Powder: -20°C for 3 years | In solvent: -80°C for 1 year
E-5324 is potent cholesterol acyltransferase (ACAT) inhibitor (IC50s: 44 to 190 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 13,900 | 8-10周 | ||
50 mg | ¥ 18,300 | 8-10周 | ||
100 mg | ¥ 23,500 | 8-10周 |
产品描述 | E-5324 is potent cholesterol acyltransferase (ACAT) inhibitor (IC50s: 44 to 190 nM). |
靶点活性 | ACAT:44 to 190 nM |
体外活性 | E-5324 inhibits the incorporation of [3H]oleate into cholesteryl [3H]oleate in a concentration-dependent manner (IC50: 0.44 μM) and it also inhibits [3H]cholesteryl ester synthesis (IC50: 0.41 μM). E-5324 displays no effect on triglyceride synthesis up to 10 μM and it also has no effect on bovine pancreatic cholesterol esterase or lecithin: cholesterol acyltransferase (LCAT) up to 10 μM [1]. |
体内活性 | E-5324 treatment significantly decreases the wet weight and protein content. The high dose of E-5324 (0.1%) obviously decreases the surface involvement by 34% and 54% in the aortic arch and thoracic aorta, respectively. In the aortic arch, the high dose of E-5324 (0.1%) obviously reduces both cholesteryl ester and total cholesterol by 60% and 59%, respectively. The high dose of E-5324 (0.1%) markedly decreases the ACAT activities in the aortic arch and thoracic aorta by 35% and 44%, respectively. The areas under the cholesterol-time curves for duration of this study (AUC) for control, E-5324 0.02% and E-5324 0.1% are 104985±4411, 106096±4476 and 105231±4 348 mg×day/dL, respectively [2]. |
分子量 | 434.57 |
分子式 | C26H34N4O2 |
CAS No. | 141799-76-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
E-5324 141799-76-0 Others E5324 E 5324 Inhibitor inhibitor inhibit