Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro 10-5824 dihydrochloride 是选择性的多巴胺D4 受体部分激动剂,Ki=5.2 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 283 | 现货 | ||
2 mg | ¥ 395 | 现货 | ||
5 mg | ¥ 645 | 现货 | ||
10 mg | ¥ 927 | 现货 | ||
25 mg | ¥ 1,670 | 现货 | ||
50 mg | ¥ 2,490 | 现货 | ||
100 mg | ¥ 3,670 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 726 | 现货 |
产品描述 | Ro 10-5824 dihydrochloride is a selective agonist of dopamine D4 receptor partial, (Ki of 5.2 nM). |
靶点活性 | dopamine D4 receptor:5.2 nM (ki) |
体外活性 | RO-10-5824 shows high affinity binding(Ki=5.2±0.9 nM (n=3)), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding (EC50 : 205±67 nM) (n=7) and maximal induction at 36±4% above basal level[2]. |
体内活性 | The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice[2]. |
分子量 | 353.29 |
分子式 | C17H22Cl2N4 |
CAS No. | 189744-94-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 60 mg/mL (169.83 mM)
DMSO: 8.33 mg/mL (23.58 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.8305 mL | 14.1527 mL | 28.3054 mL | 70.7634 mL |
5 mM | 0.5661 mL | 2.8305 mL | 5.6611 mL | 14.1527 mL | |
10 mM | 0.2831 mL | 1.4153 mL | 2.8305 mL | 7.0763 mL | |
20 mM | 0.1415 mL | 0.7076 mL | 1.4153 mL | 3.5382 mL | |
H2O | 50 mM | 0.0566 mL | 0.2831 mL | 0.5661 mL | 1.4153 mL |
100 mM | 0.0283 mL | 0.1415 mL | 0.2831 mL | 0.7076 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ro 10-5824 dihydrochloride 189744-94-3 GPCR/G Protein Neuroscience Dopamine Receptor Inhibitor inhibit Ro 105824 dihydrochloride Ro 10-5824 Dihydrochloride Ro 10-5824 Ro 10 5824 dihydrochloride inhibitor