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32

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40857	Calcium ionophore II Calcium ionophore II,N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide	Others	Others
	Calcium ionophore II (N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide) 是一种亲脂性离子载体，可用于制备钙离子选择性电极。
T3956	Sodium ionophore III ETH2120	Sodium Channel	Membrane transporter/Ion channel
	Sodium ionophore III (ETH2120) 是一种Na+载体，适用于测定血液、血浆、血清中的钠活性。
T21663	Calcium Ionophore I
	Calcium Ionophore I 在生命科学相关研究中具有广泛的应用。
T6170	Elesclomol 伊利司莫,STA-4783	Apoptosis; HSP; Reactive Oxygen Species	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	Elesclomol (STA-4783) 是一种氧化应激诱导剂，也是一种高度亲脂性的铜离子载体。Elesclomol 可以诱导肿瘤细胞凋亡，用于铜死亡相关研究。Elesclomol 还可以抑制 FDX1 介导的 Fe-S 簇生物合成。
T82727	Chromoionophore XIII SNARF-DE
	Chromoionophore XIII (SNARF-DE)是一种可用红光激发的pH传感器。其功能质使指示剂分子具有亲脂性而不溶于水，并且能抑制该染料在极性环境下发生内酯化反应。
T12593	Pyrithione 1-hydroxyl-1H-pyridine-2-thione,吡啶硫酮	Others	Others
	Pyrithione (1-hydroxyl-1H-pyridine-2-thione) 是一种锌离子载体，过渡金属配合物，可引起哺乳动物细胞内锌水平的升高，有杀菌和抗真菌作用。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T26474	A28086B A 28086B,A-28086B
	A28086B is an ionophore antibiotic.
T34992	UK 58852 UK58852
	UK 58852 is a polyether ionophore.
T32538	Laidlomycin butyrate
	Laidlomycin butyrate is a ionophore with enhanced intraruminal activity.
T31638	Enniatin C
	Enniatin C is an ionophore that can bind ammonium.
T27504	GV-196771
	GV-196771 selectively antagonize the glycine-binding site of the NMDA ionophore.
T26421	A 55453 A55453,A-55453
	A 55453 is a radiated ionophore used as a reversibl, high-affinity alpha 1-adrenergic receptor probe.
T30147	AS 701 AS-701,AS701
	AS-701 is a Li+ selective ionophore in the therapy of manic-depressive illness.
T16323	Nigericin	Others	Others
	Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin can be an NLRP3 activator that causes the release of IL-1β as a NALP3-dependent manner. N
T10137	4-Bromo A23187 4-Bromo A23187	Others	Others
	4-Bromo A23187 is a halogenated analog of the calcium ionophore A-23187. 4-Bromo A23187 is a calcium modulator and induces apoptosis in different cells.
T34492	Salinazid Nilazid,Salicylaldehyde isonicotinoyl hydrazone,Salizid,Salizide,Nupasal,SIH1	Others	Others
	Salinazid (Salicylaldehyde isonicotinoyl hydrazone) 是一种有效的抗结核药。
T21681	AACOCF3 Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane	Phospholipase	Metabolism
	AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Moreover, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. Given its diverse applications, AACOCF3 ...
T37284	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes.
T37650	5(S),15(S)-DiHETE
	5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.
T37124	1,3-Dipalmitoleoyl-rac-glycerol
	1,3-Dipalmitoleoyl-rac-glycerol is a diacylglycerol with palmitoleic acid at the sn-1 and sn-3 positions. It selectively inhibits α-glucosidase from S. cerevisiae over rat enzyme (IC50s = 4.45 and 9,326.5 μM, respectively). 1,3-Dipalmitoleoyl-rac-glycerol has been used in the formation of lipid bilayers to study the effects of membrane composition and the ionophore valinomycin on membrane potential.
T37649	5(S),12(S)-DiHETE
	5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotrie...
T35541	Lipoxygenin
	Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin...
T37492	11-trans Leukotriene C4 11-trans Leukotriene C4
	11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ...
T37331	Pyrrophenone
	The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as py...
T35731	Deethylindanomycin
	Deethylindanomycin is a polyether antibiotic that has been found in S. setonii. It is active against a variety of Gram-positive bacteria, including various strains of S. aureus and Streptococcus, as well as one strain of S. pneumoniae (MICs = 4, 4, and 2 μg/ml, respectively). It is also active against coccidia in vitro, inhibiting E. tenella development, but is inactive against E. tenella infection in chicks when administered at a dose of 200 μg/g in the diet. Deethylindanomycin acts as an ionop...
T37052	Tetranactin
	Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-depen...
T35509	(±)14-HDHA
	(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA. 14(S)-HDoHE is also produced by salmon gills upon stimulation with calcium ionophore. 14(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 70, 3...
T37606	Resolvin D5 7(S),17(S)-diHDHA
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D5 (RvD5) is a DHA-derived resolvin generated by a double dioxygenation mechanism.[3] RvD5 has been identified in media from ionophore-stimulated trout brain cells, in human synovial fluid from patients with rheumatoid arthritis, and in...
T75656	Calcimycin hemimagnesium
	Calcimycin (A-23187) hemimagnesium，一种具有抗生素功能的独特二价阳离子离子载体（例如钙离子和镁离子），通过提高细胞内钙浓度而诱导Ca2+依赖性细胞死亡。该化合物还能抑制革兰氏阳性细菌和部分真菌生长，同时抑制ATP酶活性并解耦哺乳动物细胞的氧化磷酸化（OXPHOS），触发细胞凋亡（apoptosis）。
T14205	AM679	Others	Others
	AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. IC50 value: 2.2 nM/0.6 nM/154 nM(FLAP binding/hLA/hWB) [1] AM679 showed an improved CYP inhibition profile (IC50 3A4 = 16.7 lM, 2C9 =
T83773	Prostaglandin E2 Inhibitor 3 PGE2 Inhibitor 3
	Prostaglandin E2抑制剂3是一种microsomal prostaglandin E合酶-1 (mPGES-1; IC50 = 0.2 µM)的抑制剂，相较于COX-1、COX-2、5-lipoxygenase (5-LO)和soluble epoxide hydrolase (sEH)，在10 µM的无细胞试验中表现出对mPGES-1的选择性。在10 µM和1 µM的浓度下，该抑制剂能抑制A549细胞中IL-1β诱导的PGE2生成以及在J774A.1巨噬细胞中，LPS诱导的IL-6和PGE2生成。同时，它还能抑制由钙离子载体A23187单独或结合花生四烯酸和A23187诱导的5-LO产物形成，包括白三烯B4 (LTB4) 和5-H(p)ETE（IC50s分别为4.9和5.2 µM）。在体内，10 mg/kg剂量的Prostaglandin E2抑制剂3能防止在zymosan诱导的小鼠腹膜炎模型中白细胞渗入腹腔液中。

