Name: EGFRVIII Protein, Human, Recombinant (His & Avi)
Brand: TargetMol
SKU: TMPK-00691
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 343

6-8日内发货

10 μg

¥ 549

6-8日内发货

20 μg

¥ 898

5日内发货

50 μg

¥ 1,760

5日内发货

100 μg

¥ 2,960

5日内发货

200 μg

¥ 5,350

5日内发货

500 μg

¥ 11,800

5日内发货

生物活性

产品描述	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.6 kDa and the accession number is NP_001333870.1.
生物活性	Immobilized Human EGFRVIII, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-EGFRVIII Antibody, hFc Tag with the EC50 of 14.2ng/ml determined by ELISA.
研究背景	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
种属	Human
表达系统	HEK293 Cells
标签	C-His-Avi
蛋白编号	NP_001333870.1
蛋白构建	Leu25-Ser378
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	PIG61, NISBD2, mENA, LEGFR, HER1, ERBB1, ErbB, EGFR, EC 2.7.10.1, EC 2.7.10
内毒素	< 1 EU/μg by the LAL method.

化学信息

分子量	41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

EGFRVIII Protein, Human, Recombinant (His & Avi)

EGFRVIII Protein, Human, Recombinant (His & Avi)

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