keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RS 42358-197 (RS 25259-007) 是一种竞争性 5-HT3 受体拮抗剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,880 | 现货 | ||
2 mg | ¥ 2,830 | 现货 | ||
5 mg | ¥ 4,360 | 现货 | ||
10 mg | ¥ 6,530 | 现货 | ||
25 mg | ¥ 9,790 | 现货 | ||
50 mg | ¥ 13,200 | 现货 | ||
100 mg | ¥ 17,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,190 | 现货 |
产品描述 | RS 42358-197 (RS 25259-007) is a competitive 5-HT3 receptor antagonist. |
体外活性 | RS 42358-197 acts against 5-HT-induced contractions in the guinea pig ileum (low-potency phase), yielding a pA2 estimate of 8.1[1]. |
体内活性 | In anesthetized rats. RS 42358-197, administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 micrograms/kg; i.v., 5.7 micrograms/kg; i.d., and 11.6 micrograms/chamber, respectively). In this regard, when administered intraduodenally, RS 42358-197 was more potent and exhibited a longer duration of action than either ondansetron or granisetron. In dogs, RS 42358-197, administered either intravenously or orally, dose-dependently inhibited the emesis induced by cisplatin, actinomycin and cyclophosphamide, but not that induced by apomorphine. When tested at maximally effective doses against cisplatin-induced emesis in dogs, RS 42358-197 had a longer duration of antiemetic activity (> 6 h) than ondansetron (2 h). RS 42358-197, administered orally, also afforded protection against cisplatin-induced emesis in ferrets. At doses that showed marked anti-emetic activity in dogs (10-100 micrograms/kg; i.v. and 100-1000 micrograms/kg; i.d.), RS 42358-197 did not produce any hemodynamic changes[1]. |
别名 | RS-42358-197, RS42358-197, RS 25259-007 |
分子量 | 330.85 |
分子式 | C19H23ClN2O |
CAS No. | 135729-55-4 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (33.25 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0225 mL | 15.1126 mL | 30.2252 mL | 75.5629 mL |
5 mM | 0.6045 mL | 3.0225 mL | 6.045 mL | 15.1126 mL | |
10 mM | 0.3023 mL | 1.5113 mL | 3.0225 mL | 7.5563 mL | |
20 mM | 0.1511 mL | 0.7556 mL | 1.5113 mL | 3.7781 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
RS 42358-197 135729-55-4 GPCR/G Protein Neuroscience 5-HT Receptor RS-42358-197 RS42358-197 RS 25259-007 Inhibitor inhibitor inhibit