化合物

Calcium ionophore II

Cat.No: T40857

Synonym: Calcium ionophore II,N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide

Target: Others

Sodium ionophore III

Cat.No: T3956

Synonym: ETH2120

Target: Sodium Channel

Calcium Ionophore I

Cat.No: T21663

Cat.No: T6170

Synonym: 伊利司莫,STA-4783

Target: Apoptosis, HSP, Reactive Oxygen Species

Chromoionophore XIII

Cat.No: T82727

Synonym: SNARF-DE

Cat.No: T12593

Synonym: 1-hydroxyl-1H-pyridine-2-thione,吡啶硫酮

Target: Others

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

Cat.No: T26474

Synonym: A 28086B,A-28086B

Cat.No: T34992

Synonym: UK58852

Laidlomycin butyrate

Cat.No: T32538

Cat.No: T31638

Cat.No: T27504

Cat.No: T26421

Synonym: A55453,A-55453

Cat.No: T30147

Synonym: AS-701,AS701

Cat.No: T16323

Target: Others

Cat.No: T10137

Synonym: 4-Bromo A23187

Target: Others

Cat.No: T34492

Synonym: Nilazid,Salicylaldehyde isonicotinoyl hydrazone,Salizid,Salizide,Nupasal,SIH1

Target: Others

Cat.No: T21681

Synonym: Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane

Target: Phospholipase

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

Cat.No: T37284

5(S),15(S)-DiHETE

Cat.No: T37650

1,3-Dipalmitoleoyl-rac-glycerol

Cat.No: T37124

5(S),12(S)-DiHETE

Cat.No: T37649

Cat.No: T35541

11-trans Leukotriene C4

Cat.No: T37492

Synonym: 11-trans Leukotriene C4

Cat.No: T37331

Deethylindanomycin

Cat.No: T35731

Cat.No: T37052

Cat.No: T35509

Cat.No: T37606

Synonym: 7(S),17(S)-diHDHA

Calcimycin hemimagnesium

Cat.No: T75656

Cat.No: T14205

Target: Others

Prostaglandin E2 Inhibitor 3

Cat.No: T83773

Synonym: PGE2 Inhibitor 3

Cat. No.	Product Name	Target	Signaling Pathways
T15717	Lasalocid Lasalocid-A,Antibiotic X-537A,Ionophore X-537A	Antibacterial	Microbiology/Virology
	Lasalocid (Lasalocid-A) 是一种由链霉菌产生的离子载体抗生素，具有抗菌和寄生虫作用，常添加进饲料中。
T15716	Lasalocid sodium 拉沙洛西钠,拉沙里菌素,Ionophore X-537A sodium,Antibiotic X-537A sodium,Lasalocid-A sodium	Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Lasalocid sodium (Lasalocid-A sodium) 是一种抗菌剂。
T11665	Ionomycin calcium SQ23377 calcium,罗红霉素钙盐(链霉菌属载体)	Apoptosis; Calcium Channel; Antibacterial; Antibiotic; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Ionomycin calcium (SQ23377 calcium) 是选择性钙离子载体，也是一种由 Streptomyces conglobatus 产生的抗生素。它对二价阳离子具有高度特异性，还诱导蛋白激酶 C 激活。Ionomycin 促进细胞凋亡。
T10662L	Calcimycin Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187	Apoptosis; Antibacterial; Antibiotic; Autophagy; Antifungal	Apoptosis; Autophagy; Microbiology/Virology
	Calcimycin (A-23187) 是抗生素和二价阳离子离子载体。它抑制革兰氏阳性细菌和一些真菌生长，也抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化。它通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。
