Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH900776 S-isomer (MK-8776 S-isomer) 是SCH900776的S 型同分异构体。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 583 | 现货 | ||
2 mg | ¥ 852 | 现货 | ||
5 mg | ¥ 1,280 | 现货 | ||
10 mg | ¥ 2,260 | 现货 | ||
25 mg | ¥ 3,890 | 现货 | ||
50 mg | ¥ 5,560 | 现货 | ||
100 mg | ¥ 7,790 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,060 | 现货 |
产品描述 | SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM). |
靶点活性 | Chk1:3 nM, Chk2:1500 nM, CDK2:160 nM |
体外活性 | SCH 900776 does not significantly inhibit HLMs CYP450 isoforms 1A2, 2C9, 2C19, 2D6, and 3A4. SCH 900776 induces a dose-dependent loss of DNA replication capability 24 hours after hydroxyurea exposure. In combination with an antimetabolite, SCH 900776 induces accumulation of γ-H2AX within 2 hours, indicative of replication fork collapse and double-stranded DNA breaks. SCH 900776 also dose-dependently suppresses accumulation of the Chk1 pS296 autophosphorylation. |
体内活性 | After pretreatment 30 minutes with gemcitabine, SCH 900776 (4 mg/kg) is sufficient to induce the γ-H2AX biomarker while 8 mg/kg leads to enhanced tumor pharmacodynamic and regression responses relative to gemcitabine or SCH 900776 alone. SCH 900776 (16/32 mg/kg) dose-dependently induces improvements in tumor response. Doses of SCH 900776 associate with robust biomarker activation and improved tumor response are not associated with enhanced toxicity of gemcitabine on hematological parameters in BALB/c mice. |
别名 | MK-8776 S-isomer, SCH900776 S-isomer |
分子量 | 376.25 |
分子式 | C15H18BrN7 |
CAS No. | 891494-64-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (265.78 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6578 mL | 13.289 mL | 26.5781 mL | 66.4452 mL |
5 mM | 0.5316 mL | 2.6578 mL | 5.3156 mL | 13.289 mL | |
10 mM | 0.2658 mL | 1.3289 mL | 2.6578 mL | 6.6445 mL | |
20 mM | 0.1329 mL | 0.6645 mL | 1.3289 mL | 3.3223 mL | |
50 mM | 0.0532 mL | 0.2658 mL | 0.5316 mL | 1.3289 mL | |
100 mM | 0.0266 mL | 0.1329 mL | 0.2658 mL | 0.6645 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SCH900776 (S-isomer) 891494-64-7 Cell Cycle/Checkpoint Chk CDK SCH900776 (S isomer) inhibit SCH-900776 SCH-900776 (S-isomer) SCH 900776 SCH900776 (Sisomer) SCH900776 MK-8776 S-isomer S-isomer SCH900776 S-isomer Inhibitor inhibitor