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Search Results for " transthyretin "

17

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T61423	Transthyretin-IN-1
	Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T9447	AG-10 Acoramidis	Others	Others
	AG-10 (Acoramidis) 是选择性的、口服有效的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，显示出对野生型和 V1221 突变型均有效。
T7582	tafamidis meglumine Fx-1006A,他发米帝司甲葡胺	Others	Others
	Tafamidis meglumine (Fx-1006A) 是transthyretin (TTR)的选择性稳定剂，对野生型 WT-TTR 和突变型同源四聚体 V30M-TTR，V122I-TTR 的活性相当，EC50值为 2.7-3.2 μM。它能够阻碍淀粉样蛋白的生成。
T39740	Acoramidis hydrochloride AG10 hydrochloride,Alxn2060 hydrochloride	Others	Others
	Acoramidis hydrochloride (Alxn2060 hydrochloride) 是具有口服活性的、选择性的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，对野生型和 V1221 突变型均有效。Acoramidis hydrochloride 可用于转体甲状腺素淀粉样变性的研究。
T10203	A 1120	Others	Others
	A 1120 是一种高亲和力的视黄醇结合蛋白 4 的拮抗剂(Ki:8.3 nM)。它能够破坏 RBP4 与其结合体转甲状腺素之间的相互作用。
T4565	Tafamidis 他发米帝司甲葡胺,氯苯唑酸,Fx-1006A	Others	Others
	Tafamidis (Fx-1006A) 是选择性的transthyretin (TTR)稳定剂，对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当，它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。
T79417	PITB
	PITB是一种选择性且具口服活性的TTR聚集抑制剂，主要用于研究ATTR疾病。
T15116	Dichlorophenyl-ABA	Others	Others
	Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells.
T39304	Vutrisiran ALN-TTRsc02
	Vutrisiran (ALN-TTRsc02) is an investigational, liver-directed small interfering ribonucleic acid (siRNA) compound designed for research on transthyretin (TTR)-mediated amyloidosis.
T32500	L6Y TTR stabilizer L6
	L6Y is a transthyretin (TTR) stabilizer which binds to the T4 binding pocket of TTR and prevents the dissociation of TTR to monomer.
T38918	Revusiran ALN-TTRSC
	Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA. It is utilized in TTR-mediated amyloidosis research.
T74405	PEG2000-C-DMG
	PEG2000-C-DMG，一种 PEG 化修饰的脂质，可用于制备 Onpattro。Onpattro 是一种肝脏导向的研究性 RNAi 有效试剂，通过靶向甲状腺素运载蛋白 mRNA 的3′非翻译区，利用这一过程减少突变型和野生型甲状腺素运载蛋白的产生。
T38909	Inotersen sodium ISIS-420915 sodium
	Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, thereby reducing TTR transcript levels. Inotersen sodium holds potential for research on hereditary TTR amyloidosis polyneuropathy.
T75173	WT-TTR inhibitor 1
	WT-TTR inhibitor 1 (Compound 21)作为一种野生型转甲状腺素(WT-TTR)的抑制剂，其在100 μM浓度下的抑制率达到29.05%。
T38804	Patisiran sodium
	Patisiran sodium is a double-stranded small interfering RNA (siRNA) that selectively targets a specific sequence within the transthyretin (TTR) messenger RNA (mRNA). By doing so, it effectively blocks the hepatic synthesis of both mutant and wild-type TTR. Patisiran sodium has significant applications in the field of hereditary TTR amyloidosis research.
T71785	GUN35758
	GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T74645	Eplontersen
	Eplontersen 是一种三触角的、N-乙酰半乳糖胺 (GalNAc3)-缀合的反义寡核苷酸，能够靶向甲状腺素运载蛋白 TTR 的 mRNA，抑制变体和野生型 TTR 产生。错误折叠的 TTR 诱导心脏和周围神经的淀粉样原纤维形成，并介导淀粉样 TTR (ATTR) 蛋白变性疾病。

化合物

Transthyretin-IN-1

Cat.No: T61423

Cat.No: T9447

Synonym: Acoramidis

Target: Others

tafamidis meglumine

Cat.No: T7582

Synonym: Fx-1006A,他发米帝司甲葡胺

Target: Others

Acoramidis hydrochloride

Cat.No: T39740

Synonym: AG10 hydrochloride,Alxn2060 hydrochloride

Target: Others

Cat.No: T10203

Target: Others

Cat.No: T4565

Synonym: 他发米帝司甲葡胺,氯苯唑酸,Fx-1006A

Target: Others

Cat.No: T79417

Dichlorophenyl-ABA

Cat.No: T15116

Target: Others

Cat.No: T39304

Synonym: ALN-TTRsc02

Cat.No: T32500

Synonym: TTR stabilizer L6

Cat.No: T38918

Synonym: ALN-TTRSC

Cat.No: T74405

Inotersen sodium

Cat.No: T38909

Synonym: ISIS-420915 sodium

WT-TTR inhibitor 1

Cat.No: T75173

Patisiran sodium

Cat.No: T38804

Cat.No: T71785

Cat.No: T74645

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01756	Transthyretin Protein, Human, Recombinant (His) PALB,HEL111,CTS,transthyretin,CTS1,HsT2651,TBPA	Human	HEK293 Cells
	Transthyretin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is E9KL36.
TMPY-04919	Transthyretin Protein, Mouse, Recombinant (His) AI787086,prealbumin,D17860,AA408768,transthyretin	Mouse	HEK293 Cells
	Transthyretin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is P07309.
TMPK-01090	Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His) Prealbumin,TBPA,CTS,HEL111,Transthyretin,TTR,ATTR,C...	Cynomolgus	HEK293 Cells
	Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.
TMPH-02947	Transthyretin Protein, Mouse, Recombinant	Mouse	E. coli
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.5 kDa and the accession number is P07309.
TMPH-02242	Transthyretin Protein, Human, Recombinant (hFc & Myc)	Human	HEK293 Cells
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
TMPH-02946	Transthyretin Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.6 kDa and the accession number is P07309.
TMPJ-00084	RBP4 Protein, Human, Recombinant Retinol-Binding Protein 4,Plasma Retinol-Binding Protein,PRB...	Human	E. coli
	Retinol Binding Protein 4 (RBP4) is a member of the Lipocalin family and in the blood. RBP4 is the specific vector for retinol. RBP4 is expressed and secreted by adipose tissue, and is associated with insulin resistance. RBP4 delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin to prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 cause retinol-binding protein deficiency and can cause night vi...

重组蛋白

Transthyretin Protein, Human, Recombinant (His)

Cat.No: TMPY-01756

Species: Human

Expression System: HEK293 Cells

Transthyretin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04919

Species: Mouse

Expression System: HEK293 Cells

Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01090

Species: Cynomolgus

Expression System: HEK293 Cells

Transthyretin Protein, Mouse, Recombinant

Cat.No: TMPH-02947

Species: Mouse

Expression System: E. coli

Transthyretin Protein, Human, Recombinant (hFc & Myc)

Cat.No: TMPH-02242

Species: Human

Expression System: HEK293 Cells

Transthyretin Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02946

Species: Mouse

Expression System: E. coli

RBP4 Protein, Human, Recombinant

Cat.No: TMPJ-00084

Species: Human

Expression System: E. coli

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