pyruvate oxidation

Glymidine sodium 是口服有活性的抗糖尿病药物，也是肝脂肪分解的抑制剂。它通过抑制葡萄糖的形成，也对由于内源性脂质动员抑制而导致的丙酮酸氧化升高具有抑制作用。

(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸，是水果酸甜味的来源，常用作食品添加剂。

Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells. It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.

D-Lactate dehydrogenase(D-LDH)为一种氧化还原酶，以NAD+或NADP+作为受体，特异性作用于供体的CH-OH基团，催化D-乳酸氧化成丙酮酸。该酶主要分布于细菌和真菌中，是生化研究中常用的酶。