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Anti-ALDH3A1 Antibody (2Z529)
还可以产品编号 TMAY-02376
Anti-ALDH3A1 Antibody (2Z529) 是一种 Rabbit 抗体，靶向 ALDH3A1。Anti-ALDH3A1 Antibody (2Z529) 可用于 WB,ELISA。
Anti-ALDH3A1 Antibody (2Z529)
Anti-ALDH3A1 Antibody (2Z529)
还可以产品编号 TMAY-02376
Anti-ALDH3A1 Antibody (2Z529) 是一种 Rabbit 抗体，靶向 ALDH3A1。Anti-ALDH3A1 Antibody (2Z529) 可用于 WB,ELISA。
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抗原信息
| 产品描述 | Anti-ALDH3A1 Antibody (2Z529) is a Rabbit antibody targeting ALDH3A1. Anti-ALDH3A1 Antibody (2Z529) can be used in WB,ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 2Z529 |
| 交叉反应 | Human |
| 验证活性 | Anti-ALDH3A1 rabbit monoclonal antibody at 1:500 dilution. -Lane A: A549 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:50 kDa. -Observed band size:50 kDa |
| 应用 | WB,ELISA |
| 推荐剂量 | WB: 1:500-1:2000; ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human ALDH3A1 (rh ALDH3A1; TMPY-02299; AAH04370.1; Met1-His453). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resistance to cellular oxidative stress. Aldehyde dehydrogenase 1A1 (ALDH1A1) and ALDH3A1 are corneal crystallins. They protect inner ocular tissues from ultraviolet radiation (UVR)-induced oxidative damage through catalytic and non-catalytic mechanisms. Additionally, ALDH3A1 has been postulated to play a regulatory role in the corneal epithelium based on several studies that report an inverse association between ALDH3A1 expression and corneal cell proliferation. Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in many cellular oxidative processes, including cancer chemoresistance, by metabolizing activated forms of oxazaphosphorine drugs such as cyclophosphamide (CP) and its analogues, such as mafosfamide (MF), ifosfamide (IFM), and 4-hydroperoxycyclophosphamide (4-HPCP). Compounds that can selectively target ALDH3A1 could permit delineation of its roles in these processes and could restore chemosensitivity in cancer cells that express this isoenzyme. ALDH3A1 may act to protect corneal cells against cellular oxidative damage by metabolizing toxic lipid peroxidation products (e.g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human ALDH3A1 Protein (TMPY-02299) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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