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EPOR Protein, Human, Recombinant (His)

EPOR Protein, Human, Recombinant (His)

产品编号 TMPY-01883
别名: erythropoietin receptor, EPO-R

EPOR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1.

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TargetMol
EPOR Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 现货
200 μg ¥ 6,750 5日内发货
500 μg ¥ 14,280 5日内发货
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产品目录号及名称: EPOR Protein, Human, Recombinant (His) (TMPY-01883)
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生物活性
技术参数
产品性质
参考文献
生物活性 Measured by its ability to inhibit EPO-dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 15-60 ng/mL in the presence of 0.1 U/mL Recombinant Human EPO.

TargetMol Bioactive

产品描述 EPOR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P19235-1
别名 erythropoietin receptor, EPO-R
蛋白构建 The extracellular domain (Met 1-Pro 250) of Human erythropoietin receptor (NP_000112.1) precursor was fused with a polyhistidine tag at the C-terminus.
蛋白纯度 > 98 % as determined by SDS-PAGE

TargetMol

分子量 26.3 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 0.05% CHAPS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type â… single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.

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Keywords

EPOR Protein, Human, Recombinant (His) erythropoietin receptor EPO-R recombinant recombinant-proteins proteins protein

 

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