T0906	Salinomycin 盐霉素,Procoxacin	Wnt/beta-catenin; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Salinomycin (Procoxacin)是一种多醚类钾离子载体抗生素，特异性抑制革兰氏阳性细菌生长。Salinomycin 作为Wnt/β-连环蛋白信号通路的有效抑制剂，阻断Wnt诱导的LRP6磷酸化。此外，Salinomycin (Procoxacin)对人类癌症干细胞显示出选择性活性。
TQ0215	Salinomycin sodium salt 盐霉素钠,Sodium salinomycin,Salinomycin sodium	Apoptosis; Wnt/beta-catenin; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Salinomycin sodium salt (Sodium salinomycin) 是钾离子载体抗生素，是作用于 Wnt/Fzd/LRP 复合物的Wnt/β-catenin 信号传导抑制剂，能阻断 Wnt 诱导的 LRP6 磷酸化，导致 LRP6 蛋白降解。它选择性抑制人肿瘤干细胞。
T7285	Ionomycin	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ionomycin 是一种钙离子载体和一种结合钙离子(Ca2+)的抗生素。它是由联合链霉菌(Streptomyces conglobatus)产生的。它在研究中用于提高细胞内钙水平(Ca2+)，并作为了解 Ca2+跨生物膜运输的研究工具。Ionomycin 可促进细胞凋亡，诱导蛋白激酶 C (PKC)活化。
T34611L	Semduramicin sodium UK-61,689-2,UK 61,689-2,UK 61689-2,UK-61689-2,UK61689-2
	Semduramicin sodium is a carboxylic acid ionophore for management of chicken coccidiosis.
T10662	Calcimycin hemicalcium salt Antibiotic A-23187 hemicalcium salt,A-23187 hemicalcium salt	Others	Others
	Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration.
T34611	Semduramicin UK 61,689,Aviax,UK-61,689,UK61,689
	Semduramicin is a carboxylic acid ionophore for management of chicken coccidiosis.
TN5939	Glutinone 赤杨酮,5-Glutinen-3-one
	Glutinone (IC50=24 microM) shows a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets.
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro

天然产物

Cat.No: T15717

Synonym: Lasalocid-A,Antibiotic X-537A,Ionophore X-537A

Target: Antibacterial

Lasalocid sodium

Cat.No: T15716

Synonym: 拉沙洛西钠,拉沙里菌素,Ionophore X-537A sodium,Antibiotic X-537A sodium,Lasalocid-A sodium

Target: Antibacterial, Antibiotic, Autophagy

Ionomycin calcium

Cat.No: T11665

Synonym: SQ23377 calcium,罗红霉素钙盐(链霉菌属载体)

Target: Apoptosis, Calcium Channel, Antibacterial, Antibiotic, PKC

Cat.No: T10662L

Synonym: Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187

Target: Apoptosis, Antibacterial, Antibiotic, Autophagy, Antifungal

Cat.No: T0906

Synonym: 盐霉素,Procoxacin

Target: Wnt/beta-catenin, Antibacterial

Salinomycin sodium salt

Cat.No: TQ0215

Synonym: 盐霉素钠,Sodium salinomycin,Salinomycin sodium

Target: Apoptosis, Wnt/beta-catenin, Antibacterial, Antibiotic, Autophagy

Cat.No: T7285

Target: Calcium Channel

Semduramicin sodium

Cat.No: T34611L

Synonym: UK-61,689-2,UK 61,689-2,UK 61689-2,UK-61689-2,UK61689-2

Calcimycin hemicalcium salt

Cat.No: T10662

Synonym: Antibiotic A-23187 hemicalcium salt,A-23187 hemicalcium salt

Target: Others

Cat.No: T34611

Synonym: UK 61,689,Aviax,UK-61,689,UK61,689

Cat.No: TN5939

Synonym: 赤杨酮,5-Glutinen-3-one

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

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