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Search Results for " erythropoietin "

Targets Recommended: HIF/HIF Prolyl-Hydroxylase

11

抑制剂 & 化合物

1

天然产物

29

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2445	FG-2216 YM-311,FG2216,FG 2216	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	FG-2216 (YM-311) 是一种有效的、口服具有活力的HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂，IC50=3.9 nM。它在体内能够诱导促红细胞生成素生成和胎儿血红蛋白的表达。
TP1195	Cibinetide ARA290	Others	Others
	Cibinetide (ARA290) 是特异性的 erythropoietin/CD131 heteroreceptor 的激动剂，是一种 EPO 衍生物，常用于神经系统疾病研究。
T2652	Molidustat BAY 85-3934	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。
T2556	Nandrolone decanoate 癸酸诺龙,19-Nortestosterone decanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素，通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。
T76314	Epobis
	Epobis，一种重组树突状肽，有效地激动erythropoietin receptor，具有促进初级运动神经元神经纤维生成、减少TNF释放以及穿透血脑屏障的功能。Epobis展现出显著的抗炎和增强记忆力特性。
T82455	Epoetin beta Genetical recombination,rhEPO,EPOCH
	Epoetin beta (rhEPO)为促红细胞生成素的重组形式，起着维持红细胞生成的作用，常用于贫血研究。
T82454	Epoetin zeta
	Epoetin zeta，内源性促红细胞生成素(Erythropoietin)的衍生物，作为促红细胞生成剂使用。它主要应用于肾源性贫血及其相关研究领域。
T76438	QEQLERALNSS TFA
	QEQLERALNSS TFA 是一种衍生自促红细胞生成素的HBSP，具有组织保护活性，能够保护心肌细胞免受凋亡(apoptosis)。
T79798	PHD-IN-2	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	PHD-IN-2（Compound 91）是一种高效的PHD拮抗剂，具有IC50值小于5 nM，能在HEP3B细胞中诱导促红细胞生成素的合成，EC50值小于2.5 μM。此化合物主要用于心血管、代谢、血液、肺部、肾脏、肝脏疾病、伤口愈合以及癌症等研究领域。
T84319	5α-Dihydrotestosterone Stanolone,DHT,Dihydrotestosterone,Androstanolone
	二氢睾酮 (DHT) 是一种内源性雄激素类固醇和激素，可作为雄激素受体的激动剂。 DHT 可促进肾脏释放促红细胞生成素 (EPO)。刺激骨髓中G0期造血干细胞增殖分化为红细胞系，促进红细胞增加。主要用于慢性再生障碍性贫血及任何原因引起的骨髓造血功能衰竭。
T69966	Roxadustat-d5
	Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...

化合物

Cat.No: T2445

Synonym: YM-311,FG2216,FG 2216

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: TP1195

Synonym: ARA290

Target: Others

Cat.No: T2652

Synonym: BAY 85-3934

Target: HIF/HIF Prolyl-Hydroxylase

Nandrolone decanoate

Cat.No: T2556

Synonym: 癸酸诺龙,19-Nortestosterone decanoate

Target: Others, HIV Protease

Cat.No: T76314

Cat.No: T82455

Synonym: Genetical recombination,rhEPO,EPOCH

Cat.No: T82454

QEQLERALNSS TFA

Cat.No: T76438

Cat.No: T79798

Target: HIF/HIF Prolyl-Hydroxylase

5α-Dihydrotestosterone

Cat.No: T84319

Synonym: Stanolone,DHT,Dihydrotestosterone,Androstanolone

Cat.No: T69966

Cat. No.	Product Name	Target	Signaling Pathways
T4956	Tetrahydroxystilbene-2-O-β-D-glucoside tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201	Others	Others
	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) 是一种低分子量的促红细胞生成素诱导剂。

