azobenzene

Azobenzene是一种光触发器，可用于设计和合成各种光响应系统。Azobenzene 具有遗传毒性，可诱发脾脏和其他腹部器官的侵袭性肉瘤。

3'-Hydroxymethyl-4-(dimethylamino)azobenzene is a bioactive chemical.

SDMAp-hydroxyazobenzene-p′-sulfonate 是 SDMA 的对羟基偶氮苯-p′-磺酸盐衍生物，作为内源性一氧化氮合酶 (NO synthase) 的阻断剂。它也是 NF-κB 的激活剂，能够加强 IL-6 和 TNF-α 的表达。在血清和血浆中稳定，该化合物可以作为肝肾功能障碍的生物标志物使用。

Diazobenzenesulfonic acid is a whiter or reddish crystalline acid derivative of sulfanilic acid. It is a desensitizer (inhibitor) of allosteric effect for myosin ATPase 13.

4-(Dimethylamino)-3'-fluoroazobenzene is a bioactive chemical.

m-((3-Amino-4-hydroxyphenyl)azo)benzenesulphonic acid is a bioactive chemical.

m-((4-((4-(Bis(2-hydroxyethyl)amino)phenyl)azo)-1-naphthyl)azo)benzenesulphonic acid is a bioactive chemical.

m-((4-((4-Hydroxy-m-tolyl)azo)-3-methoxyphenyl)azo)benzenesulphonic acid is a bioactive chemical.

PAD2-IN-2 (cis-isomer of 1) TFA 为蛋白质精氨酸脱亚胺酶 2 (PAD2) 的抑制剂，拥有偶氮苯光开关，可光学调控 PAD 活性。PAD2-IN-2 TFA 能抑制组蛋白 H3-瓜氨酸化。

Thalidomide-Photoswitch3-NH2 hydrochloride是合成PHOTACs的重要成分，这些PHOTACs是通过不同光波长调节可逆性激活的PROTACs，其在黑暗中会失去活性，而在390 nm波长的照射下被激活为顺式异构体。在450 nm以上的波长范围内，这些PHOTACs会被可逆失活。该共轭物由Cereblon (CRBN) 招募配体、偶氮苯光开关交联剂以及一个与目标弹头酸基反应的悬浮胺基组成，被用于PHOTAC-I-10和PHOTAC-II-6的制备。

QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit this effect. This compound is membrane-impermeant and selectively enters pain-sensing neurons expressing endogenous import channels. QAQ dichloride functions as a light-sensitive analgesic and provides a valuable tool for investigating signaling mechanisms involved in acute and chronic pain [1] [2].

Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2 when used at concentrations up to 100 μM. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination with an IC50 value of 9.1 μM.References1. Mondal, S., Parelkar, S.S., Nagar, M., et al. Photochemical control of protein arginine deiminase (PAD) activity. ACS Chem. Biol. 13(4), 1057-1065 (2018). Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2 when used at concentrations up to 100 μM. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination with an IC50 value of 9.1 μM. References1. Mondal, S., Parelkar, S.S., Nagar, M., et al. Photochemical control of protein arginine deiminase (PAD) activity. ACS Chem. Biol. 13(4), 1057-1065 (2018).

KIO-301 chloride是一种偶氮苯光开关化合物，可在暴露于可见光期间阻断电压门控离子通道，包括超极化激活的环核苷酸门控(HCN)和电压门控钾通道(voltage-gated potassium channels)。