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CD74 Protein, Human, Recombinant (His)

CD74 Protein, Human, Recombinant (His)

产品编号 TMPY-01199
别名: II, DHLAG, Ia-GAMMA, CD74 molecule, major histocompatibility complex, class II invariant chain, Ia-γ, HLADG

CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2.

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CD74 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,690 现货
200 μg ¥ 6,520 5日内发货
500 μg ¥ 13,800 5日内发货
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产品目录号及名称: CD74 Protein, Human, Recombinant (His) (TMPY-01199)
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生物活性
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参考文献
生物活性 Measured by its binding ability in a functional ELISA. Immobilized human CD74 at 5 μg/ml (100 μl/well) can bind biotinylated human CTSL1 with a linear range of 3.2-400 ng/ml.
产品描述 CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2.
种属 Human
表达系统 HEK293 Cells
标签 N-His
蛋白编号 P04233-2
别名 II, DHLAG, Ia-GAMMA, CD74 molecule, major histocompatibility complex, class II invariant chain, Ia-γ, HLADG
蛋白构建 The extracellular domain (Gln 73-Met 232) of Human CD74 isoform b (NP_004346.1) was fused with a polyhistidine tag at the N-terminus.
蛋白纯度 > 80 % as determined by SDS-PAGE

TargetMol

分子量 20.4 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD74, also known as HLA class2 histocompatibility antigen gamma chain and HLA-DR antigens-associated invariant chain, is a polypeptide involved in the formation and transport of MHC class2 protein. CD74 is expressed by B cells, macrophages, and Reed-Sternberg cells. When MHC class 2 protein was in the rough ER, its peptide-binding cleft was blocked by CD74 to prevent it from interacting with the endogenous peptides. CD74 also serves to facilitate MHC class2's export from ER.

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Keywords

CD74 Protein, Human, Recombinant (His) II DHLAG Ia-GAMMA CD74 molecule, major histocompatibility complex, class II invariant chain Ia-γ HLADG recombinant recombinant-proteins proteins protein

 

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