store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
CORM3 是一种 CO 释放分子,能够减少 NLRP3炎症小体的激活,可以减弱 NF-κB p65的核异位,减少 ROS 的生成,并提高细胞内谷胱甘肽和超氧化物歧化酶的水平。
产品描述 | CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity. |
体外活性 | CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4] |
体内活性 | CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3] |
别名 | CORM3, (OC-6-44)-三羰基氯(甘氨酸基)钌 |
分子量 | 294.61 |
分子式 | C5H4ClNO5Ru |
CAS No. | 475473-26-8 |
store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 129 mM
( < 1 mg/mL refers to the product slightly soluble or insoluble )
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
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您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CORM-3 475473-26-8 Immunology/Inflammation NF-Κb Others NF-κB NOD-like Receptor (NLR) inhibit Inhibitor CORM3 Nuclear factor-kappaB Nuclear factor-κB CORM 3 (OC-6-44)-三羰基氯(甘氨酸基)钌 inhibitor