nf1

1-Naphthyl phosphate potassium salt 是非特异性磷酸酶 (phosphatase) 抑制剂，能够降低剪接校正作用。

GNF179 Metabolite, the derivative of GNF179—an optimized 8,8-dimethyl IP analog—demonstrates significant potency (4.8 nM against the multidrug-resistant W2 strain) alongside in vitro metabolic stability and in vivo oral bioavailability.

GNF179 是8,8-二甲基 IP 类似物。 它表现出对多药耐药菌株 W2 的效力，具有良好的体外代谢稳定性和体内口服生物相容性。

NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35). The IC50s are 463 nM, 1811 µM, 170 µM for P2Y

P2X3 antagonist

Schidigerasaponin F1 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125155，CAS号为 266998-42-9。

GDCNF-11, 一种HIM-PROTACGPX4降解剂，依赖于HSP90伴侣复合物的作用，促使GPX4发生泛素化并加速其降解。此作用能够有效降低GPX4的内源性水平，进而在HT-1080细胞中诱导铁死亡(ferroptosis)。其DC50值达到0.08 μM。

17-TFM-PGF1α (Compound 8) 为一种饱和前列腺素类似物。此化合物对人前列腺素 F 受体 (hFP receptor) 表现出较强的亲和性和受体选择性，其EC50为 85 nM。

NF-1819 是一种高效、选择性的不可逆 MGL (β-内酰胺基单酰甘油脂肪酶)抑制剂。NF-1819 在体内多发性硬化症模型中缓解疾病症状，在体内急性炎性疼痛模型中表现出镇痛作用。NF-1819 具有较高的膜通透性和血脑屏障通透性。

GNF-1331 is a potent, selective, and orally bioavailable porcupine inhibitor (IC50 = 12 nM). Blocking abnormal Wnt signaling is an attractive treatment for a variety of cancers.

13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach. The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α.

8-iso Prostaglandin F1α（8-异前列腺素 F1α）是一种由花生四烯酸产生的异前列腺素，能引起浓度依赖性的的血管收缩效应，包括肺动脉（PA）、肺静脉（PV）和肠系膜动脉（MA），通过TXA2R、酪氨酸激酶和Rho激酶的激活。

8-iso Prostaglandin F1β（8-异前列腺素 F1β）是一种由花生四烯酸产生的异前列腺素，能引起浓度依赖性的的血管收缩效应，包括肺动脉（PA）、肺静脉（PV）和肠系膜动脉（MA），通过TXA2R、酪氨酸激酶和Rho激酶的激活。

6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.

11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs.

11-deoxy PGF1β is a synthetic analog of PGF1β. In contrast to PGF2α and PGF1α, 11-deoxy PGF1β exhibits vasodepressor and bronchodilator activities in guinea pigs at a dose of 500 μg kg.

Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3]

15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.

2,3-dinor-8-iso Prostaglandin F1α（2,3-dinor-8-iso PGF1α）是一种异前列腺素和花生四烯酸的活性代谢物，也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩（EC50s分别为12.8和18.5 nM），但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时，它能增加孤立的猪大脑切片中的血栓素B2（TXB2）水平，这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体（nAChR）拮抗剂α-conotoxin来逆转。

Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α), a cyclooxygenase (COX) metabolite produced from eicosapentaenoic acid (EPA) in a variety of tissues including seminal vesicles, lungs, polymorphonuclear leukocytes, and ocular tissues, alongside other 3-series COX products from EPA such as PGF3α, PGE3, and thromboxane B3, is potentially linked to a lower occurrence of glaucoma in individuals consuming a marine-rich (EPA-rich) diet.

PGF1β, a biochemical compound, functions as a pivotal mediator in inflammatory processes and plays an integral role in uterine contractions. It exhibits significant regulatory effects on platelet aggregation and vasodilation, demonstrating its critical importance in cardiovascular health. Additionally, PGF1β contributes to the regulation of kidney function and electrolyte balance, illustrating its widespread impact across various physiological systems.

INF 195 是一种炎性小体 NLRP3 抑制剂，抑制 NLRP3 驱动的巨噬细胞焦亡 和 IL-1β 释放。INF 195 可减轻异丙肾上腺素诱导的 H9c2 大鼠成肌细胞肥大，可用于研究心肌缺血和心肌梗死。

αs1-CN f(143–149) 是一种酪蛋白衍生的肽序列,具备口服活性.该化合物显示出血管紧张素转换酶 (ACE) 的抑制效果(IC50=6.58 μM),并具有抗高血压活性.

TNF-α (10-36), human (TFA) is a peptide of human TNF-α.