搜索结果

Search Results for " gsh-s "

Targets Recommended: Others Ferroptosis

抑制剂 & 化合物

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T5371	L-BUTHIONINE-(S,R)-SULFOXIMINE L-Butionine sulfoximine,丁硫氨酸-亚砜亚胺	Others; Ferroptosis	Apoptosis; Others
	L-Buthionine-(S,R)-sulfoximine 是一种细胞渗透性和不可逆的 γ-谷氨酰半胱氨酸合成酶抑制剂，通过消耗 GSH 诱导细胞中的氧化应激，可降低细胞内谷胱甘肽的水平，其对黑色素瘤、乳腺卵巢癌标本的 IC50值分别为1.9 μM、8.6 μM 和29 μM。
T77650	Topoisomerase II inhibitor 14	Apoptosis; Antioxidant; Topoisomerase; NO Synthase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; oxidation-reduction
	Topoisomerase II inhibitor 14 是一种有效的拓扑异构酶 II 抑制剂，具有抗癌活性和抗氧化活性。Topoisomerase II inhibitor 14 诱导细胞凋亡，并将细胞周期阻滞在 S 期。Topoisomerase II inhibitor 14 可降低 GSH、MDA 和 NO 的量。
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T36173	L-Glutathione, oxidized (sodium salt)
	Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. GSSG is the oxidized form of GSH . It can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications. The rat...
T36073	S-Acetyl-L-glutathione
	S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases ...
T36514	QD-394
	QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin ...
T69978	Brostallicin HCl
	Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent ...
T81233	S-(p-Nitrobenzyl)glutathione
	S-(p-Nitrobenzyl)glutathione 是一种竞争性谷胱甘肽酶(GGT)抑制剂，能被大鼠肾微粒体转化成相应的半胱氨酸衍生物。该化合物用于研究谷胱甘肽酶系统中GSH的代谢及其降解过程。

化合物

L-BUTHIONINE-(S,R)-SULFOXIMINE

Cat.No: T5371

Synonym: L-Butionine sulfoximine,丁硫氨酸-亚砜亚胺

Target: Others, Ferroptosis

Topoisomerase II inhibitor 14

Cat.No: T77650

Synonym:

Target: Apoptosis, Antioxidant, Topoisomerase, NO Synthase

L-Glutathione, oxidized (sodium salt)

Cat.No: T36173

Synonym:

Target:

S-Acetyl-L-glutathione

S-(p-Nitrobenzyl)glutathione

Cat.No: T81233

Synonym:

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00979	GSH-S Protein, Human, Recombinant (His) Glutathione Synthetase,GSS	Human	E. coli
	Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the secon...
TMPH-00073	ADH2 Protein, Arabidopsis thaliana, Recombinant (His) GSH-FDH,Glutathione-dependent formaldehyde...	Arabidopsis thaliana	E. coli
	Plays a central role in formaldehyde detoxification. ADH2 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.7 kDa and the accession number is Q96533.
TMPH-00912	ADH5 Protein, Human, Recombinant (GST) Alcohol dehydrogenase class-III,A...	Human	E. coli
	ADH5 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPY-04022	BOLA1 Protein, Human, Recombinant (His) CGI-143,bolA family member 1	Human	E. coli
	BOLA1 is a mitochondrial protein that counterbalances the effect of L-buthionine-(S,R)-sulfoximine (BSO)-induced glutathione (GSH) depletion on the mitochondrial thiol redox potential. Furthermore, overexpression of BOLA1 nullifies the effect of BSO and S-nitrosocysteine on mitochondrial morphology. Conversely, knockdown of the BOLA1 gene increases the oxidation of mitochondrial thiol groups. Supporting a role of BOLA1 in controlling the mitochondrial thiol redox potential is that BOLA1 ortholog...