store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Caspofungin Acetate (MK 0991) 是一种抗真菌药,能够非竞争性地抑制 1,3-β-D 葡聚糖合酶的合成。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 197 | 现货 | ||
5 mg | ¥ 427 | 现货 | ||
10 mg | ¥ 773 | 现货 | ||
25 mg | ¥ 1,430 | 现货 | ||
50 mg | ¥ 2,190 | 现货 | ||
100 mg | ¥ 3,280 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 987 | 现货 |
产品描述 | Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. This agent is active against Aspergillus and Candida species. |
体外活性 | Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Prior studies have shown in vitro activity of caspofungin acetate using the reference methods, broth microdilution or macrodilution, for antifungal susceptibility testing of Candida species established by the National Committee for Clinical Laboratory Standards 1997 guidelines against a variety of Candida species including Candida krusei. Although caspofungin acetate is only Food and Drug Administration-approved for the treatment of aspergillosis, there is information showing that many Candida species are susceptible. The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate are as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0) |
体内活性 | Mice injected with caspofungin at vitreal concentrations from 0.41 to 4.1 μM cause no significant alterations in their ERG waveforms and their retinas have no detectable morphologic changes or loss of cells. At the vitreal concentration of 41 μM, caspofungin reduces the amplitudes of the a-waves, b-waves, and scotopic threshold responses of the ERG and also produces a decrease in the number of cells in the ganglion cell layer[4]. Caspofungin (8 mg/kg) or amphotericin B at 1 mg/kg given i.p. once daily for 7 days beginning at 30 h after infection resulted in 100% survival through day 28 relative to vehicle control treatment, which results in 100% mortality by day 11 after infectious challenge. Caspofungin reduces recovery of viable Candida from kidney and brain tissues compared to vehicle control treatment on day 5, when control burden peaked. Caspofungin-treated mice dosed with 2 mg/kg or greater have significantly lower brain burden than amphotericin-B-treated mice at day 5. Amphotericin B and caspofungin treatment reduce kidney fungal burden by 1.7 log CFU/g and 2.46 to 3.64 log CFU/g, respectively[5]. |
别名 | 醋酸卡泊芬净, L 743873, Cancidas, MK 0991, L 743872 |
分子量 | 1213.42 |
分子式 | C56H96N10O19 |
CAS No. | 179463-17-3 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.3 mg/mL (68.65 mM)
H2O: 100 mg/mL (82.41 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 0.8241 mL | 4.1206 mL | 8.2412 mL | 20.6029 mL |
5 mM | 0.1648 mL | 0.8241 mL | 1.6482 mL | 4.1206 mL | |
10 mM | 0.0824 mL | 0.4121 mL | 0.8241 mL | 2.0603 mL | |
20 mM | 0.0412 mL | 0.206 mL | 0.4121 mL | 1.0301 mL | |
50 mM | 0.0165 mL | 0.0824 mL | 0.1648 mL | 0.4121 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Caspofungin Acetate 179463-17-3 Microbiology/Virology Antibiotic Antifungal fungal cell wall inhibit MK-0991 diacetate L743873 MK-0991 Fungal Inhibitor L-743872 醋酸卡泊芬净 antifungal L 743873 Caspofungin diacetate MK0991 L-743873 Cancidas L-743872 diacetate MK 0991 L743872 L 743872 inhibitor