天然产物

Tetrahydroxystilbene-2-O-β-D-glucoside

Cat.No: T4956

Synonym: tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00443	EPO/Erythropoietin Protein, Mouse, Recombinant 红细胞生长素,erythropoietin	Mouse	HEK293 Cells
	EPO/Erythropoietin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.6 kDa and the accession number is P07321.
TMPJ-00071	EPO/Erythropoietin Protein, Human, Recombinant (His) Erythropoietin,EPO,红细胞生长素,Epoetin	Human	HEK293 Cells
	Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EP...
TMPY-00639	EPO/Erythropoietin Protein, Human, Recombinant (hFc) 红细胞生长素,MVCD2,Erythropoietin,EP	Human	HEK293 Cells
	EPO/Erythropoietin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.1 kDa and the accession number is G9JKG7.
TMPY-01883	EPOR Protein, Human, Recombinant (His) erythropoietin receptor,EPO-R	Human	HEK293 Cells
	EPOR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1.
TMPY-02986	EPO/Erythropoietin Protein, Mouse, Recombinant (His) 红细胞生长素,erythropoietin	Mouse	HEK293 Cells
	EPO/Erythropoietin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is P07321.
TMPY-02073	EPO/Erythropoietin Protein, Rat, Recombinant (His) 红细胞生长素,erythropoietin	Rat	Baculovirus Insect Cells
	EPO/Erythropoietin Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20 kDa and the accession number is P29676-1.
TMPY-00462	EPO/Erythropoietin Protein, Cynomolgus, Recombinant (His) 红细胞生长素,erythropoietin	Cynomolgus	HEK293 Cells
	EPO/Erythropoietin Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is XP_005549312.1.
TMPK-00077	EPO/Erythropoietin Protein, Human, Recombinant EPO,MVCD2,红细胞生长素,Epoetin,Erythropoietin,EP	Human	HEK293 Cells
	Erythropoietin (EPO) is a circulating hormone conventionally considered to be responsible for erythropoiesis. In addition to facilitating red blood cell production, EPO has pluripotent potential, such as for cognition improvement, neurogenesis, and anti-fibrotic, anti-apoptotic, anti-oxidative, and anti-inflammatory effects.
TMPY-00521	EPOR Protein, Mouse, Recombinant (hFc) erythropoietin receptor	Mouse	Baculovirus Insect Cells
	EPOR Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 51.4 kDa and the accession number is P14753-1.
TMPY-01224	EPOR Protein, Mouse, Recombinant (His) erythropoietin receptor	Mouse	HEK293 Cells
	EPOR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P14753-1.
TMPY-06109	EPOR Protein, Human, Recombinant (His), Biotinylated EPO-R,erythropoietin receptor	Human	HEK293 Cells
	EPOR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1.
TMPY-00794	EPOR Protein, Human, Recombinant (hFc) EPO-R,erythropoietin receptor	Human	HEK293 Cells
	EPOR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.0 kDa and the accession number is P19235-1.
TMPY-02049	EPOR & CD131 Heterodimer Protein, Human, Recombinant (hFc) EPO-R,erythropoietin receptor	Human	HEK293 Cells
	EPOR & CD131 Heterodimer Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is NP_000112.1&NP_000386.1.
TMPH-00827	Erythropoietin Protein, Horse, Recombinant (hFc)	Horse	HEK293 Cells
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Horse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 47.3 kDa and the accession number is Q867B1.
TMPH-03110	Erythropoietin Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	P. pastoris (Yeast)
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P49157.
TMPH-00828	Erythropoietin Protein, Horse, Recombinant (His & SUMO)	Horse	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Horse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.3 kDa and the accession number is Q867B1...
TMPH-00463	Erythropoietin Protein, Danio rerio, Recombinant (His)	Danio rerio (Zebrafish)	E. coli
	Erythropoietin Protein, Danio rerio, Recombinant (His) is expressed in E. coli.
TMPH-02426	Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc)	Cynomolgus	HEK293 Cells
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 22.2 kDa and the accession number is P07865...
TMPH-02427	Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO)	Cynomolgus	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.2 kDa and the accession number is P...
TMPH-03111	Erythropoietin Protein, Pig, Recombinant (B2M & His)	Sus scrofa (Pig)	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Pig, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 32.6 kDa and the accession number is P49157.
TMPH-03287	EPOR Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase. EPOR Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO and C-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession number is Q07303.
TMPY-01299	GMF gamma/GMFG Protein, Human, Recombinant (His) glia maturation factor, γ,glia maturation factor, gamma,GMF-...	Human	E. coli
	The glia maturation factor gamma (GMFG) is a cytokine-responsive protein in erythropoietin-induced and granulocyte-colony stimulating factor-induced hematopoietic lineage development. It may mediate the pluripotentiality and lineage commitment of human hematopoietic stem cells. GMFG expression independently predicts poorer prognosis in patients with EOC. Ectopic overexpression of GMFG contributes to the malignant biological behavior of ovarian cancer cells.
TMPH-02274	JAK2 Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...
TMPK-01387	EPhA3 Protein, Canine, Recombinant (His) HEK4,TYRO4,ETK1,EPHA3,HEK,ETK,EK4	Canine	HEK293 Cells
	Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. The interaction of AR and SP1 contributes to regulate EPHA3 expression, and the SP1 binding sites (‑295~‑261) in the EPHA3 core promoter region is crucial to the regulation of EPHA3 expression in response to androgen hormone stimuli.
TMPJ-00091	G-CSF Protein, Mouse, Recombinant (His) Csf3,G-CSF,Granulocyte colony-stimulating factor,集落刺激因子	Mouse	HEK293 Cells
	Granulocyte colony-stimulating factor (G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of ...
TMPY-04421	FES Protein, Human, Recombinant (His & GST) FPS,FES proto-oncogene, tyrosine kinase	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and oneSH2 domain. FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. FES is observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-6. T...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx) SOCS-3,SSI-3,ATOD4,Cish3,SSI3,suppressor of cytokine signali...	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. ...
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His) bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b...	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...
TMPY-04391	Lyn Protein, Human, Recombinant (GST) JTK8,LYN proto-oncogene, Src family tyrosine kinase,p56Lyn,p...	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif...

