keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 590 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 539 | 现货 |
产品描述 | 1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand. |
别名 | 蓝萼甲素, Wangzaozin B, Leukamenin F |
分子量 | 332.43 |
分子式 | C20H28O4 |
CAS No. | 79498-31-0 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
DMSO: 6.88 mg/mL (20.68 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0082 mL | 15.0408 mL | 30.0815 mL | 75.2038 mL |
5 mM | 0.6016 mL | 3.0082 mL | 6.0163 mL | 15.0408 mL | |
10 mM | 0.3008 mL | 1.5041 mL | 3.0082 mL | 7.5204 mL | |
20 mM | 0.1504 mL | 0.752 mL | 1.5041 mL | 3.7602 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Glaucocalyxin A 79498-31-0 Apoptosis Cytoskeletal Signaling PI3K/Akt/mTOR signaling Proteases/Proteasome Akt Caspase PI3K 蓝萼甲素 Phosphoinositide 3-kinase inhibit Protein kinase B Wangzaozin B Inhibitor PKB Leukamenin F inhibitor