leukotriene a4

SC-57461A 是一种口服有活力的非肽类白三烯 A4 (LTA4) 水解酶选择性抑制剂，它能够抑制重组人 (IC50: 2.5 nM) 、小鼠 (IC50: 3 nM) 和小鼠LTA4水解酶 (IC50: 23 nM) 。

白三烯A4甲酯可在大鼠肝脏中主要碱性胞质谷胱甘肽转移酶的催化下转化为白三烯C4单甲酯，可用于代谢相关研究。

Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N) APN 和leukotriene A4 hydrolase 抑制剂，可研究癌症。

Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N) APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。

DG051 是有效的白三烯 A4 水解酶抑制剂，IC50=47 nM。

5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM.

Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N) APN 和 leukotriene A4 hydrolase 抑制剂，经常用于研究癌症。

Acebilustat (CTX-4430) 是一种具有口服活性的白三烯 A4 水解酶抑制剂，可用于炎症研究。

Compound (S)-2 (LTA4H-IN-2) 为具有口服活性的白三烯A4水解酶抑制剂，显示出极低的IC50值，小于3 nM。

5(S)-Hydroperoxyeicosatetraenoic acid (5(S)-HpETE) is a monohydroperoxy polyunsaturated fatty acid (PUFA) generated by the enzymatic conversion of arachidonic acid via 5-lipoxygenase (5-LO). Subsequently, 5(S)-HpETE undergoes metabolism to form leukotriene A4 (LTA4), which serves as a pivotal intermediate in the synthesis of leukotrienes (LTs).

Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM). 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.

DG-051 is a novel leukotriene A4 (LTA4H) hydrolase inhibitor of leukotriene B4 biosynthesis.

Tosedostat (CHR-2797) 是一种具有口服活性的氨基肽酶(aminopeptidase) 抑制剂，对多种肿瘤细胞系均具有抗增殖作用。

LYS006 hydrochloride (1799681-85-8 Free base) 是一种有效的白三烯 A4 水解酶 LTA4H 抑制剂,IC50 值为 2 nM，可用于研究炎症和自身免疫性疾病，包括溃疡性结肠炎和NASH。

LTA4H-IN-1 是一种有效的白三烯 A4 水解酶LTA4H 抑制剂，IC50值为 2 nM，可用于炎症和自身免疫性疾病研究。

Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 μM.[2] LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.[2],[3],[4]

4-MDM (4-Methoxydiphenylmethane) 是一种能口服生效的选择性抗炎化合物，通过增强白三烯 A4 水解酶 (LTA4H) 的氨肽酶活性来实现作用。其通过促进LTA4H对脯氨酸-甘氨酸-脯氨酸的降解以减少肺内中性粒细胞的募集，减轻炎症反应，同时不影响LTA4H的环氧水解酶活性。4-MDM 可用于研究与肺部疾病相关的问题。

LYS006 hydrochloride 是一种高效的LTA4H（白三烯 A4 水解酶）抑制剂，具有IC50值为2 nM。LYS006 hydrochloride 适用于炎症及自身免疫性疾病的研究。有关详细信息，请参阅专利文献 WO2015092740A1 中的化合物29。

SC-22716 是一种具有口服活性的白三烯 A4（LTA4）水解酶抑制剂。SC-22716 具有潜在的抗炎活性，可用于研究炎症性肠病和银屑病。

JNJ-26993135 is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor.