f1

F-1 是 ALK 和 ROS1 的双重抑制剂，抑制 ALK 的磷酸化及下游通路，可作用于对 ALKWT (IC50:2.1 nM)，ROS1WT (IC50:2.3 nM)，ALKL1196M (IC50:1.3 nM) 和 ALKG1202R (IC50:3.9 nM)。

Coreanoside F1 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126048，CAS号为 132282-69-0。

Ginsenoside F1 (20(S)-Ginsenoside F1) 是一种 Ginsenoside Rg1 的酶促修饰衍生物，它竞争性抑制CYP3A4，对 CYP2D6 具有较弱的抑制作用。

Marstenacisside F1（化合物1）为从通关藤(Marsdenia tenacissima)分离的抗炎聚氧孕烷苷，能抑制脂多糖激活的RAW 264.7细胞产生一氧化氮(NO)，属Tenacigenin B衍生物。

F1是一种抗炎肽，由HIV-1 Tat蛋白质转导域与对应于抑制因子NF-κB激酶-相互作用肽（IKIP）46-60残基的15氨基酸肽链接而成。在5 µM浓度下，F1抑制了小鼠腹腔巨噬细胞中LPS诱导的IκB激酶α（IKKα）和IKKβ的磷酸化以及NF-κB（p65）的核内转移。在体内，F1（5 mg/kg）降低了LPS诱导的脓毒症小鼠模型中IL-6、TNF-α和IL-1β的血清水平，并增加了生存率。

Momordicoside F1 may have antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines.

Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.

Goshonoside F1是半糯米品种水稻的脂质代谢产物，可被当作培育优良水稻的一个指标。

Schidigerasaponin F1 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125155，CAS号为 266998-42-9。

GSK-F1 (PI4KA inhibitor-F1) 是一种新型强效 PI4KA 抑制剂。

F1-RIBOTAC 是一种核糖核酸酶靶向嵌合体 (RIBOTAC)，通过 RNase L 依赖的机制抑制 QSOX1-amRNA 的表达。F1-RIBOTAC 可用于癌症研究。（Pink: RNA ligand; Black: linker; Blue: RNase L ligand）

(3S)-GSK-F1是一种选择性PI4KIIIα抑制剂，pIC50=8.3。

Kaji-ichigoside F1 shows antiinflammatory antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibite

3-Acetyl-ginsenoside F1 可用于生命科学领域的相关研究，其产品编号为 TN6448。

13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach. The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α.

8-iso Prostaglandin F1α（8-异前列腺素 F1α）是一种由花生四烯酸产生的异前列腺素，能引起浓度依赖性的的血管收缩效应，包括肺动脉（PA）、肺静脉（PV）和肠系膜动脉（MA），通过TXA2R、酪氨酸激酶和Rho激酶的激活。

8-iso Prostaglandin F1β（8-异前列腺素 F1β）是一种由花生四烯酸产生的异前列腺素，能引起浓度依赖性的的血管收缩效应，包括肺动脉（PA）、肺静脉（PV）和肠系膜动脉（MA），通过TXA2R、酪氨酸激酶和Rho激酶的激活。

6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.

11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs.

11-deoxy PGF1β is a synthetic analog of PGF1β. In contrast to PGF2α and PGF1α, 11-deoxy PGF1β exhibits vasodepressor and bronchodilator activities in guinea pigs at a dose of 500 μg kg.

Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3]

15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.

2,3-dinor-8-iso Prostaglandin F1α（2,3-dinor-8-iso PGF1α）是一种异前列腺素和花生四烯酸的活性代谢物，也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩（EC50s分别为12.8和18.5 nM），但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时，它能增加孤立的猪大脑切片中的血栓素B2（TXB2）水平，这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体（nAChR）拮抗剂α-conotoxin来逆转。

Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α), a cyclooxygenase (COX) metabolite produced from eicosapentaenoic acid (EPA) in a variety of tissues including seminal vesicles, lungs, polymorphonuclear leukocytes, and ocular tissues, alongside other 3-series COX products from EPA such as PGF3α, PGE3, and thromboxane B3, is potentially linked to a lower occurrence of glaucoma in individuals consuming a marine-rich (EPA-rich) diet.