GSH-S

Topoisomerase II inhibitor 14 是一种有效的拓扑异构酶 II 抑制剂，具有抗癌活性和抗氧化活性。Topoisomerase II inhibitor 14 诱导细胞凋亡，并将细胞周期阻滞在 S 期。Topoisomerase II inhibitor 14 可降低 GSH、MDA 和 NO 的量。

Herbicide safener-4 (Compound I-15) 是一种除草剂安全剂，它能够增强作物对除草剂的耐受性，而不影响对杂草的除草能力。Herbicide safener-4 与 Mesosulfuron-methyl 竞争性结合在 ALS 活性位点上，提升植物内谷胱甘肽 GSH、谷胱甘肽-S-转移酶 GST、细胞色素 P450 CYP450、过氧化物酶 (POD)、超氧化物歧化酶 (SOD) 和乙酰乳酸合成酶 (ALS) 的活性。

ROS inducer 8 (Compound 11g) 是一种谷胱甘肽 (GSH) 抑制剂，能在粪肠球菌Enterococcus faecalis中诱导ROS积累，展示抗菌活性。该化合物可破坏生物膜，MIC为8 μg mL对S. aureus有效，对E. faecalis则为2 μg mL，同时具有后抗生素效应。此外，ROS inducer 8 对绵羊红细胞展现出低溶血毒性（HC50> 1280 μg mL）。

MTP 131 acetate 是一种小的线粒体靶向四肽。

S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases survival in a mouse model of HSV-1 infection.

Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. GSSG is the oxidized form of GSH . It can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications. The ratio of reduced glutathione to oxidized glutathione within cells is often used as an indicator of oxidative stress, with higher concentrations of GSSG predicting increased oxidative stress.

QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells. 1.Hu, S., Sechi, M., Singh, P.K., et al.A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen speciesJ. Med. Chem.63(17)9838-9855(2020)

L-Buthionine-(S,R)-sulfoximine 是一种 γ-谷氨酰半胱氨酸合成酶抑制剂，具有细胞渗透性、不可逆性和快速起效性。L-Buthionine-(S,R)-sulfoximine 通过消耗 GSH 诱导细胞中的氧化应激。

Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents.

Nitecapone 是一个具有口服活性的、短效的儿茶酚-O-甲基转移酶(COMT)的抑制剂。它具有胃肠道保护和抗氧化活性，能够清除活性氧和一氧化氮，防止脂质过氧化。

S-(p-Nitrobenzyl)glutathione 是一种竞争性谷胱甘肽酶(GGT)抑制剂，能被大鼠肾微粒体转化成相应的半胱氨酸衍生物。该化合物用于研究谷胱甘肽酶系统中GSH的代谢及其降解过程。

GST-FH.1 是一种 GST-FH 复合物，在谷胱甘肽 S-转移酶 (GST) 与谷胱甘肽 (GSH) 相互作用中产生假阳性结果的常见命中。GST-FH.4 抑制谷胱甘肽 S-转移酶 (GST) 活性，IC50为 0.32 μM。

GST-FH.4 是一种 GST-FH 复合物，在谷胱甘肽 S-转移酶 (GST) 和谷胱甘肽 (GSH) 的相互作用中经常出现假阳性结果。GST-FH.4 抑制谷胱甘肽 S-转移酶 (GST) 的活性，IC50为 24.38 μM。