phenylacetyl-coenzyme a

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudomonas, binding to each protein to induce derepression of various genes.2

Phenylacetyl Coenzyme A (Phenylacetyl Coenzyme A) tetrasodium 是 TetR 家族转录阻遏蛋白PaaR的效应分子。该化合物通过改变 PaaR 的构象使其与 DNA 分离并启动转录。Phenylacetyl Coenzyme A tetrasodium 有望在微生物代谢研究中发挥作用。

3,5-Dihydroxyphenylacetyl-CoA (3,5-Dihydroxyphenylacetyl-coenzyme A) 是一种酰基辅酶 A。