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GSNOR

GSNOR

S-Nitrosoglutathione (GSNO) is an endogenous S-nitrosothiol (SNO) that plays a critical role in nitric oxide (NO) signaling and is a source of bioavailable NO. NO coexists in cells with SNOs that serve as endogenous NO carriers and donors. SNOs spontaneously release NO at different rates and can be powerful terminators of free radical chain propagation reactions, by reacting directly with ROO• radicals, yielding nitro derivatives as end products. NO is generated intracellularly by the nitric oxide synthase (NOS) family of enzymes: nNOS, eNOS and iNOS while the in vivo source of many of the SNOs is unknown. In oxygenated buffers, however, formation of SNOs is due to oxidation of NO to dinitrogen trioxide (N2O3). Some evidence suggests that both exogenous NO and endogenously derived NO from nitric oxide synthases can react with glutathione to form GSNO.
Cat. No. Product Name CAS No. Purity Chemical Structure
T26955 Cavosonstat
卡伏索司他
1371587-51-7 98.91%
Cavosonstat (N91115) 是一种口服活性 S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂,可促进囊性纤维化跨膜传导调节器(CFTR)成熟和质膜稳定。
T6901 N6022
化合物N6022
1208315-24-5 98.32%
N6022 是选择性可逆的S-Nitrosoglutathione reductase 抑制剂,IC50=8 nM。
Cavosonstat
T26955
Cavosonstat (N91115) 是一种口服活性 S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂,可促进囊性纤维化跨膜传导调节器(CFTR)成熟和质膜稳定。
N6022
T6901
N6022 是选择性可逆的S-Nitrosoglutathione reductase 抑制剂,IC50=8 nM。
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