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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-EPOR Polyclonal Antibody

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货号 TMAB-00628

别名 erythropoietin receptor, EPO-R

Anti-EPOR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 EPOR。Anti-EPOR Polyclonal Antibody 可用于 IF,IHC-Fr,WB。

Anti-EPOR Polyclonal Antibody

Anti-EPOR Polyclonal Antibody

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货号 TMAB-00628 别名 erythropoietin receptor, EPO-R

Anti-EPOR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 EPOR。Anti-EPOR Polyclonal Antibody 可用于 IF,IHC-Fr,WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-EPOR Polyclonal Antibody is a Rabbit antibody targeting EPOR. Anti-EPOR Polyclonal Antibody can be used in IF,IHC-Fr,WB.
别名erythropoietin receptor, EPO-R
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Dog,Cow,Horse)
验证活性
1. Sample:
K562 (Human) Cell Lysate at 30 μg
Primary: Anti-EPOR (TMAB-00628) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kDa
Observed band size: 64 kDa
2. Sample:
K562 (Human) Cell Lysate at 30 μg
Primary: Anti-EPOR (TMAB-00628) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kDa
Observed band size: 30/52 kDa
verifiedActivityverifiedActivity
应用IFIHC-FrWB
推荐剂量
WB: 1:500-2000; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted. Note=Secreted and located to the cell surface.
组织特异性Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EP
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.
抗原信息
免疫原
KLH conjugated synthetic peptide: human EPOR
抗原种属
Human
基因名称
EPOR
基因ID
2057
蛋白名称
Erythropoietin receptor
Uniprot ID
P19235
研究领域
Angiogenic Factors,Endothelial Cell Markers,Ischemia / Reperfusion,Apoptosis,Hypertrophy,Receptors,Small G Proteins,Surface Molecules
功能
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
化学信息
分子量Theoretical: 56 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

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