t-16

Antiproliferative agent-16 (Antiproliferative agent-16)是一种具有抗癌活性的吲哚酰肼-腙化合物。 Antiproliferative agent-16 对乳腺癌细胞表现出特异性 (对 MCF-7 细胞的 IC50 为 6.94 μM)。

Antitumor agent-160 (compound Ia) 是 PHENALENONE 的衍生物，并表现出抗肿瘤活性。

Antibiofilm agent-15 (Compound 17) 是一种抗菌剂，能够抑制革兰氏阳性菌和革兰氏阴性菌的生物膜形成。

Antitumor agent-163 (Compound 3) 是一种用于碳酸酐酶IX (Carbonic AnhydraseIX, CAIX) 的分子靶向光动力疗法 (Molecular-Targeted Photodynamic Therapy, MT-PDT) 的光敏剂。在 540 nm 波长光照下，该化合物通过单线态氧选择性灭活 CAIX 蛋白，而对 α-微管蛋白 (α-tubulin)、β-肌动蛋白 (β-actin) 和增殖细胞核抗原 (PCNA) 等内参蛋白无影响。它能诱导细胞膜损伤，抑制细胞活力，A549 和 U87MG 细胞的IC50分别为 0.2 和 0.05 μM。在小鼠模型中，Antitumor agent-163 展示出抗肿瘤活性。

Antitumor agent-162（compound 52a）是一种口服活性强且有效的抗肿瘤剂，具有细胞毒性。

Antitumor agent-169 (Compound B3) 是一种双重抑制剂，对PD-1/PD-L1相互作用的IC50为0.426 μM，对PARP7的IC50为2.50 nM。它与人PD-L1的亲和力Ki为20.2 nM。该化合物可以恢复T细胞功能，提升IFN-γ的分泌，同时抑制MDA-MB-231和Jurkat T细胞的活力。在小鼠模型中，Antitumor agent-169 对黑色素瘤展现出抗肿瘤作用，且具备良好的药代动力学特征。

Antitumor agent-165 (Compound 10l) 是局灶黏附激酶(FAK)的强效抑制剂。它对 CAPAN-1，PANC-1，PATU-T，SUIT-2，BxPC-3，PDAC-3 和 PANC-1 GR 细胞表现出显著的抗增殖活性，IC50 范围为 1.04-3.44 μM。

PET-16 is a HSP70 inhibitor.

ST-168 is a potent inhibitor of PI3K and MEK. ST-168 displays improved PI3K and MEK1 isoform inhibition. ST-168 demonstrated a 2.8-, 2.7-, 23-, and 2.5-fold improved inhibition toward the PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ isoforms and a 2.2-fold improvement

5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50= 0.4 μM).25α-Androst-16-en-3α-ol (0.1-1 μM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2and α2β2γ2subunit-containing GABAAreceptors.In vivo, 5α-androst-16-en-3α-ol (5-10 mg/kg) decreases immobility time in the forced swim test in mice. It increases time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at doses ranging from 30 to 50 mg/kg. 5α-Androst-16-en-3α-ol protects against seizures induced by pentylenetetrazole or electroshock in mice (ED50s = 48.9 and 21.9 mg/kg, respectively). 1.Brooksbank, B.W., Brown, R., and Gustafsson, J.A.The detection of 5α-androst-16-en-3α-ol in human male axillary sweatExperientia30(8)864-865(1974) 2.Kaminski, R.M., Marini, H., Ortinski, P.I., et al.The pheromone androstenol (5α-androst-16-en-3α-ol) is a neurosteroid positive modulator of GABAA receptorsJ. Pharmacol. Exp. Ther.317(2)694-703(2006)

Antitubercular agent-16 (Compound 5q) is a potent antitubercular agent exhibiting high efficacy against various strains of M. tuberculosis, including H37Rv, CF16, CF61, CF76, CF152, and CF161, with MIC 90 values ranging from 0.40 to 23.51 μg/mL. Notably, Antitubercular agent-16 demonstrates minimal cytotoxicity towards macrophages and pulmonary fibroblasts, further highlighting its potential as a therapeutic agent [1].

WT-161是一种HDAC6选择性有效抑制剂，IC50值为0.40 nM。

Antileishmanial agent-16 (化合物 14c) 是一种针对Leishmania的抗原虫剂，表现出针对Leishmaniamajor前鞭毛体的高效活性（IC50=0.59 µM）以及对Leishmaniamajor无鞭毛体的有效活性（IC50=0.81 µM）。此外，Antileishmanial agent-16对哺乳动物细胞（VERO 细胞）的毒性低，说明其具有较好的安全性。

Antioxidant agent-16（Product 2）展现出显著的抗氧化活性，其半抑制浓度（IC50）为6.93 ppm。

5α-Androst-16-en-3-one, a mammalian pheromone present in boar saliva, plays a crucial role in facilitating social and sexual interactions by acting as a volatile chemical cue. It is utilized to prime sows in estrus for mating or artificial insemination, underscoring its significance in reproductive behavior. Additionally, this compound is detected in human sweat and urine, where it is involved in studies concerning receptor-mediated odorant detection and the genetic foundations of anosmias, thereby broadening its scope of relevance beyond the animal kingdom.

Antitumor agent-164 (compound 60c), 作为秋水仙碱结合位点抑制剂 (CBSI)，展现出对紫杉烷敏感的 TNBC 的有效治疗作用。此化合物是 VERU-111 的先进下一代衍生物。

Antitumor agent-168(化合物21b)通过破坏肿瘤细胞的微管网络,引起G2/M细胞周期阻滞并诱导细胞凋亡.此外,该化合物能有效抑制MCF-7细胞的生长,其IC50为1.4 nM.

ent-16-Kaurene-3beta,15beta,18-triol, ent-16-kaurene-3beta,15beta-diol,abbeokutone,and helioscopinolide A possess appreciable anti-allergic activities in RBL-2H3 cells model with IC50 values ranging from 22.5 to 42.2 microM.

ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymphoma cells.

ent-16beta,17-Dihydroxy-19-kauranoic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3938，CAS号为 3301-61-9。

ent-16beta,17-dihydroxy-9(11)-kauren-19-oic acid是一种天然产物，属于菊科苍耳属，其产品编号为 TN3939，CAS号为 55483-24-4。ent-16beta,17-dihydroxy-9(11)-kauren-19-oic acid可用作对照参考。

ent-16beta,17-Isopropylidenedioxykaurane 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3940，CAS号为 58493-71-3。

EHT 1610 (EHT 5372) 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂，对 DYRK1A 和 DYRK1B 有抑制作用，的 IC50 分别为 0.36 nM 和 0.59 nM。EHT 1610 对白血病具有抑制效应，可调节细胞周期，诱导细胞凋亡。

(R)-Lansoprazole (T 168390) 是Lansoprazole 的R 型异构体。Lansoprazole 是口服有效的质子泵抑制剂，能抑制胃酸生成。Lansoprazole 是中性鞘磷脂酶(N-SMase)的抑制剂(外泌体抑制剂)，能透过血脑屏障。