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Cat. No.	Product Name	Target	Signaling Pathways
T38421	PRMT1-IN-1 PRMT1-IN-1
	PRMT1-IN-1 is a PRMT1 inhibitor.
T2352	AMI-1	Histone Methyltransferase	Chromatin/Epigenetic
	AMI1 是一种有效的、可逆的、细胞渗透性的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂，对人 PRMT1 和酵母 Hmt1p 作用的 IC50值分别为 8.8 和 3.0 μM。它通过阻断肽-底物结合对 PRMTs 发挥抑制作用。
T27133	DCLX069 DCLX 069,DCLX-069	Histone Methyltransferase	Chromatin/Epigenetic
	DCLX069 是一种选择性蛋白精氨酸甲基转移酶 1 抑制剂，IC50值为 17.9 µM，对 PRMT4 和 PRMT6 的活性较低。它可有效阻断乳腺癌、肝癌和急性髓性白血病细胞系中的细胞增殖。
T7697	BIX-01294	Histone Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP，可诱导坏死性凋亡和自噬，具有抗肿瘤活性。
T1959	BIX-01294 trihydrochloride BIX 01294	Histone Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	BIX-01294 trihydrochloride 是可逆且高度选择性的G9a 和GLP 组蛋白甲基转移酶抑制剂，IC50分别为 1.9 μM 和 0.7 μM。它可诱导坏死性凋亡和自噬，具有抗肿瘤活性。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP。
T21826	TC-E 5003 NSC 30176	Histone Methyltransferase	Chromatin/Epigenetic
	TC-E 5003 (NSC-30176) 是选择性 PRMT1抑制剂，其 IC50值为1.5 µM。它在 TLR4 信号传导中具有抗炎特性。
T2097	C-7280948 C7280948	Histone Methyltransferase	Chromatin/Epigenetic
	C-7280948 是一种选择性有效的PRMT1抑制剂，IC50值 12.75 μM。
T6900	MS023	Histone Methyltransferase	Chromatin/Epigenetic
	MS023 是一种有效的、选择性的、细胞活性的 I 型 PRMT 抑制剂，对 PRMT1、PRMT3、PRMT4、PRMT6和 PRMT8的 IC50分别为 30、119、83、4 和 5 nM。
T10682L	CARM1-IN-1 CARM1-IN-7G	Histone Methyltransferase	Chromatin/Epigenetic
	CARM1-IN-1 (CARM1-IN-7G) 是 CARM1 的选择性抑制剂，IC50 为 8.6 μM。 CARM1-IN-1 对 PRMT1 和 SET7 的活性较弱，IC50 > 600 μM。
T11500L	GSK3368715 dihydrochloride EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) 是一种具有口服活性和高效性的 I 型蛋白精氨酸甲基转移酶 (PRMTs) 抑制剂，具有抗癌和抗肿瘤活性，抑制PRMT1，PRMT3，PRMT4，PRMT6，PRMT8的活性，可用于研究晚期实体肿瘤。
T61338	MS023 dihydrochloride MS023 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	MS023 dihydrochloride (MS023 2HCl) 是一种具有选择性、细胞活性和高效性的人I 型蛋白精氨酸甲基转移酶 (PRMTs)抑制剂，具有抗肿瘤活性，抑制 PRMT1，PRMT3，PRMT4，PRMT6和PRMT8，增加离体培养的 MuSC 的增殖能力，可用于研究乳腺癌。
T22342	GSK3368715 3HCl EPZ019997 3HCl,GSK3368715(EPZ019997)	Histone Methyltransferase	Chromatin/Epigenetic
	GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.
T22325	EPZ020411 hydrochloride EPZ020411 HCl	Histone Methyltransferase	Chromatin/Epigenetic
	EPZ020411 hydrochloride 是一种选择性的和有效的 PRMT6抑制剂，IC50=10 nM。
T77787	MS023 trihydrochloride MS023 3HCl	Histone Methyltransferase	Chromatin/Epigenetic
	MS023 trihydrochloride (MS023 3HCl) 是一种具有选择性和有效性的人I型蛋白精氨酸甲基转移酶 (PRMT)抑制剂，具潜在的抗癌活性，对 PRMT1、PRMT3、PRMT4、PRMT6 和 PRMT8 具有抑制作用，可用于研究癌症。
T81399	PRMT4-IN-2
	PRMT4-IN-2（化合物55）是一种针对蛋白质精氨酸甲基转移酶（PRMT）系列的抑制剂，其半抑制浓度（IC50s）分别对应PRMT4为92 nM，PRMT6为436 nM，PRMT1为460 nM，PRMT8为823 nM，PRMT3为1.386 μM。
T15080	DC-05	DNA Methyltransferase; Histone Methyltransferase	Chromatin/Epigenetic
	DC-05 是一种DNMT1的抑制剂，IC50和Kd 值分别为 10.3 和 1.09 μM。
T11500	GSK3368715 EPZ019997	Histone Methyltransferase	Chromatin/Epigenetic
	GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). It has strong anti-cancer activity.
TP2041	C 21
	Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.
T27395	Furamidine dihydrochloride DB 75, DB75, NSC 305831, WR199385,Furamidine HCl
	Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site and is primarily competitive with t
T11338	Furamidine DB75,NSC 305831	Others	Others
	Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and ...
T64186	CARM1-IN-1 hydrochloride
	CARM1-IN-1 hydrochloride 是一种高效的、选择性的 CARM1 抑制剂 (IC50: 8.6 μM)，对 PRMT1 和 SET7 抑制作用很低。
T10967	DC_C66	Others	Others
	DC_C66 DC_C66 has good selectivity for CARM1, PRMT1 (IC50 = 21μM), PRMT6 (IC50 = 47μM) and PRMT5. It is a cell-permeable, selective co-activator related arginine methyltransferase 1 (CARM1) inhibitor with IC50 of 1.8 μM.
T19243	CMP-5 hydrochloride	Others	Others
	CMP-5 hydrochloride is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations.
T23030	MS023 (hydrochloride) (1831110-54-3 free base) MS023 (hydrochloride)	Others	Others
	MS023 is a type I PRMT inhibitor (IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).
T72013	Epigenetic Multiple Ligand
	Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation.
T22239	AMI-1, free acid
	AMI-1 free acid 是一种有效的，具有细胞渗透性和可逆的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂，对人 PRMT1 和酵母 Hmt1p 作用的 IC50值分别为 8.8 μM 和 3.0 μM。AMI-1 free acid 通过阻断肽-底物结合发挥 PRMTs 抑制作用。
T4393	MS049 2HCl (1502816-23-0(free base))	Histone Methyltransferase	Chromatin/Epigenetic
	MS049 2HCl (1502816-23-0(free base)) 是一种有效的选择性 PRMT4 (IC50 = 34 nM) 和 PRMT6 (IC50 = 43 nM) 抑制剂。它对其他 I 型 PRMT 的活性较低（对于 PRMT1、PRMT3 和 PRMT8，IC50分别>130、>220 和 1.6 μM，），并且对 II 型或 III 型 PRMT 没有抑制作用，也没有对任何其他甲基转移酶或非表观遗传靶标进行测试。
T36802	Bisubstrate Inhibitor 78
	Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine N-methytransferase NSD2 and protein arginine methyltransferase 1 (PRMT1; IC50s = >50 μM for both). It reduces levels of 1-methylnicotinamide in, and inhibits proliferation of, HSC-2 oral cancer cells when us...
T4314	EPZ020411 EPZ020411 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	EPZ020411是一种特异性有效的 PRMT6 抑制剂， IC50 为 10 nM，比作用于 PRMT1 和 PRMT8 的选择性高10倍多。
T4334	EPZ020411 2HCl (1700663-41-7(free base))	Histone Methyltransferase	Chromatin/Epigenetic
	EPZ020411 2HCl (1700663-41-7(free base)) 是一种有效且特异性的小分子 PRMT6 抑制剂 (IC50=10 nM)。
T68378	PRMT4-IN-1	Histone Methyltransferase	Chromatin/Epigenetic
	PRMT4-IN-1为PRMT4高选择性抑制剂(IC50=3.2 nM)，能有效降低MCF7细胞的相对活力。

