规格

价格

库存

数量

2 mg

¥ 258

5日内发货

5 mg

¥ 423

5日内发货

10 mg

¥ 678

5日内发货

1 mL x 10 mM (in DMSO)

¥ 747

5日内发货

生物活性

产品描述	(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
靶点活性	D1 receptor:83 nM (Ki), D2 receptor:13.5 nM (Ki), D5 receptor:5.4 nM (Ki), 5-HT1A receptor:30 nM (Ki), D4 receptor:3.9-15 nM (Ki), D3 receptor:0.71 nM (Ki), 5-HT2B receptor:27 nM (Ki)
体外活性	In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7)[1]. Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+?toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone[4]. .

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (142.07 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (7.1 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO