Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vebicorvir (ABI-H0731) 是一种乙型肝炎病毒核心蛋白的抑制剂,有抗病毒活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 578 | 现货 | ||
5 mg | ¥ 1,330 | 现货 | ||
10 mg | ¥ 2,160 | 现货 | ||
25 mg | ¥ 3,570 | 现货 | ||
50 mg | ¥ 4,990 | 现货 | ||
100 mg | ¥ 6,880 | 现货 | ||
200 mg | ¥ 9,290 | 现货 | ||
500 mg | ¥ 13,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,370 | 现货 |
产品描述 | Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity. |
体外活性 | ABI-H0731 exhibited selective inhibition of HBV DNA replication (50% effective concentration [EC50] from 173 nM to 307 nM). Most importantly, ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM. Mechanism-of-action studies indicated that ABI-H0731 is a direct-acting antiviral that targets HBV core protein, preventing HBV pregenomic RNA (pgRNA) encapsidation and subsequent DNA replication. |
别名 | ABI-H0731 |
分子量 | 467.44 |
分子式 | C19H12F3N3O4S2 |
CAS No. | 2090064-66-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (128.36 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1393 mL | 10.6966 mL | 21.3931 mL | 53.4828 mL |
5 mM | 0.4279 mL | 2.1393 mL | 4.2786 mL | 10.6966 mL | |
10 mM | 0.2139 mL | 1.0697 mL | 2.1393 mL | 5.3483 mL | |
20 mM | 0.107 mL | 0.5348 mL | 1.0697 mL | 2.6741 mL | |
50 mM | 0.0428 mL | 0.2139 mL | 0.4279 mL | 1.0697 mL | |
100 mM | 0.0214 mL | 0.107 mL | 0.2139 mL | 0.5348 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Vebicorvir 2090064-66-5 Microbiology/Virology HBV antiviral Inhibitor inhibit ABI-H0731 Hepatitis B virus ABI-H 0731 CHB ABI-H-0731 DBT inhibitor