化合物

Cat.No: T38421

Synonym: PRMT1-IN-1

Cat.No: T2352

Target: Histone Methyltransferase

Cat.No: T27133

Synonym: DCLX 069,DCLX-069

Target: Histone Methyltransferase

Cat.No: T7697

Target: Histone Methyltransferase, Autophagy

BIX-01294 trihydrochloride

Cat.No: T1959

Synonym: BIX 01294

Target: Histone Methyltransferase, Autophagy

Cat.No: T21826

Synonym: NSC 30176

Target: Histone Methyltransferase

Cat.No: T2097

Synonym: C7280948

Target: Histone Methyltransferase

Cat.No: T6900

Target: Histone Methyltransferase

Cat.No: T10682L

Synonym: CARM1-IN-7G

Target: Histone Methyltransferase

GSK3368715 dihydrochloride

Cat.No: T11500L

Synonym: EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl

Target: Histone Methyltransferase

MS023 dihydrochloride

Cat.No: T61338

Synonym: MS023 2HCl

Target: Histone Methyltransferase

GSK3368715 3HCl

Cat.No: T22342

Synonym: EPZ019997 3HCl,GSK3368715(EPZ019997)

Target: Histone Methyltransferase

EPZ020411 hydrochloride

Cat.No: T22325

Synonym: EPZ020411 HCl

Target: Histone Methyltransferase

MS023 trihydrochloride

Cat.No: T77787

Synonym: MS023 3HCl

Target: Histone Methyltransferase

Cat.No: T81399

Cat.No: T15080

Target: DNA Methyltransferase, Histone Methyltransferase

Cat.No: T11500

Synonym: EPZ019997

Target: Histone Methyltransferase

Cat.No: TP2041

Furamidine dihydrochloride

Cat.No: T27395

Synonym: DB 75, DB75, NSC 305831, WR199385,Furamidine HCl

Cat.No: T11338

Synonym: DB75,NSC 305831

Target: Others

CARM1-IN-1 hydrochloride

Cat.No: T64186

Cat.No: T10967

Target: Others

CMP-5 hydrochloride

Cat.No: T19243

Target: Others

MS023 (hydrochloride) (1831110-54-3 free base)

Cat.No: T23030

Synonym: MS023 (hydrochloride)

Target: Others

Epigenetic Multiple Ligand

Cat.No: T72013

AMI-1, free acid

Cat.No: T22239

MS049 2HCl (1502816-23-0(free base))

Cat.No: T4393

Target: Histone Methyltransferase

Bisubstrate Inhibitor 78

Cat.No: T36802

Cat.No: T4314

Synonym: EPZ020411 2HCl

Target: Histone Methyltransferase

EPZ020411 2HCl (1700663-41-7(free base))

Cat.No: T4334

Target: Histone Methyltransferase

Cat.No: T68378

Target: Histone Methyltransferase

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