Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor. It is a macrolide antibiotic isolated from Streptomyces rochei.
产品描述 | Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor. It is a macrolide antibiotic isolated from Streptomyces rochei. |
靶点活性 | CDC28-Cln2:24 μM |
体外活性 | Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast (IC50: 24 μM) [2]. Borrelidin is a potent angiogenesis inhibitor (IC50: 0.8 nM) and induces apoptosis of the tube-forming cells. Borrelidin has strong antimalarial activities (IC50s: 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum) [3]. |
别名 | Treponemycin |
分子量 | 489.64 |
分子式 | C28H43NO6 |
CAS No. | 7184-60-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 100 mg/mL (204.23 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol | 1 mM | 2.0423 mL | 10.2116 mL | 20.4232 mL | 51.0579 mL |
5 mM | 0.4085 mL | 2.0423 mL | 4.0846 mL | 10.2116 mL | |
10 mM | 0.2042 mL | 1.0212 mL | 2.0423 mL | 5.1058 mL | |
20 mM | 0.1021 mL | 0.5106 mL | 1.0212 mL | 2.5529 mL | |
50 mM | 0.0408 mL | 0.2042 mL | 0.4085 mL | 1.0212 mL | |
100 mM | 0.0204 mL | 0.1021 mL | 0.2042 mL | 0.5106 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Borrelidin 7184-60-3 Others Treponemycin Inhibitor inhibitor inhibit