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TargetMol产品目录中 "

epothilone a

"的结果
  • 抑制剂&激动剂
    11
    TargetMol | Inhibitors_Agonists
  • 化合物库
    1
    TargetMol | Compound_Libraries
  • 天然产物
    4
    TargetMol | Natural_Products
  • Epothilone A
    埃博霉素 A, epothile, Epo A
    T6490152044-53-6
    Epothilone A (Epo A) 是紫杉醇和管蛋白聚合物结合的一种竞争性抑制剂,其Ki 值为 0.6-1.4 μM。
    • ¥ 223
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Epothilone F
    T31657208518-52-9
    Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F prevents cancer cells from dividing
    • 待询
    规格
    数量
  • Epothilone E
    埃博霉素E
    T72934201049-37-8
    Epothilone E,作为Epothilone的衍生化合物,通过抑制微管蛋白功能来阻碍细胞分裂,从而展现出抗肿瘤活性。
    • ¥ 23800
    10-14周
    规格
    数量
  • Epothilone D1
    T82453252917-35-4
    Epothilone D1为分离得到的天然产物,展现对小鼠成纤维细胞的细胞毒性。
    • 待询
    规格
    数量
  • Epothilone B
    帕妥匹隆, Patupilone, EPO 906
    T6075152044-54-7
    Epothilone B (EPO 906) 是微管稳定剂,Ki 为0.71 μM。 它与αβ-微管蛋白异二聚体亚基结合,使αβ-微管蛋白解离减少。
    • ¥ 289
    In stock
    规格
    数量
  • Epofolate
    T68232958646-17-8
    Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and stabilizes microtubules against depolymerization, resulting in the inhibition of mitosis and cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
    • 待询
    6-8周
    规格
    数量
  • Iso-Fludelone
    T68860691868-19-6
    Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2 M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as well as reduced toxicity. In addition, this agent is a not a substrate of the P-glycoprotein (P-gp), a multidrug resistance pump often overexpressed in cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
    • ¥ 10600
    6-8周
    规格
    数量
  • Sagopilone
    T69480305841-29-6
    Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2 M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum.
    • ¥ 30400
    10-14周
    规格
    数量
  • KOS-1584
    T715771032119-44-0
    KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2 M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump.
    • ¥ 28200
    10-14周
    规格
    数量
  • Epothilone C
    埃博霉素 C
    TN8938186692-73-9
    Epothilone C 是一种聚酮类天然产物,由多酶系统中的一个非核糖体肽合成酶 (NRPS) 和九个多酮合成酶 (PKS) 分子共同合成。Epothilone C 可用于肿瘤研究。
    • 待询
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  • Epothilone D
    KOS 862, 埃博霉素
    TQ0202189453-10-9
    Epothilone D (KOS 862) is an effective microtubule stabilizer.
    • ¥ 7000
    5日内发货
    规格
    数量
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