。此外，H-Ser-Tyr-OH还能增加deltorphin这一δ阿片受体配体的细胞内摄取。
T37550	Bacitracin Complex
	Bacitracin complex is a bacitracin antibiotic complex composed of cyclic dipeptides that has been found inBacillus.1It is metal-dependent and is complexed to a divalent metal cation, such as Cu2+, Ni2+, Co2+, Zn2+, or Mn2+, for its activity.1,2Bacitracin complex is a mixture of bacitracin polypeptides in complex with copper. 1.Piacham, T., Isarankura-Na-Ayudhya, C., Nantasenamat, C., et al.Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutaseBiochem. Biophys. Res. ...
T74501	NHEJ inhibitor-1
	NHEJ inhibitor-1 (Compound C2) 是一种三功能 Pt(II) 复合物，可缓解非同源末端连接 (NHEJ)/同源重组 (HR) 相关的双链断裂 (DSB) 修复，从而避免非小细胞肺对顺铂的耐药性。NHEJ inhibitor-1 抑制损伤修复蛋白 Ku70 和 Rad51，从而使肿瘤对活性分子重新敏感。NHEJ inhibitor-1 还诱导 ROS 产生和MMP 降低。
T36714	Sucrose octasulfate (potassium salt)
	Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr...
T37469	Sitamaquine tosylate
	Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin f...
T73633	YKL-5-124 TFA
	YKL-5-124 TFA是一种高效、选择性不可逆的CDK7共价抑制剂，具有53.5 nM对CDK7的IC50值和9.7 nM对CDK7/Mat1/CycH的IC50值。此化合物对CDK7的选择性超过CDK9和CDK2 100倍以上，对CDK12和CDK13则无活性。YKL-5-124 TFA能显著诱导细胞周期停滞，抑制E2F驱动的基因表达，对RNA聚合酶II的磷酸化状态影响微乎其微。
T83865	HP661
	HP661是一种针对线粒体复合物I（也称为NADH脱氢酶）的抑制剂，对复合物I具有选择性，以1 µM的浓度抑制其77.6%，而对复合物III抑制率为28.1%，对复合物II和IV则无抑制作用。HP661特异性降低具有高水平氧化磷酸化作用的人类肺癌细胞H460、NCI H441及对trametinib耐药的A549细胞的生存能力（IC50分别为10.6、29.7和15.1 nM），相较于氧化磷酸化水平低的NCI H358人类肺癌细胞（IC50 >10,000 nM）以及非癌性人类胰腺正常上皮细胞（HPNE）和MRC-5人类胎肺成纤维细胞（两者的IC50均>10,000 nM）。当以每天两次，每次30 mg/kg的剂量给药时，HP661在H460小鼠异种移植模型中减少肿瘤体积，并对trametinib引导的肿瘤生长减少产生加成效应。
T35765	SAHA-BPyne
	Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azi...
T35712	Debutyldronedarone hydrochloride SR35021 hydrochloride
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...
T70222	Ethonafide
	Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerat...
T35687	Collismycin A
	Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 μg/ml) and fungi (MICs = 12.5-100 μg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50 = 56.6 μM) but not MDA-MD-231 breast canc...
T36695	TAS-103
	TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ...

化合物

Cobalt phthalocyanine

Cat.No: T19245

Synonym: Cobaltous phthalocyanine,酞菁钴,Phthalocyanine cobalt complex,Cobalt(II) phthalocyanine

Target: Others

Cat.No: T9714

Target: Potassium Channel

RuPhos Pd G1 Methyl t-Butyl Ether Adduct

Cat.No: T64624

Cat.No: T1523

Synonym: 替尼泊苷,NSC 122819,替尼泊甙,VM26

Target: Topoisomerase

Cat.No: T77615

Synonym: ND011992

Target: Mitochondrial Metabolism, Antibacterial

Cat.No: T73133

Target: Others

Cat.No: T15771

Synonym: D-19466,络铂

Target: DNA Alkylation

Cat.No: T36141

Target: Mitochondrial Metabolism

CLIP 86-100 acetate(648881-58-7 free base)

