type-2 angiotensin ii receptor

Apelin-13 是存在于中枢和外周神经系统由13个氨基酸组成的多肽序列，是 G 蛋白偶联受体angiotensin II protein J (APJ) 的内源性配体，对 APJ 的 EC50 值为 0.37 nM。Apelin-13 具有扩张血管和降压活性，可用于研究 2 型糖尿病综合征。

WL 19 是一种针对血管紧张素 II 类型 2 受体的拮抗剂。

Olodanrigan sodium （EMA-401 sodium）是一种具有口服活性和选择性的血管紧张素 Ⅱ 类型 2 受体 (AT2R) 拮抗剂，可用于研究神经系统疾病。

12(S)-HETE 是花生四烯酸的12-脂氧合酶代谢产物，对癌细胞增殖具有促有丝分裂作用，可增强血管紧张素 II 诱导的 BLT2 收缩（白三烯 B4小鼠动脉中 2 型受体）和 TP （血栓素受体） 介导的机制。12(S)-HETE促进动脉内皮细胞中超氧化物和异血栓素样代谢物的产生。

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.

L-163491 is a drug which acts as a partial agonist of angiotensin II receptor type 1, and with lower affinity as an agonist of angiotensin II receptor type 2, mimicking the action of angiotensin II. Its practical applications to date have been limited to scientific research into the function of the angiotensin receptor system, but it has been suggested as a potential therapeutic agent for the treatment of inflammation of the lungs associated with certain viral diseases such as COVID-19.

Angiotensin II human TFA 是肾素-血管紧张素系统中的强效血管收缩剂，通过与 AT1R 和 AT2R 受体作用调节血压，可激活交感神经、促进醛固酮合成和肾功能，诱导血管平滑肌细胞增殖及成纤维细胞中 I 型和 III 型胶原合成，导致血管和心肌增厚、纤维化，并诱导凋亡及促进毛细血管生成，可用于构建心脏肥大、高血压和腹主动脉瘤模型。

Tasosartan (WAY-ANA 756) 是长效血管紧张素 II 受体拮抗剂。