gravis

Sinapine 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。

Sinapine thiocyanate 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。

AChE-IN-27是一种用于高通量测定的小分子。

Pyridostigmine bromide (Mestinon) 是一种可逆的胆碱酯酶抑制剂。

Neostigmine methyl sulfate (Syntostigmin) 是一种乙酰胆碱酯酶的可逆抑制剂, 不能透过血脑屏障。

Neostigmine Bromide 是一种胆碱酯酶抑制剂，不会穿过血脑屏障，可作用于重症肌无力。

Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.

RO-1-5237 是 Pyridostigmine Bromide 的一个代谢产物，具有胆碱能特性，主要应用于重症肌无力的相关研究中。

Neostigmine Iodide is a parasympathic compound used as a reversible acetylcholinesterase inhibitor to improve muscle tone in patients with myasthenia gravis and in routine anesthesia to reverse the effects of non-depolarizing muscle relaxants such as rocu

RTC13 是一种通读试剂，可在杜氏肌营养不良症 （DMD） 的 mdx 小鼠模型中恢复抗肌萎缩蛋白表达的能力。

Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[4].

Neostigmine hydroxide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Ambenonium chloride tetrahydrate is a salt of ambenonium --- a quaternary ammonium compound with parasympathomimetic activity. It is a cholinesterase inhibitor used in the management of myasthenia gravis. Myasthenia gravis occurs when the body produces antibodies against acetylcholine receptors, and thus inhibits signal transmission across the myoneural junction. Ambenonium chloride is a rapid indirect-acting cholinergic agonist that reversibly blocks the activity of acetylcholinesterase, thereby prevents acetylcholine hydrolysis and prolonging its activity on nicotinic receptors at the neuromuscular junction.

Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Ambenonium(WIN 8077)是一种竞争性和可逆的胆碱酯酶AChE抑制剂，具有可口服的优点，IC50=0.7 nM，用于治疗重症肌无力。

Ravulizumab (ALXN1210) 是一种靶向补体因子 5 的人源化单克隆抗体，它以高亲和力特异性结合人补体蛋白 C5，可阻断补体激活。Ravulizumab 可用于预防和治疗阵发性睡眠性血红蛋白尿症、非典型溶血性尿毒症综合征和重症肌无力。

Iscalimab (CFZ-533) 是一种针对 CD40 的人源化单克隆抗体，可用于研究重症肌无力和干燥症。

Nipocalimab (M281) 是一种全人源抗 FcRn 单克隆抗体，可用于研究全身重症肌无力和类风湿性关节炎。

Distigmine Bromide is an acetylcholinesterase inhibitor. It is used for the treatment of underactive neurogenic bladder and myasthenia gravis.

AChRα(97-116) 是一种多肽，其应用于诱导实验性自身免疫性重症肌无力（EAMG）。

Pyridostigmine(Regonol) 是一种乙酰胆碱酯酶抑制剂，可通过增加突触后运动终板的乙酰胆碱来治疗重症肌无力。

Efgartigimod alfa，一种Fc受体阻滞剂，主要用于治疗重症肌无力。Efgartigimod alfa 通过降低IgG的整体水平来发挥作用，特别是针对重症肌无力中的异常乙酰胆碱受体 (AChR) 抗体。此外，Efgartigimod alfa还可与透明质酸酶进行配制使用。