Cat.No: TP1573L

Target: Others

Cat.No: T1184

Synonym: BAY 59-7939,利伐沙班

Target: Factor Xa, Thrombin

Cat.No: T68002

Target: Thrombin

MnTBAP chloride

Cat.No: T38164

Synonym: Mn(III)TBAP

Syk Inhibitor II hydrochloride

Cat.No: T9543

Target: Others

Cat.No: TP2158

Synonym: TRV-120027 TFA (1234510-46-3 free base)

Target: RAAS, Arrestin

Copper tripeptide

Cat.No: TP1158

Synonym: [N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu

Target: Others, Endogenous Metabolite

SEC inhibitor KL-1

Cat.No: T16867

Synonym: KL-1

Target: Others

SEC inhibitor KL-2

Cat.No: T16868

Synonym: KL-2

Target: Others

ATRA-hydroxyimino

Cat.No: T17733

Synonym: CRABP-II ligand 1

Target: Others

Cat.No: T31971

Synonym: Gly-lys,Glycyl-L-lysine

Cat.No: T69936

Cat.No: T40792

Cat.No: TP1126

Synonym: Insulin B chain (9-23)

Antiproliferative agent-10

Cat.No: T72199

MHC class II antigen (45-57) [Homo sapiens]

Cat.No: TP2270

Target: Others

Antiproliferative agent-12

Cat.No: T74921

Cat.No: TP1573

Synonym: CLIP 86-100

Beclin1-ATG14L interaction inhibitor 1

Cat.No: T79756

Target: Autophagy

Benzovindiflupyr

Cat.No: T36822

Cat.No: T36784

Cat.No: T36116

Cat.No: T26817

Synonym: Bim Blocker A,Compound A,Bim BLK A,BimBLKA

ROS-ERS inducer 1

Cat.No: T74225

Cat.No: T68091

Antiproliferative agent-11

Cat.No: T72200

Cat.No: T36485

Cat.No: T76598

Bacitracin Complex

Cat.No: T37550

NHEJ inhibitor-1

Cat.No: T74501

Sucrose octasulfate (potassium salt)

Cat.No: T36714

Sitamaquine tosylate

Cat.No: T37469

Cat.No: T73633

Cat.No: T83865

Cat.No: T35765

Debutyldronedarone hydrochloride

Cat.No: T35712

Synonym: SR35021 hydrochloride

Cat.No: T70222

Cat.No: T35687

Cat.No: T36695

Cat. No.	Product Name	Target	Signaling Pathways
T0132	Etoposide VP-16,依托泊苷,依托泊甙,VP-16-213	Apoptosis; Mitophagy; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Microbiology/Virology
	Etoposide (VP-16-213) 是一种拓扑异构酶 II 的抑制剂，通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成 (IC50=60.3 μM)。Etoposide 具有抗肿瘤活性，可以诱导细胞凋亡、自噬。
T5291	Malonic acid Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid	Others	Others
	Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子：它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关，这是一种先天性代谢错误。
T4916	D-Glucaric acid potassium D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid	Others; Endogenous Metabolite	Metabolism; Others
	D-Glucaric acid potassium (D-Saccharic acid potassium salt) 是内源性代谢产物的一种。
T81957	Lacto-N-triose II
	Lacto-N-triose II 作为人乳低聚糖(HMOs)的核心结构单位，具备用于合成复杂HMOs的营养潜力。
T35667	Napyradiomycin A1 Napyradiomycin A1
	Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM...

天然产物

Cat.No: T0132

Synonym: VP-16,依托泊苷,依托泊甙,VP-16-213

Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: T5291

Synonym: Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid

Target: Others

D-Glucaric acid potassium

Cat.No: T4916

Synonym: D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid

Target: Others, Endogenous Metabolite

Lacto-N-triose II

Cat.No: T81957

Napyradiomycin A1

Cat.No: T35667

Synonym: Napyradiomycin A1

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