gondii

13,21-Dihydroeurycomanone (Pasakbumin C) 是从 Eurycoma longifolia 根部分离得到的一种天然产物，有抗寄生虫活性。

Diclazuril (R-64433) 是一种具有口服活性的抗球虫剂，是苯乙腈衍生物。它可用于某些传染病和寄生虫病的相关研究。

Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂，是一种长效吩噻嗪抗精神病药，用于精神分裂症的研究。

CpCDPK1 TgCDPK1-IN-2 是 CpCDPK1 和 TgCDPK1 双重抑制剂，对 CpCDPK1 和 TgCDPK1 有抑制这样，IC50 值分别为 12 和 5 nM。CpCDPK1 TgCDPK1-IN-2 可用于研究弓形虫 (T. gondii)、细小隐孢子虫 (C. parvum) 和隐孢子虫 (C. hominus) 等顶复门原生动物感染相关疾病。

Spiramycin (Rovamycin) 是一种由安博链霉菌产生的大环内酯类抗生素，具有抗细菌和弓形虫活性，并具有抗寄生虫作用。它由 16 个内酯环组成，其上附着 mycaminose，forosamine 和 mycarose 三种糖。

Fanotaprim 是二氢叶酸还原酶的有效抑制剂，抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。

LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor.

Antibacterial agent 242 作为一种有效的1-去氧-D-木糖醇 5-磷酸还异构酶 (DXR) 抑制剂，针对Toxoplasmagondii显示出显著的抗性，其IC50值达到5.46 μM。此外，该化合物还能抑制体外TgDXR酶活性，并阻止T. gondii的增殖。

Conoidin A 是刚地弓形虫过氧化物酶 II 的细胞通透性抑制剂，有杀线虫特性。它共价结合 TgPrxII 的过氧化物催化位点 Cys47，不可逆地抑制其过氧化物活性，IC50为 23 µM。它也抑制哺乳动物 PrxI 和 PrxII 的氧化。它具有抗氧化、神经保护作用，可研究缺血性心脏病。

TRC-19 is a potent and selective inhibitor of Toxoplasma gondii dihydrofolate reductase. TRC-19 shows an IC50 of 9 nM and 89-fold selectivity in favor of Toxoplasma gondii dihydrofolate reductase.

Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Antiprotozoal antibiotics. II. Isolation and characterization of trypacidin, a new antibiotic, active against Trypanosoma cruzi and Toxoplasma gondiiJ. Antibiot. (Tokyo)16157-160(1963) 2.Song, Z., Liu, Y., Gao, J., et al.Antitubercular metabolites from the marine-derived fungus strain Aspergillus fumigatus MF029Nat. Prod. Res.1-8(2019) 3.Gauthier, T., Wang, X., Dos Santos, J.S., et al.Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cellsPLoS One7(2)e29906(2012)

MC1742 是一种广谱的 HDAC 抑制剂，抑制 HDAC1、HDAC2、HDAC3、HDAC6、HDAC8、HDAC10 和 HDAC11。MC1742 在体外抑制寄生虫的生长，可阻断刚地弓形虫速殖子的生长并严重破坏寄生虫基因表达。MC1742 具有潜在的抗癌活性，抑制癌细胞生长停滞、凋亡和分化。

Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2]. Purfalcamine has low activity against Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3)[1]. Purfalcamine (225, 450 nM) has no effect on the parasitemia in the first 32 hours. After about 40 hours, parasite level remains stable and then begins dropping[1]. Purfalcamine inhibits proliferation with EC50s of 171-259 nM for P. falciparum strains (3D7, Dd2, FCB, HB3 and W2), which indicates effectiveness against drug-resistant parasites[1]. Given that the EC50 value for P. falciparum (3D7) is 230 nM, Purfalcamine shows a therapeutic window ranging from 23-fold to 36-fold (EC50s for CHO=12.33 μM, HEp2=7.235 μM, HeLa=7.029 μM and Huh7=5.476 μM)[1]. Purfalcamine (10 mg kg; oral gavage; BID; for 6 days) demonstrates a delay in the onset of parasitemia in treated mice[1]. Purfalcamine (20 mg kg; orally gavage) exhibits a Cmax of 2.6 μM with a half-life of 3.1 hours[1]. Animal Model: Male BALB c mice, 7 weeks of age with the malaria parasite[1] [1]. Nobutaka Kato, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol. 2008 Jun;4(6):347-56. [2]. Rajshekhar Y Gaji, et al. Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother. 2014 May;58(5):2598-607.

17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection.

Anti-Trypanosoma cruzi agent-1 (Compd 3b) 对NINOA trypomastigote (IC50= 0.51 μM) 和 INC-5 epimastigote (IC50= 3.06 μM) 锥虫具有选择性，具有有效的抗弓形虫活性。

MMV687807 is a potent anthelmintic compound exhibiting strong efficacy against Toxoplasma gondii (T. gondii). It demonstrates an IC50 value of 0.15 μM and a CC50 value of 1.69 μM [1].

GW300657X is a small molecule inhibitor that blocks toxoplasma gondii rhoptry kinase 18 and maintains moderate CDK2-cyclin A inhibitory activity.

Phosphoglucomutase可促进弓形虫的囊肿发育。缺乏 Phosphoglucomutase 会引发代谢疾病。

4-(3,4-Difluorobenzo)curcumin（CDF）是一种具有抗寄生虫和抗癌活性的半合成香豆素。它能减少被T. gondii持鞭毛体和无鞭毛体感染的Vero细胞的数量（EC50s分别为0.8和0.37 µM）。CDF（4和8 µM）通过增强5-氟尿嘧啶和奥沙利铂对化药抵抗性HCT116细胞主要和次要结肠球形成的抑制作用。

4-Thiouracil is a photoactivatable probe designated for site-specific applications in detecting RNA structures and nucleic acid-nucleic acid contacts. Upon illumination with ultraviolet light exceeding 300 nm and in the presence of oxygen, it serves as an energy donor, facilitating the generation of singlet oxygen through triplet-triplet energy transfer. This process enables the highly reactive oxygen species to interact with 4-thiouracil, leading to the formation of uracil and uracil-6-sulfonate; the latter exhibits fluorescence around a wavelength of approximately 390 nm. Additionally, 4-Thiouracil functions as a substrate for T. gondii uracil phosphoribosyltransferase, allowing the synthesis of 4-thiouridine monophosphate for subsequent integration into RNA.

TgENR-IN-1 (Compound 5a) 作为弓形虫烯酰还原酶 (TgENR) 抑制剂, 在1 μM 浓度时可降低25%的TgENR活性。其在寄生虫组织中显示出的毒性较高，IC50 值超过 10 μM。