c16 ceramide

C16 Ceramide (Palmitoyl Ceramide) 是一种天然小分子，通过直接选择性结合激活 p53。

C16 Ceramide (d16:1, C16:0) 是一种具有生物活性的鞘脂，能够在棕榈酰磷脂 (POPC) 双层中诱导富含棕榈酰鞘磷脂结构域的有序相和凝胶相的形成及其热稳定性。此化合物存在于人红细胞鞘磷脂中。

C16 Ceramide-1-phosphate (d18:1 16:0) ammonium salt (C16 C1P ammonium salt) 是一种酯类产品，可用于合成纳米生物制。

C16 Ceramide-d7 是 C16 Ceramide 的氘代化合物。

C16 PEG-Ceramide为一种聚乙二醇化神经酰胺，具备脂质载体传递功能，并能诱导自噬(autophagy)，在癌症研究中有应用。

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0 16:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 190249-36-6。

C16 (2'(S)-hydroxy) Ceramide (d18:1 16:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 890041-50-6。

C16 PEG750 Ceramide (C16 PEG Ceramide (MW 750)) 是一种 PEG 脂质，用于制备脂质体，适用于药物递送研究。

13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in ordered lipid domains (lipid rafts). Sphingomyelinases remove phosphorylcholine from C16 sphingomyelin to produce C16 ceramide. While ceramides commonly induce apoptosis, ceramides with different fatty acid chain lengths might direct distinct functions and, in some cases, reduce apoptosis.

C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days. |1. García-Barros, M., Coant, N., Kawamori, T., et al. Role of neutral ceramidase in colon cancer. FASEB J. 30(12), 4159-4171 (2016).

ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).

C16 dihydro Ceramide (d18:0 16:0) (Cer(d18:0 16:0)) 是合成神经酰胺的前体，诱导核周区域自噬，可用于研究细胞膜的稳定性和神经系统疾病。

C22 Ceramide (d18:1 22:0) (C22 Ceramide) 是一种从海绵Haliclona koremella 中分离出含有山嵛酸的长链神经酰胺，是一种内源性生物活性鞘脂。C22 Ceramide (d18:1 22:0) 可特异性抑制MCSR，降低离体大鼠肝线粒体和脂质体中 C16-神经酰胺通道的形成。

C16 Galactosylceramide is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid .

C16-Urea-Ceramide s a neutral ceramidase (nCDase) inhibitor. It is a bioactive ceramide.

D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1 16:0)) 是内源性Mincle配体，具免疫刺激活性。

C16 1-Deoxyceramide (m18:1 16:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 1246298-56-5。