mc-4

MC4 is a first-in-class inhibitor of ribosomal RNA synthesis with antimicrobial activity against Staphylococcus aureus.

Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this JAK3-specific inhibitor PF-06651600 led to its evaluation in several human clinical studies. JAK3 was among the first of the JAKs targeted for therapeutic intervention due to the strong validation provided by human SCID patients displaying JAK3 deficiencies.

DLIN-MC4-DMA 是一种脂质膜，是一种潜在的核酸载体。

PF-07258669 是一种选择性黑皮质素 4 受体 (MC4) 拮抗剂，可用于研究恶病质和食欲衰退。

Beta-MSH (1-22) (human) acetate (Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)) 是一种 22 肽，是一种内源性黑皮质素 4 受体 (MC4-R) 激动剂。

MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R) and can be used in the research of sexual dysfunction, obesity, and diabetes.

RMC-4550 是选择性的蛋白酪氨酸磷酸酶 2 的变构抑制剂，其IC50=0.583 nM。

UAMC-4821 是一种铁死亡抑制剂，IC50 为 5.2 nM。其功能包括清除自由基、抑制脂质过氧化，以及抑制 ML162 诱导的铁死亡，对 HT-1080 细胞具有保护作用。UAMC-4821 在小鼠体内展示了良好的药代动力学特性，口服生物利用度为 63%，并具有血脑屏障通透性。

IMC-48, as a BCL2 i-motif-interactive compound, can act by stabilizing or facilitating the folding of the i-motif.

RMC-4630 (SHP2-IN-7) 是 SHP2 的抑制剂。

RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.

RMC-4627是一种选择性的mTORC1抑制剂，可激活4EBP1并抑制肿瘤生长。

RMC-4998是一种可口服的KRASG12C突变体抑制剂，靶向KRASG12C突变体的活性状态或GTP结合状态，并且结合细胞内CYPA形成三重复合物，抑制ERK信号通路，诱导细胞凋亡，对肿瘤研究具有重要意义。

Simeprevir (TMC435) 是一种有效的 HCV NS3 4A 蛋白酶抑制剂，抑制 HCV 复制，EC50 为 7.8 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。

SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).

SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.

MC-4R Agonist 2 (实施例 1)作为MC4R激动剂，适用于肥胖、糖尿病、炎症及勃起功能障碍的研究领域。

MC4355 是 EZH2 和组蛋白脱乙酰酶 (HDAC) 的双重抑制剂。

Detorubicin is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.

Zorubicin (Rubidazon) 是Daunorubicin 的衍生物。Zorubicin 与拓扑异构酶 II 相互作用，抑制DNA 聚合酶。Zorubicin 可用于急性白血病和肉瘤的研究。

RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.

MC4343 是一种有效的EZH2和组蛋白脱乙酰酶的双重抑制剂。MC4343 具有研究癌症疾病的潜力。

Nonapeptide-1 (Melanostatine-5) acetate salt，一种多肽类激素，是 MC1R 选择性拮抗剂 (Ki: 40 nM)。 Nonapeptide-1 acetate salt 是一种竞争性的α-MSH 拮抗剂，可有效抑制黑素细胞中 α-MSH 诱导的细胞内 cAMP 和黑素体扩散 (IC50分别为 2.5 nM 和 11 nM)。 Nonapeptide-1 acetate salt 抑制黑色素合成，可用于研究皮肤色素沉着和肾上腺类固醇生成的调节、皮肤癌。

Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成，这使得它对治疗某些皮肤病很感兴趣。