tc 1

σ1 receptor ligand

AAL Toxin TC1 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125567。

TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .

PTP1B TC-PTP IN-1 是一种同时抑制PTP1B和TC-PTP的抑制剂。PTP1B TC-PTP IN-1 可用于合成PROTAC靶蛋白配体DU-14 (PTP1B TC-PTP PROTAC)。

TC-AQP1-1 是一种通过虚拟筛选鉴定的水通道蛋白 1 通道的阻断剂，并在低微摩尔浓度下抑制非洲爪蟾卵母细胞肿胀试验中通过 hAQP1 的水通量。

DU-14 (PTP1B TC-PTPPROTAC) 是一种高效且具选择性的PTP1B和TC-PTP双重PROTAC降解剂，对PTP1B和TC-PTP磷酸酶活性的 IC50分别为24.2 nM和30.1 nM。此化合物能够增强IFN-γ信号传导、促进T细胞活化，并具有抗肿瘤活性。

nicotinic α7 receptor agonist

TC 14012是一种化学肽模拟的拮抗剂，针对趋化因子(C-X-C motif)受体4（CXCR4；IC50 = 2.9 nM）和CXCR7激动剂。它能在表达CXCR7的HEK293T细胞中诱导β-arrestin招募（EC50 = 350 nM）。TC 14012可减少HIV在MT-4细胞中的细胞病理效应（EC50 = 0.4 nM），并以CXCR4依赖的方式抑制HIV在体外进入（IC50 = 19.3 nM）。它还能抑制由趋化因子(C-X-C motif)配体12（CXCL12）在MDA-MB-231乳腺癌细胞和人脐静脉内皮细胞（HUVECs）中诱导的迁移，当使用浓度范围从10到1,000 nM时。在通过左前降（LAD）冠状动脉结扎诱导的急性心肌梗死小鼠模型中，TC 14012（10 mg/kg）能减少梗死面积。

Sorafenib (Bay 43-9006) 是一种多激酶抑制剂，抑制 Raf-1、B-Raf、VEGFR2、VEGFR3、VEGFR4、PDGFRβ、FLT3、c-Kit 等 (IC50=6 22 90 15 20 20 57 58 nM)，具有口服活性。Sorafenib 具有抗肿瘤活性，可以诱导细胞自噬和凋亡，也可以激动铁死亡。

STC-15 是一种具有口服活性和有效性的 METTL3 抑制剂，具有抗癌活性，可抑制癌症生长并诱导抗癌免疫。

TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) 是一种有效的肿瘤细胞增殖抑制剂，并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间，它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。

TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).

TC13172 is an inhibitor of mixed lineage kinase domain-like protein (EC50: 2 nM for HT-29 cells).

TC-1827是一种选择性的alpha4beta2激动剂。研究发现，TC-1827能够以钟形剂量依赖方式增加早期LTP。

RTC13 是一种通读试剂，可在杜氏肌营养不良症 （DMD） 的 mdx 小鼠模型中恢复抗肌萎缩蛋白表达的能力。

RTC14, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR).References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018). STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR). References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018).

ETC-159 (ETC-1922159) 是一种具有口服活性的，有效 PORCN 抑制剂。抑制β-catenin 报告基因活性的 IC50值为2.9 nM。

NFATc1-IN-1（亦称为compound A04）是通过抑制RANKL诱导的成骨细胞形成的高效抑制剂，其IC50为1.57 μM。它通过减少RANKL诱导的NFATc1核内转移来发挥抗成骨细胞生成效应。由于其显著的特性，NFATc1-IN-1对于推进与骨质疏松症相关研究具有重要潜力[1]。

TC-1698 dihydrochloride is a selective nicotinic α7 receptor agonist that also displays weak partial agonist antagonist activity at β-subunit-containing receptors. This product is a neuroprotectant.

Ispronicline, also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potentially useful for the treatment of attention-deficit hyperactivity disorder in adults.

AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.

TC113是一种与c(RGDyK)偶联的Gemcitabine。它通过整合素αvβ3可被A549细胞内化。此外，TC113对WM266.4和A549细胞表现出显著的抗增殖效果。

Complement C1s-IN-1是一种有效的和选择性的补体C1s抑制剂，具有可口服和可穿透脑的优点，以剂量依赖的方式显著抑制人血清诱导的膜攻击复合物的形成，有效阻断经典补体途径