HOE-S 785026 trihydrochloride 是一种活细胞标记染料,通过结合 DNA 双链中的小沟而结合核酸。 HOE-S 785026 trihydrochloride 倾向于结合富含 A T 的 DNA 链(富含 A T 的双链 DNA 使荧光强度显著增强)。HOE-S 785026 trihydrochloride 可穿过细胞膜,与活细胞或固定细胞结合。HOE-S 785026 trihydrochloride 的荧光强度随着溶液 pH 升高而增加。
Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5 6 (IC50 = 3 μM), thereby activating Wnt β-catenin signaling. Modulation of the Dkk1-LRP5 6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.
HOE 32020 is a Hoechst stain, a blue fluorescent dyes, used to stain DNA. Hoechst dyes are soluble in water and in organic solvents such as dimethyl formamide or dimethyl sulfoxide. Concentrations can be achieved of up to 10 mg mL. Aqueous solutions are s