vstm 3

T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.

TIGIT Protein, Human, Recombinant (aa 22-141, His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 14.51 kDa and the accession number is NP_776160.2.

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: BLI、ELISA

TIGIT Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.2 kDa and the accession number is NP_001139797.1.

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

TIGIT Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 16.01 kDa and the accession number is NP_001139797.1.

Expression system: HEK293 Cells
Length: 22-141, Extracellular Domain
Activity: ELISA

TIGIT Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.8 kDa and the accession number is P86176.

TIGIT Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 39.93 kDa and the accession number is NP_001139797.1.

Expression system: HEK293 Cells
Length: 22-141, Extracellular Domain
Activity: SPR、BLI、Octet RED、ELISA

TIGIT Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 Cells+J15. The accession number is Q495A1.