MT Receptor

Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. Three types of melatonin receptors have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. The receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin has been found to be a key player in the synchrony of biological clocks. Melatonin secretion by the pineal gland has circadian rhythmicity regulated by the suprachiasmatic nucleus (SCN) found in the brain. The SCN functions as the timing regulator for melatonin; melatonin then follows a feedback loop to decrease SCN neuronal firing. The receptors MT1 and MT2 control this process. Melatonin receptors are found throughout the body in places such as the brain, the retina of the eye, the cardiovascular system, the liver and gallbladder, the colon, the skin, the kidneys, and many others.

Cat. No.	Product Name	CAS No.	Purity
T16834	S26131 化合物S26131	296280-56-3	98%
S26131 是一种选择性的褪黑激素配体 MT1 和 MT2 拮抗剂，对 MT1 和 MT2 的Ki值分别为 0.5 和 112 nM。
T1463	Ramelteon 雷美替胺	196597-26-9	99.94%
Ramelteon 是强效高选择性和可口服的MT1/MT2激动剂，Ki值分别为 14 和 112 pM，有用于失眠症的研究潜力。
T3495	Tasimelteon 他司美琼	609799-22-6	99.93%
Tasimelteon 是一种褪黑激素受体激动剂，用于治疗盲人的非 24 小时睡眠-觉醒障碍。
T2O2728	Glycine 甘氨酸	56-40-6	99.54%
Glycine 是中枢神经系统的抑制性神经递质，也是谷氨酸的联合激动剂，有促进谷氨酸能NMDA受体兴奋的潜力。它主要存在于明胶和丝素蛋白中，并在治疗上用作营养物质。
T15795	Luzindole N-乙酰-2-苄基色胺	117946-91-5	98.96%
Luzindole 是一种选择性褪黑素受体拮抗剂，可抑制实验性自身免疫性脑脊髓炎，有抗抑郁样活性。它优先靶向 MT2 (Mel1b)，对于人 MT2 和 MT1 的Ki值分别为 10.2 和 158 nM。
T9193	ACH-000143 化合物ACH-000143	2225836-30-4	98.05%
ACH-000143 是一种可口服的褪黑素受体激动剂，对 MT1 和 MT2 的EC50值分别为0.06 和0.32 nM。
T14042	4-P-PDOT 化合物4-P-PDOT	134865-74-0	98%
4-P-PDOT 是一种选择性和亲和性的褪黑激素受体拮抗剂，可显著抵消褪黑激素介导的抗氧化作用。它对MT2的选择性是 MT1 的 300 倍以上。

Cat. No.

Product Name

CAS No.

Purity

Chemical Structure

T16834

S26131

化合物S26131

296280-56-3

98%