Pimaric acid

Pimaric acid 是一种天然树脂酸，可在 Aralia cordata 及多种松属植物中发现。Pimaric acid 通过诱导内质网应激、激活半胱天冬酶依赖性凋亡、细胞周期阻滞及抑制卵巢癌细胞迁移发挥抗癌作用。此外，Pimaric acid 可抑制 TNF-α 刺激的人主动脉平滑肌细胞 (HASMCs) 中基质金属蛋白酶-9 (MMP-9) 的 mRNA 表达、蛋白水平及启动子活性，支持其在癌症及血管研究中的应用价值。

Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interacti