AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial qualitycontrol system in H9c2 cell model established from rat embryonic myoblasts[1]. [1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the QualityControl System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.
Wilforlide A (T1) serves as a qualitycontrol standard of Tripterygium Glycosides that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. T1 has anti-inflammatory effects.
(±)-Diclofop (Standard) is the standard substance of (±)-Diclofop, and it is applicable for quantitative analysis, qualitycontrol, and related research in biochemical experiments. (±)-Diclofop is an Acetyl-CoA carboxylase (ACCase) inhibiting herbicide.
1,2,3-Trimyristoleoyl Glycerol (Standard) is the standard substance of 1,2,3-Trimyristoleoyl Glycerol, and it is applicable for quantitative analysis, qualitycontrol, and related research in biochemical experiments. 1,2,3-Trimyristoleoyl glycerol, a triacylglycerol featuring myristoleic acid at the sn-1, sn-2, and sn-3 positions, is detected in Idiazabal cheese.
1,2,3-Tri-γ-Linolenoyl Glycerol (Standard) is the standard substance of 1,2,3-Tri-γ-Linolenoyl Glycerol, and it is applicable for quantitative analysis, qualitycontrol, and related research in biochemical experiments. 1,2,3-Tri-γ-linolenoyl glycerol, a polyunsaturated triacylglycerol featuring γ-linolenoyl side chains at the C-1, C-2, and C-3 positions, occurs in multiple plant species such as blackcurrant, redcurrant, and borage.
1,2-Benzenedicarboxylic acid, diisooctyl ester (Standard) is the standard substance of 1,2-Benzenedicarboxylic acid, diisooctyl ester, and it is applicable for quantitative analysis, qualitycontrol, and related research in biochemical experiments. 1,2-Benzenedicarboxylic acid, diisooctyl ester is a natural product.
1,3-Dioleoyl Glycerol (Standard) is the standard substance of 1,3-Dioleoyl Glycerol, and it is applicable for quantitative analysis, qualitycontrol, and related research in biochemical experiments. 1,3-Dioleoyl glycerol, a diacylglycerol with oleic acid at the sn-1 and sn-3 positions, activates protein kinase C (PKC) by approximately 30% at a concentration of 50 μM.