Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1-Methylguanidine hydrochloride 是内源性代谢产物的一种。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 417 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 462 | 现货 |
产品描述 | Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibits anti-inflammatory effects. Methylguanidine is synthesized from creatinine concomitant with the synthesis of hydrogen peroxide from endogenous substrates in peroxisomes. Recent evidence suggests that methylguanidine significantly inhibits iNOS activity and TNF- release. This means that methylguandine can attenuate the degree of inflammation and tissue damage associated with endotoxic shock. |
分子量 | 109.56 |
分子式 | C2H8ClN3 |
CAS No. | 21770-81-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (502.01 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 9.1274 mL | 45.6371 mL | 91.2742 mL | 228.1855 mL |
5 mM | 1.8255 mL | 9.1274 mL | 18.2548 mL | 45.6371 mL | |
10 mM | 0.9127 mL | 4.5637 mL | 9.1274 mL | 22.8185 mL | |
20 mM | 0.4564 mL | 2.2819 mL | 4.5637 mL | 11.4093 mL | |
50 mM | 0.1825 mL | 0.9127 mL | 1.8255 mL | 4.5637 mL | |
100 mM | 0.0913 mL | 0.4564 mL | 0.9127 mL | 2.2819 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
1-Methylguanidine hydrochloride 21770-81-0 Metabolism Others Endogenous Metabolite 1 Methylguanidine hydrochloride 1-Methylguanidine inhibit 1-Methylguanidine Hydrochloride 1Methylguanidine hydrochloride Inhibitor inhibitor