tetrapeptide-2

Tetrapeptide-2 is an amino acid peptide.

Acetyl tetrapeptide-2 is a skin conditioner, by soothing and nourishing the skin through similar mechanisms as other peptides.

Acetyl tetrapeptide-2 Acetate 常用作皮肤调理剂。 Acetyl tetrapeptide-2 Acetate 是通过补偿皮肤中的激素损失来完成的，尤其是胶原蛋白，为皮肤提供了一些丰满的效果。

Tetrapeptide-21 Acetate 是一种新型生物活性纯四肽，具有基于皮肤自身结构的抗衰老特性，可用于护肤配方。

Acetyl tetrapeptide-2，生物活性肽，具修复肌肤功效，报道作为化妆品成分应用。

Tetrapeptide-26，一种生物活性肽，具抗衰老(anti-aging)功能，常用作化妆品成分。

Palmitoyl tetrapeptide-20(PTP20)为具保护作用的生物活性肽，旨在维护滤泡黑素细胞，常用作化妆品配料。

Tetrapeptide-21为一种生物活性肽，具备抗皱功能，常作为化妆品成分使用。

MTP 131 acetate 是一种小的线粒体靶向四肽。

Acetyl tetrapeptide-15 Acetate (Skinasensyl Acetate) 是一种用于敏感皮肤的化妆品中的合成肽，是 endomorphin-2 衍生物， 通过内啡肽样通路扩大 μ-阿片受体中的神经元兴奋性阈值范围，可用于研究由皮肤高反应性产生的炎症性和神经性疼痛。

VAMP 是一种四肽和竞争性二肽基肽酶 IV (DPP-IV) 抑制剂，其 IC50 为 1.00 μM，Kd 为 6.89 μM。VAMP 有效靶向 DPP-IV-GLP-1 轴，适用于 2 型糖尿病的研究。

Myristoyl tetrapeptide-12 直接激活SMAD2，并促使SMAD3与DNA结合。该化合物能有效促进毛发，特别是睫毛的生长。

Acetyl tetrapeptide-9 Acetate 在刺激基底膜多糖（lumican）和胶原蛋白 I 的合成中发挥作用。

BIM-46050 is a potent and specific inhibitor of human farnesyltransferase. BIM-46050 is free acidic form of BIM-46068. The IC50 values for in vitro inhibition of human brain FTase indicate that BIM-46050 and the ester form BIM-46068 are potent inhibitors of farnesyltransferase. Their potencies are in the nanomolar range and compare favorably with the compounds B581, FTI-277 and L745,631. B581 is an analog of the tetrapeptide Cys-Val-Phe-Met obtained by replacement of the amino-terminal amide bonds inhibiting processing of farnesylated proteins specifically. FTI-277 is a methyl ester of FTI-276, reported as a preferential inhibitor of FTase over GGTase I (100-fold). L745,631 is a 2-substituted piperazine reported to be a highly selective inhibitor of FTase over GGTase (2,000-fold). The selectivity of BIM-46050 and BIM-46068 for FTase over GGTase is very similar for both compounds (3,000-fold).

Tyr-W-MIF-1 是一种阿片四肽，具有阿片和抗阿片活性。Tyr-W-MIF-1 可诱导镇痛。

H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50values of 320 and 35 μM, respectively.2Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.3H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection efficiency.4 1.Park, H.S., Kim, C., and Kang, Y.K.Preferred conformations of RGDX tetrapeptides to inhibit the binding of fibrinogen to plateletsBiopolymers63(5)298-313(2002) 2.Tranqui, L., Andrieux, A., Hudry-Clergeon, G., et al.Differential structural requirements for fibrinogen binding to platelets and to endothelial cellsJ. Cell Biol.108(6)2519-2527(1989) 3.Ferris, D.M., Moodie, G.D., Dimond, P.M., et al.RGD-coated titanium implants stimulate increased bone formation in vivoBiomaterials20(23-24)2323-2331(1999) 4.Kunath, K., Merdan, T., Hegener, O., et al.Integrin targeting using RGD-PEI conjugates for in vitro gene transferJ. Gene Med.5(7)588-599(2003)

Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys.4References1. Khavinson, V.K., and Myl'nikov, S.V. Effect of epithalone on the age-specific changes in the time course of lipid peroxidation in Drosophila melanogaster. Bull. Exp. Biol. Med. 130(11), 1116-1119 (2000).2. Anisimov, V.N., Khavinson, V.K., Popovich, I.G., et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology 4(4), 193-202 (2003).3. Kossoy, G., Anisimov, V.N., Ben-Hur, H., et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H He mice. In Vivo 20(2), 253-257 (2006).4. Khavinson, V., Goncharova, N., and Lapin, B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro. Endocrinol. Lett. 22(4), 251-254 (2001). Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys.4 References1. Khavinson, V.K., and Myl'nikov, S.V. Effect of epithalone on the age-specific changes in the time course of lipid peroxidation in Drosophila melanogaster. Bull. Exp. Biol. Med. 130(11), 1116-1119 (2000).2. Anisimov, V.N., Khavinson, V.K., Popovich, I.G., et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology 4(4), 193-202 (2003).3. Kossoy, G., Anisimov, V.N., Ben-Hur, H., et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H He mice. In Vivo 20(2), 253-257 (2006).4. Khavinson, V., Goncharova, N., and Lapin, B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro. Endocrinol. Lett. 22(4), 251-254 (2001).

Ac-YVAD-CHO(L-709049)醋酸盐是一种高效、可逆、特异的四肽白介素1β转化酶(ICE)抑制剂，小鼠和人类的Ki值分别为3.0 nM和0.76 nM。它同时也能抑制caspase-1，从而抑制成熟IL-lβ的产生。

Palmitoyl Tetrapeptide-3 (Rigin) 是一种具有刺激吞噬活性的合成多肽，对应人免疫球蛋白重链的第 341-344 氨基酸序列。

Antiulcer Agent 2 是一种四肽，组成包括天冬氨酸、丙氨酸、组氨酸和赖氨酸，存在于人白蛋白N端，并在溃疡及活性氧生成中显示出潜在应用。

pGlu-His-Pro-Gly-NH2（Glp-His-Pro-Gly-NH2）为含四氨基酸肽类化合物，可激发促性腺激素、黄体生成素（LH）与促卵泡激素（FSH）释放。