aldh 3

ALDH3A1-IN-2 (Compound 19) 作为一种高效的ALDH3A1抑制剂，其IC50值达到1.29 μM。由于醛脱氢酶 (ALDH) 在前列腺癌等多种肿瘤类型中的过表达，ALDH3A1-IN-2 显示出其在癌症疾病研究中的应用潜力。

ALDH3A1-IN-1 是一种小分子 ALDH3A1 抑制剂，（IC50:1.61 μM)，可用于研究高脯氨酸血症和干燥-拉森综合征。

ALDH1A3-IN-1 (Compound 14) 是有效的 ALDH1A3抑制剂，可用于前列腺癌的研究， (IC50 = 0.63 μM; Ki = 0.46 μM)。

ALDH1A3-IN-2 是一种有效的 ALDH1A3 抑制剂，IC50 为 0.30 μM。ALDH1A3-IN-2 具有癌症疾病研究的潜力。

NR6是一种新型、高效且高度选择性的ALDH1A3抑制剂。它能有效抑制间皮瘤多细胞球生长和中性粒细胞的招募。

ALDH1A1-IN-3 是一种良好的、选择性的醛脱氢酶 1A1 (ALDH1A1) 抑制剂 (IC50: μM)。ALDH1A1-IN-3 可以有效的改善 HepG2 细胞的葡萄糖消耗。ALDH1A1-IN-3 能够用于进行改善糖代谢的研究。

CB29 是醛脱氢酶 3A1 (ALDH3A1) 的特异性抑制剂。

Metapramine (19560 RP) 是一种新型精神兴奋剂，是N-甲基-D-天冬氨酸受体(NMDA)拮抗剂，具有抗抑郁和抗伤害感受活性，可促进纹状体中的乙酰胆碱水平增加。

Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分，具有显著的杀菌和杀真菌作用。

3-Hydroxybenzaldehyde 是很多酚类化合物的前体分子。它是人和大鼠醛脱氢酶 (ALDH) 的底物 (substrate)。它具有血管保护的作用。

CVT-10216 是可逆的、选择性的醛脱氢酶 2（ALDH-2）抑制剂，IC50为 29 nM。对 ALDH-1的抑制作用较弱，IC50为 1.3 μM。 它可以减少偏爱酒精的大鼠过量饮酒，并表现出抗焦虑作用。

BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the efflux pump P-glycoprotein (P-gp) but co-application of BAAA with a P-gp inhibitor, such as verapamil , inhibits BAA efflux.2BAAA-DA has been used to isolate human hematopoietic progenitor cells, which have high ALDH activity, andviaflow cytometry to sort cancer stem cells that contain high levels of ALDH.1,3BAA used in cells can be excited at 488 nm and displays an emission maximum of 512 nm.4 1.Storms, R.W., Trujillo, A.P., Springer, J.B., et al.Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activityProceedings of the National Academy of Sciences of the United States of America96(16)9118-9123(1999) 2.Smith, C.A., Colvin, M., Storms, R.W., et al.BODIPY aminoacetaldehyde diethyl acetal08010501.81-15(2010) 3.Leng, Z., Yang, Z., Li, L., et al.A reliable method for the sorting and identification of ALDHhigh cancer stem cells by flow cytometryExp. Ther. Med.(2017) 4.Pomper, M.G., Wang, H., Minn, I., et al.Red fluorescent aldehyde dehydrogenase (ALDH) substrate(2015)

DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.[4]