neurodegenerative disorder

Gedunin 是从印楝种子中提取的一种重要柠檬苦素，具有抗癌、抗病毒、抗炎和杀虫活性。它可阻断 SARS-CoV-2 病毒进入人宿主细胞，用于 COVID-19 研究。它是Hsp90抑制剂，诱导 Hsp90 依赖的蛋白降解，抑制卵巢癌细胞增殖。

Neurodegenerative Disorder-Targeting Compound 1是一种靶向 calpain 的抑制剂。

(Rac)-Neurodegenerative Disorder-Targeting Compound 1为一种针对神经退行性疾病的化合物，具有calpain抑制活性。

AA147 (ATF6-activator-147) 是小分子内质网蛋白稳态调节剂，能够选择性激活未折叠蛋白反应的 ATF6臂。

KTD-092是一种DYRK1A抑制剂，其对人源DYRK1A的IC50为22 nM。KTD-092可用于研究唐氏综合征(DS)、阿尔茨海默病(AD)、自闭症谱系障碍(ASD)、糖尿病以及其他神经退行性疾病。

KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.

C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.

C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in men with prostate cancer.

BRD3731 is a selective inhibitor of GSK3β, demonstrating an IC50 value of 15 nM for GSK3β and 215 nM for GSK3α. Due to its inhibitory properties, BRD3731 holds promise for investigating various medical conditions, including post-traumatic stress disorder (PTSD), psychiatric disorders, diabetes, and neurodegenerative disorders [1].

mHTT-IN-1 (Example 1) 为针对突变亨廷顿蛋白 (mHTT) 的高效抑制剂，该蛋白具毒性，主导遗传性常染色体显性神经退行性疾病—亨廷顿氏病 (HD) 的发生。mHTT-IN-1 能有效降低 mHTT 水平，其 EC50 值为 0.46 nM。

β-Amyloid (1-40) TFA 是阿尔茨海默症患者脑斑块中的主要蛋白片段，常用于构建阿尔茨海默症模型。

Casein kinase 1δ-IN-5 是一种高效且选择性的蛋白激酶 CK1δ 抑制剂，其 IC50 为 47 nM。在体外实验中，该化合物表现出神经保护和抗炎特性，支持其作为研究神经退行性疾病、激酶信号转导及炎症相关神经系统疾病机制的探针分子。

3β,5α,6β-Trihydroxycholanic acid, a metabolite derived from 5α,6β-dihydroxycholestanol, exhibits elevated levels in dried blood spots of patients diagnosed with Niemann-Pick disease type C, a neurodegenerative disorder characterized by the accumulation of cholesterol and sphingolipids in lysosomes.

Frataxin-IN-1 是线粒体蛋白 Frataxin 的抑制剂，其 IC 50 值为 45 μM。Frataxin-IN-1 被用于 Friedreich 共济失调（FRDA） 研究，一种与线粒体功能受损及铁-硫簇生物合成障碍相关的神经退行性疾病。

Tiliroside (Standard) 是用于 Tiliroside 相关研究及分析应用的参考标准品。Tiliroside (Tribuloside) 具有抗癌相关活性。Tiliroside 具有肝保护相关活性。Tiliroside 具有抗氧化及抗炎相关活性，并可在神经退行性疾病模型中抑制神经炎症。Tiliroside 表现出抗糖尿病相关作用，该作用至少部分与其对胃肠道碳水化合物消化及葡萄糖吸收的抑制有关。Tiliroside 与 gnaphaliin 在体外 Cu(2+) 诱导的 LDL 氧化模型中表现出与参考化合物 probucol 同数量级的抗氧化作用。Tiliroside 可通过增强与 AMP 活化蛋白激酶及过氧化物酶体增殖物激活受体 α 激活相关的 adiponectin 信号转导，从而增强脂肪酸氧化并改善肥胖诱导的代谢紊乱。因此，Tiliroside (Standard) 广泛适用于代谢、氧化应激、炎症及天然产物相关生物医学研究。

β-Amyloid (11-22) is a peptide fragment of β-Amyloid. Beta-amyloid peptide (Abeta), the primary component of amyloid plaques in the brains of Alzheimer’s patients, is believed to be the cause of Alzheimer’s Disease (AD), the most common neurodegenerative disorder.