重组蛋白

EPO/Erythropoietin Protein, Mouse, Recombinant

Cat.No: TMPY-00443

Species: Mouse

Expression System: HEK293 Cells

EPO/Erythropoietin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00071

Species: Human

Expression System: HEK293 Cells

EPO/Erythropoietin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00639

Species: Human

Expression System: HEK293 Cells

EPOR Protein, Human, Recombinant (His)

Cat.No: TMPY-01883

Species: Human

Expression System: HEK293 Cells

EPO/Erythropoietin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02986

Species: Mouse

Expression System: HEK293 Cells

EPO/Erythropoietin Protein, Rat, Recombinant (His)

Cat.No: TMPY-02073

Species: Rat

Expression System: Baculovirus Insect Cells

EPO/Erythropoietin Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-00462

Species: Cynomolgus

Expression System: HEK293 Cells

EPO/Erythropoietin Protein, Human, Recombinant

Cat.No: TMPK-00077

Species: Human

Expression System: HEK293 Cells

EPOR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00521

Species: Mouse

Expression System: Baculovirus Insect Cells

EPOR Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01224

Species: Mouse

Expression System: HEK293 Cells

EPOR Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-06109

Species: Human

Expression System: HEK293 Cells

EPOR Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00794

Species: Human

Expression System: HEK293 Cells

EPOR & CD131 Heterodimer Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02049

Species: Human

Expression System: HEK293 Cells

Erythropoietin Protein, Horse, Recombinant (hFc)

Cat.No: TMPH-00827

Species: Horse

Expression System: HEK293 Cells

Erythropoietin Protein, Pig, Recombinant (His)

Cat.No: TMPH-03110

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

Erythropoietin Protein, Horse, Recombinant (His & SUMO)

Cat.No: TMPH-00828

Species: Horse

Expression System: E. coli

Erythropoietin Protein, Danio rerio, Recombinant (His)

Cat.No: TMPH-00463

Species: Danio rerio (Zebrafish)

Expression System: E. coli

Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc)

Cat.No: TMPH-02426

Species: Cynomolgus

Expression System: HEK293 Cells

Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO)

Cat.No: TMPH-02427

Species: Cynomolgus

Expression System: E. coli

Erythropoietin Protein, Pig, Recombinant (B2M & His)

Cat.No: TMPH-03111

Species: Sus scrofa (Pig)

Expression System: E. coli

EPOR Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03287

Species: Rat

Expression System: E. coli

GMF gamma/GMFG Protein, Human, Recombinant (His)

Cat.No: TMPY-01299

Species: Human

Expression System: E. coli

JAK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02274

Species: Human

Expression System: E. coli

EPhA3 Protein, Canine, Recombinant (His)

Cat.No: TMPK-01387

Species: Canine

Expression System: HEK293 Cells

G-CSF Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00091

Species: Mouse

Expression System: HEK293 Cells

FES Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04421

Species: Human

Expression System: Baculovirus Insect Cells

SOCS3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-02194

Species: Human

Expression System: E. coli

HIF-1 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01709

Species: Human

Expression System: E. coli

Lyn Protein, Human, Recombinant (GST)

Cat.No: TMPY-04391

Species: Human

Expression System: Baculovirus Insect Cells

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